The effect of a dialyzable transfer factor (TFd) in the experimental american trypanosomiasis of mice: preliminary report

Menezes, Humberto

doi:10.1590/S0037-86821977000400001

Abstracts

A dialyzable transfer factor (TFd) was obtained from spleen cells, of mice vaccinated with the avirulent PF strain of Trypanosoma cruzi. This factor reduced significahtly the parasitemia of animals treated before or after the infection with a virulent strain of the same parasite, but does not reduced the mortality rate to a level lower than that of the control mice. It is expected that in a next future, new techniques in the use ofsuch factor will bring better resutts.

Um fator dialisavel capaz de transferir a imunidade de células sensibilizadas foi obtido de camundongos vacinados com a cepa PF. Este fator foi capaz de reduzir significantemente a parasitemia de animais previamente tratados com o mesmo e depois infectados ou de camundongos infectados inicialmente e depois tratados. Os resultados foram considerados pobres com respeito a mortalidade dos tratados, mas não dcsencorajadores, esperando-se melhores conclusões no futuro.

The effect of a dialyzable transfer factor (TFd) in the experimental american trypanosomiasis of mice.^* * Presented partially to the 6 a Cong. Latinoemericano de Farmacologia. 04/12/1976. Buenos Aires. Argentina. (Preliminary report)

Humberto Menezes ^** ** Depart. Genética. FMRP. USP. 14.100. Ribeirão Preto. S.P. - Brasil.

ABSTRACT

A dialyzable transfer factor (TFd) was obtained from spleen cells, of mice vaccinated with the avirulent PF strain of Trypanosoma cruzi.

This factor reduced significahtly the parasitemia of animals treated before or after the infection with a virulent strain of the same parasite, but does not reduced the mortality rate to a level lower than that of the control mice.

It is expected that in a next future, new techniques in the use ofsuch factor will bring better resutts.

RESUMO

Um fator dialisavel capaz de transferir a imunidade de células sensibilizadas foi obtido de camundongos vacinados com a cepa PF.

Este fator foi capaz de reduzir significantemente a parasitemia de animais previamente tratados com o mesmo e depois infectados ou de camundongos infectados inicialmente e depois tratados.

Os resultados foram considerados pobres com respeito a mortalidade dos tratados, mas não dcsencorajadores, esperando-se melhores conclusões no futuro.

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

Submitted to publication on March, 1977.

1. BARRETT, J,T. - Textbook of Immunology. 1970, The C.V. Morshy Co. St. Louis.
2. BELLANTi; J.A. - Immunology. 1971. W.B, Saunders Co. Philadelphia.
3. FUDENBERG, H.H.; STITES, D.P.; CALDWELL, J.L & WELLS, J.V. - Basic and Clinical Immunology. 1976. Lange Med, Public. Los Altos. Califórnia.
4. LAWRENCE, H.S. - Transfer Factor, Advences Immunol. 11:195-1969
5. LAWRENCE, H.S. - Transfer Factor. In Mediators of Cellular Immunity. H.S. Lawrence & M. Landy. Ed. 1969. Academic Press. N. York
6. LAERENCE, H.S. - Transfer Factor. and Cellular Irnmunity. In Immunobiology. RJ. Good & D.W. Fischer. Ed. 1974. Sinauer Assoc. Inc. Publish. Sunderiand. Massachussetts.
7. MENEZES, H. - The un-inffíctivity of the PF cultivated strain of Trypanosoma cruzi to mice. evaluation through a one year period by blood cultures and histopathology. Rev. Soc. Bras. Med. Trop. 5;1-15, 1975.
8. NAKAMURA, M. - Cultivation of Trypanosoma cruzi in a Protein-free dialyzate medium. Proc. Soc. Exp. Biol. Med. 125:779-780. 1967.
9. RIBEIRO DOS SANTOS, R. - Contribuição ao estudo da imunidade na fase aguda da Doença de Chagas experimental. Tése. 1973. Fac. Ciências Med. UNICAMP. Brasil.
10. R08ERS0N, E.L. & HANSON, W.L. - Passive transfer of immunity to Trypanosoma cruzi Trans. Roy. Soc. Trop. Med. & Hyg. 68(4): 338. 1974 (Correspondence).
11. WARREN, L.G. - Metabolism of Schizotrypanum cruzi. Chagas. I-Effect of culture age and substrate concen-

*

Presented partially to the 6

^a Cong. Latinoemericano de Farmacologia. 04/12/1976. Buenos Aires. Argentina.

**

Depart. Genética. FMRP. USP. 14.100. Ribeirão Preto. S.P. - Brasil.

Publication Dates

Publication in this collection
11 June 2013
Date of issue
Aug 1977

History

Received
Mar 1977
Accepted
Mar 1977

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. BARRETT, J,T. - Textbook of Immunology. 1970, The C.V. Morshy Co. St. Louis.

[2] 2. BELLANTi; J.A. - Immunology. 1971. W.B, Saunders Co. Philadelphia.

[3] 3. FUDENBERG, H.H.; STITES, D.P.; CALDWELL, J.L & WELLS, J.V. - Basic and Clinical Immunology. 1976. Lange Med, Public. Los Altos. Califórnia.

[4] 4. LAWRENCE, H.S. - Transfer Factor, Advences Immunol. 11:195-1969

[5] 5. LAWRENCE, H.S. - Transfer Factor. In Mediators of Cellular Immunity. H.S. Lawrence & M. Landy. Ed. 1969. Academic Press. N. York

[6] 6. LAERENCE, H.S. - Transfer Factor. and Cellular Irnmunity. In Immunobiology. RJ. Good & D.W. Fischer. Ed. 1974. Sinauer Assoc. Inc. Publish. Sunderiand. Massachussetts.

[7] 7. MENEZES, H. - The un-inffíctivity of the PF cultivated strain of Trypanosoma cruzi to mice. evaluation through a one year period by blood cultures and histopathology. Rev. Soc. Bras. Med. Trop. 5;1-15, 1975.

[8] 8. NAKAMURA, M. - Cultivation of Trypanosoma cruzi in a Protein-free dialyzate medium. Proc. Soc. Exp. Biol. Med. 125:779-780. 1967.

[9] 9. RIBEIRO DOS SANTOS, R. - Contribuição ao estudo da imunidade na fase aguda da Doença de Chagas experimental. Tése. 1973. Fac. Ciências Med. UNICAMP. Brasil.

[10] 10. R08ERS0N, E.L. & HANSON, W.L. - Passive transfer of immunity to Trypanosoma cruzi Trans. Roy. Soc. Trop. Med. & Hyg. 68(4): 338. 1974 (Correspondence).

[11] 11. WARREN, L.G. - Metabolism of Schizotrypanum cruzi. Chagas. I-Effect of culture age and substrate concen-