Blood groups and malaria

Montoya, Fabiola; Restrepo, Marcos; Montoya, Astrid E.; Rojas, William

doi:10.1590/S0036-46651994000100006

Abstracts

The possible relationship between erythrocyte antigens and the presence of malaria infection by P. vivax and P. falciparurn was sought in four different ethnic groups of two departments of Colombia. Malaria infection by P. falciparum was found in 91.4% of malaria infected blacks. No significant differences were found between the presence of malaria infection and ABO antigens. In the other blood groups, it was observed that groups MNSs conferred black people a greater Rr for malaria by both species of Plasmodium and that Duffy-negative blacks and indians appeared to be resistant to P. vivax infection. A predominance of P. vivax infection was observed in Katio indians while P.falciparum was predominant in Kuna indians; the reason for this finding still needs to be explored.

Malaria; Plasmodium; Blood groups

Con el presente estudio se evalúa la relación existente entre la infección por P. vivax y P. falciparum y los antígenos eritrocitos de cuatro diferentes grupos étnicos en Colombia. P. falciparum se encontró causando malaria en el 91.4% de los individuos de raza negra que tuvieron malaria. No hubo diferenciais significativas entre la infección malaria y los antígenos ABO. La presencia de grupos del sistema MNSs en persona de raza negra confiere un mayor riesgo relativo por la infección para las dos especies de Plasmodium, igualmente hay mayor riesgo cuando se pertenece a la raza negra o indígena y el grupo Duffy es negativo. La infección por P. vivax predomina en los indios Katios pero en los Kunas prevalece P. falciparum.

PARASITOLOGY

Blood groups and malaria

Grupos sanguíneos y malaria

Fabiola Montoya; Marcos Restrepo; Astrid E. Montoya; William Rojas

Corporación para investigaciones Biológicas C. I. B. Medellin A. A. 73-78

^{Address for correspondence} Address for correspondence: Fabíola Montoya R. Corporación para Investigaciones Biológicas C. I. B. Medellin A. A. 73-78, Colombia

SUMMARY

The possible relationship between erythrocyte antigens and the presence of malaria infection by P. vivax and P. falciparurn was sought in four different ethnic groups of two departments of Colombia.

Malaria infection by P. falciparum was found in 91.4% of malaria infected blacks. No significant differences were found between the presence of malaria infection and ABO antigens. In the other blood groups, it was observed that groups MNSs conferred black people a greater Rr for malaria by both species of Plasmodium and that Duffy-negative blacks and indians appeared to be resistant to P. vivax infection. A predominance of P. vivax infection was observed in Katio indians while P.falciparum was predominant in Kuna indians; the reason for this finding still needs to be explored.

Keywords: Malaria; Plasmodium; Blood groups.

RESUMEN

Con el presente estudio se evalúa la relación existente entre la infección por P. vivax y P. falciparum y los antígenos eritrocitos de cuatro diferentes grupos étnicos en Colombia.

P. falciparum se encontró causando malaria en el 91.4% de los individuos de raza negra que tuvieron malaria. No hubo diferenciais significativas entre la infección malaria y los antígenos ABO. La presencia de grupos del sistema MNSs en persona de raza negra confiere un mayor riesgo relativo por la infección para las dos especies de Plasmodium, igualmente hay mayor riesgo cuando se pertenece a la raza negra o indígena y el grupo Duffy es negativo. La infección por P. vivax predomina en los indios Katios pero en los Kunas prevalece P. falciparum.

Full text available only in PDF format.

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Recebido para publicação em 07/10/1992.

Aceito para publicação em 26/11/1993.

