Abstracts
This literature review discusses the most frequently used serodiagnostic methods for the determination of the humoral immune response to malarial parasites. The importance of malaria as a global public health problem is stressed in the light of the new discoveries leading to the future development of an anti-malarial vaccine suitable for use in humans. Serological techniques are expected to play an important role in the assessment of the relative efficacy of these candidate vaccines. A discussion of the different antigen preparation techniques is also presented.
Malaria; Serodiagnostic methods; Humoral immune response; Antigen preparation techniques
Neste trabalho são revistos os métodos sorodiagnósticos mais frequentemente utilizados para a determinação da resposta imune humoral aos parasitas da malária. A importância desta doença como um problema mundial de saúde pública é enfatizada à luz das novas descobertas no campo imunológico que poderão culminar no desenvolvimento de uma vacina adequada para uso humano. A aplicação de técnicas sorológicas certamente será de extrema importância na avaliação da eficácia relativa destas potenciais vacinas. Discute-se também, no presente trabalho, as diferentes técnicas de preparação de antígenos.
REVIEW
Immunoserology of malaria
Imuno-sorologia da malária
Eduardo L. F. Franco
Malaria Branch. Division of Parasitic Diseases Centers of Disease Control. Atlanta, Georgia, USA
Present address Present address: Ludwig Institute for Cancer Research R. Prof. Antonio Prudente, 109 4.° andar 01509 São Paulo SP BRASIL
SUMMARY
This literature review discusses the most frequently used serodiagnostic methods for the determination of the humoral immune response to malarial parasites. The importance of malaria as a global public health problem is stressed in the light of the new discoveries leading to the future development of an anti-malarial vaccine suitable for use in humans. Serological techniques are expected to play an important role in the assessment of the relative efficacy of these candidate vaccines. A discussion of the different antigen preparation techniques is also presented.
Key words: Malaria Serodiagnostic methods Humoral immune response Antigen preparation techniques.
RESUMO
Neste trabalho são revistos os métodos sorodiagnósticos mais frequentemente utilizados para a determinação da resposta imune humoral aos parasitas da malária. A importância desta doença como um problema mundial de saúde pública é enfatizada à luz das novas descobertas no campo imunológico que poderão culminar no desenvolvimento de uma vacina adequada para uso humano. A aplicação de técnicas sorológicas certamente será de extrema importância na avaliação da eficácia relativa destas potenciais vacinas. Discute-se também, no presente trabalho, as diferentes técnicas de preparação de antígenos.
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Recebido para publicação em 18/3/1985.
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Apr 1986