1. ALKAWA, M.; MILLER, L.H.; JOHNSON, J. & RABBAGE, J. - Erythrocyte entry by malarial parasites. A moving junction between erythrocyte and parasite. J. Cell Biol., 77: 72-82, 1978.
2. ALLISON, A.C. - Protection afforded by sickle-cell trait against subtertian malarial infection. Brit. med. J., 1: 290-294, 1954.
3. ANTHONY, H.M. - Blood groups and the response to immunotherapy. Cancer Immunol. Immunother, 2: 287, 1981.
4. AHA, M.M. & EI-GAMAL, R.L.R. - ABO blood groups. Indian Pediat., 22: 857-858, 1985.
5. BARNWELL, J.W.; NICHOLS, M.E. & RUBINSTEIN, P. - In vitro evaluation of the role of the Duffy blood group in erythrocyte invasion by Plasmodium vivax. J. exp. Med., 169: 1795-1802, 1989.
6. CLERKE, C.A.; McCONNELL, R.B. & SHEPPARD, P.M. - ABO blood groups and secretor character in rheumatic carditis. Brit. med. J., 1: 21-23, 1960.
7. FRIEDMAN, M.J. - Erythrocyte mechanism of sickle-cell resistance to malaria. Proc. nat. Acad. Sci. (Wash.), 75: 1994-1997, 1978.
8. GUPTA, M. & RAI CHOWDHURI, A.N. - Relationship between ABO blood groups and malaria. Bull. Wld. H1th. Org., 55: 157-162, 1977.
9. KNIGHT, R.H. & ROBERTSON, D.H.H. - The prevalence of the erythrocyte glucose-6-phosphate dehydrogenase deficiency among Africans in Uganda. Trans. roy.Soc. trop. Med. Hyg., 57: 95-100, 1963.
10. LEES, R.S. & LEES, A.M. - Effect of ABO blood group antigens on long-term survival after cardiac transplantation. New Engl. J. Med., 307: 1274, 1982.
11. LENKA, M.R.; GHOSH, E. & BHATTACHARYVA, P.K. - ABO blood groups in relation to hepatitis B surface antigen (Australia antigen). Trans. roy. Soc. trop. Med. Hyg., 75: 688-690, 1981.
12. LOMBERG, H.; HANSON L.A.; JACOBSON, B. et al. Correlation of B blood group, vesicoureteral reflux and bacterial attachment in patients with recurrent pyelonephritis. New Engl. J. Med., 308: 1189, 1983.
13. MARTIN, S.K.; MILLER, L.H.; ALLING, D. et al. - Severe malaria and glucose-6-phosphate dehydrogenase deficiency: a reappraisal of the malaria G-6-P.D. hypothesis. Lancet, 1: 524-526, 1979.
14. MATHEWS, H.M. & ARMSTRONG, J.C. - Duffy blood types and vivax malaria in Ethiopia. Amer. J. trop. Med. Hyg., 27: 1069-1072, 1978.
15. McDONALD, J.C. & ZUCKERMAN, A.J. - ABO blood groups and acute respiratory virus disease. Brit. med. J., 2: 89-90, 1962.
16. MILLER, L.H.; MASON, S.J.; CLYDE, D.F. & McGINNISS, M.H. - The resistance factor to P. vivax in blacks. The Duffy blood group genotype, Fy Fy. New Engl. J. Med., 295: 302-304, 1976.
17. MILLER, L.H.; McAULIFFE, F.M. & MASON, S.J. - Erythrocyte receptors for malaria merozoites. Amer. J. trop. Med. Hyg., 26: 204-208, 1977.
18. PASVOL, G. & WILSON, R.J.M. - The interaction of malaria parasites with red blood cells. Brit. med. Bull., 38: 133-140, 1982.
19. RAY, R.N.; CHATTERJEE, J.B. & CHOWDHURI, A.N.R. - Observations on the resistance of Hb - E thalassemia disease to infection of Plasmodium vivax. WHO/MAL/395, 1963.
20. RESTREPO, A.; PALACIO, S. & FORERO, J.M. - Frecuencia de los grupos sanguíneos ABO y Rh en población mixta de la ciudad de Medellin (Ant.) y en negros de la ciudad de Quibdo (Choco) y revisión de la literatura colombiana, Antióquia méd., 14: 68-79, 1964.
21. SPENCER, H.C.; MILLER, L.H.; COLLINS, W.E. et al. - The Duffy blood group and resistance to Plasmodium vivax in Honduras. Amer. J. trop. Med. Hyg., 27: 664-670, 1978.
22. SVEJGAARD, A.; JERSILD, I.; STAUB NIELSEN, L. & BODMER, W.F. - HLA antigens and disease. Statistical and genetical considerations. Tissue Antigens., 4: 95-105, 1974.
23. WELCH, S.G.; McGREGOR, I.A. & WILLIAMS, K. - The Duffy blood group and malaria prevalence in Gambian West Africans. Trans. roy. Soc. trop. Med. Hyg., 71: 295-296, 1977.
24. WERTHEIMER, S.P. & BARNWELL, J.W. - Plasmodium vivax interaction with the human Duffy blood group glycoprotein: identification of a parasite receptor- like protein. Exp. Parasit., 69: 340-350, 1989.
25. WOOLF, B. - On estimating the relation between blood group and disease. Ann. hum. genet., 19: 251-253, 1955.
26. YOUNG, M.D.; EYLES, D.E.; BURGESS, R.W. & JEFFERY, G.M. - Experimental testing of Negroes to Plasmodium vivax. J. Parasit., 41: 315-318, 1955.

Address for correspondence:

Fabíola Montoya R.

Corporación para Investigaciones Biológicas C. I. B.

Medellin A. A. 73-78, Colombia

Publication Dates

Publication in this collection
20 Sept 2006
Date of issue
Feb 1994

History

Received
07 Oct 1992
Accepted
26 Nov 1993

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. ALKAWA, M.; MILLER, L.H.; JOHNSON, J. & RABBAGE, J. - Erythrocyte entry by malarial parasites. A moving junction between erythrocyte and parasite. J. Cell Biol., 77: 72-82, 1978.

[2] 2. ALLISON, A.C. - Protection afforded by sickle-cell trait against subtertian malarial infection. Brit. med. J., 1: 290-294, 1954.

[3] 3. ANTHONY, H.M. - Blood groups and the response to immunotherapy. Cancer Immunol. Immunother, 2: 287, 1981.

[4] 4. AHA, M.M. & EI-GAMAL, R.L.R. - ABO blood groups. Indian Pediat., 22: 857-858, 1985.

[5] 5. BARNWELL, J.W.; NICHOLS, M.E. & RUBINSTEIN, P. - In vitro evaluation of the role of the Duffy blood group in erythrocyte invasion by Plasmodium vivax. J. exp. Med., 169: 1795-1802, 1989.

[6] 6. CLERKE, C.A.; McCONNELL, R.B. & SHEPPARD, P.M. - ABO blood groups and secretor character in rheumatic carditis. Brit. med. J., 1: 21-23, 1960.

[7] 7. FRIEDMAN, M.J. - Erythrocyte mechanism of sickle-cell resistance to malaria. Proc. nat. Acad. Sci. (Wash.), 75: 1994-1997, 1978.

[8] 8. GUPTA, M. & RAI CHOWDHURI, A.N. - Relationship between ABO blood groups and malaria. Bull. Wld. H1th. Org., 55: 157-162, 1977.

[9] 9. KNIGHT, R.H. & ROBERTSON, D.H.H. - The prevalence of the erythrocyte glucose-6-phosphate dehydrogenase deficiency among Africans in Uganda. Trans. roy.Soc. trop. Med. Hyg., 57: 95-100, 1963.

[10] 10. LEES, R.S. & LEES, A.M. - Effect of ABO blood group antigens on long-term survival after cardiac transplantation. New Engl. J. Med., 307: 1274, 1982.

[11] 11. LENKA, M.R.; GHOSH, E. & BHATTACHARYVA, P.K. - ABO blood groups in relation to hepatitis B surface antigen (Australia antigen). Trans. roy. Soc. trop. Med. Hyg., 75: 688-690, 1981.

[12] 12. LOMBERG, H.; HANSON L.A.; JACOBSON, B. et al. Correlation of B blood group, vesicoureteral reflux and bacterial attachment in patients with recurrent pyelonephritis. New Engl. J. Med., 308: 1189, 1983.

[13] 13. MARTIN, S.K.; MILLER, L.H.; ALLING, D. et al. - Severe malaria and glucose-6-phosphate dehydrogenase deficiency: a reappraisal of the malaria G-6-P.D. hypothesis. Lancet, 1: 524-526, 1979.

[14] 14. MATHEWS, H.M. & ARMSTRONG, J.C. - Duffy blood types and vivax malaria in Ethiopia. Amer. J. trop. Med. Hyg., 27: 1069-1072, 1978.

[15] 15. McDONALD, J.C. & ZUCKERMAN, A.J. - ABO blood groups and acute respiratory virus disease. Brit. med. J., 2: 89-90, 1962.

[16] 16. MILLER, L.H.; MASON, S.J.; CLYDE, D.F. & McGINNISS, M.H. - The resistance factor to P. vivax in blacks. The Duffy blood group genotype, Fy Fy. New Engl. J. Med., 295: 302-304, 1976.

[17] 17. MILLER, L.H.; McAULIFFE, F.M. & MASON, S.J. - Erythrocyte receptors for malaria merozoites. Amer. J. trop. Med. Hyg., 26: 204-208, 1977.

[18] 18. PASVOL, G. & WILSON, R.J.M. - The interaction of malaria parasites with red blood cells. Brit. med. Bull., 38: 133-140, 1982.

[19] 19. RAY, R.N.; CHATTERJEE, J.B. & CHOWDHURI, A.N.R. - Observations on the resistance of Hb - E thalassemia disease to infection of Plasmodium vivax. WHO/MAL/395, 1963.

[20] 20. RESTREPO, A.; PALACIO, S. & FORERO, J.M. - Frecuencia de los grupos sanguíneos ABO y Rh en población mixta de la ciudad de Medellin (Ant.) y en negros de la ciudad de Quibdo (Choco) y revisión de la literatura colombiana, Antióquia méd., 14: 68-79, 1964.

[21] 21. SPENCER, H.C.; MILLER, L.H.; COLLINS, W.E. et al. - The Duffy blood group and resistance to Plasmodium vivax in Honduras. Amer. J. trop. Med. Hyg., 27: 664-670, 1978.

[22] 22. SVEJGAARD, A.; JERSILD, I.; STAUB NIELSEN, L. & BODMER, W.F. - HLA antigens and disease. Statistical and genetical considerations. Tissue Antigens., 4: 95-105, 1974.

[23] 23. WELCH, S.G.; McGREGOR, I.A. & WILLIAMS, K. - The Duffy blood group and malaria prevalence in Gambian West Africans. Trans. roy. Soc. trop. Med. Hyg., 71: 295-296, 1977.

[24] 24. WERTHEIMER, S.P. & BARNWELL, J.W. - Plasmodium vivax interaction with the human Duffy blood group glycoprotein: identification of a parasite receptor- like protein. Exp. Parasit., 69: 340-350, 1989.

[25] 25. WOOLF, B. - On estimating the relation between blood group and disease. Ann. hum. genet., 19: 251-253, 1955.

[26] 26. YOUNG, M.D.; EYLES, D.E.; BURGESS, R.W. & JEFFERY, G.M. - Experimental testing of Negroes to Plasmodium vivax. J. Parasit., 41: 315-318, 1955.

Brasil

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Blood groups and malaria

Grupos sanguíneos y malaria

Abstracts

Address for correspondence:

Publication Dates

History