Antibody response to Salmonella typhi lw human Schistosomiasis mansoni

Muniz-Junqueira, Maria Imaculada; Tavares-Neto, José; Prata, Aluizio; Tosta, Carlos Eduardo

doi:10.1590/S0037-86821996000500006

Abstracts

Antibody response to Salmonella typhi O and H antigens was evaluated in 24 individuals with either hepatointestinal or hepatosplenic schistosomiasis mansoni before and after typhoid vaccination, and compared with that of non-infected controls. Before vaccination, Schistosoma-infected patients showed a higher frequency of positive antibody to O antigen and the same frequency to H antigen when compared with that of healthy individuals. However, those with hepatosplenic schistosomiasis showed higher titres of antibody to H antigen than those with hepatointestinal disease or healthy individuals. Infected subjects, particularly those with hepatointestinal disease, showed a decreased response after typhoid vaccine. Tins diminished ability to mount an immune response towards typhoid antigens dining schistosomiasis may interfere ivith the clearance of the bacteria from blood stream and, therefore, play a role in the prolonged survival of salmonella as obsewed in some patients with chronic salmonellosis associated with schistosomiasis.

Schistosomiasis mansoni; Salmonella typhi; O and H antigens; Chronic salmonellosis associated with schistosomiasis

A resposta de anticorpos para os antígenos O e H da Salmonella typhi foi avaliada em 24 indivíduos com esquistossomose hepatointestinal ou hepatoesplênica antes e apôs vacinação antitifoídica, e comparada com a resposta de indivíduos controles normais. Antes da vacinação, pacientes esquistossomóticos mostraram uma maior frequência de anticoipos positivos para o antígeno O e a mesma frequência de anticoipos positivos para o antígeno H quando comparada com aquela de indivíduos controles normais. Porém, aqueles com esquistossomose hepatoesplênica mostraram títulos maiores de anticoipos para o antígeno H do que aqueles com a forma hepatointestinal da doença ou os indivíduos controles normais. Pacientes esquistossomóticos, particularmente aqueles com a forma hepatointestinal, mostraram uma menor resposta após a vacinação antitifoídica. Esta menor capacidade para apresentar uma resposta imune para antígenos de salmonela pode interferir com a retirada da bactéria da corrente sanguínea e, portanto, contribuir como um dos determinantes de sua prolongada sobrevivência como obsewada em pacientes com salmonelose septicêmica prolongada associada â esquistossomose.

Esquistosomose rnansoni; Salmonella typhi; Antígenos O e H; Salmonelose septicêmica prolongada associada à esquistossomose

ARTICLES

Antibody response to Salmonella typhi lw human Schistosomiasis mansoni

Maria Imaculada Muniz-Junqueira; José Tavares-Neto; Aluizio Prata; Carlos Eduardo Tosta

^{Adress to correspondence} Adress to correspondence: Dr a Maria Imaculada Muniz-Junqueira. Laboratório de Imunologia Celular/Depto de Patologia/FCS/UnB, 70910- 900 Brasília, DF, Brasil. Fax: (061) 233 0296

ABSTRACT

Antibody response to Salmonella typhi O and H antigens was evaluated in 24 individuals with either hepatointestinal or hepatosplenic schistosomiasis mansoni before and after typhoid vaccination, and compared with that of non-infected controls. Before vaccination, Schistosoma-infected patients showed a higher frequency of positive antibody to O antigen and the same frequency to H antigen when compared with that of healthy individuals. However, those with hepatosplenic schistosomiasis showed higher titres of antibody to H antigen than those with hepatointestinal disease or healthy individuals. Infected subjects, particularly those with hepatointestinal disease, showed a decreased response after typhoid vaccine. Tins diminished ability to mount an immune response towards typhoid antigens dining schistosomiasis may interfere ivith the clearance of the bacteria from blood stream and, therefore, play a role in the prolonged survival of salmonella as obsewed in some patients with chronic salmonellosis associated with schistosomiasis.

Keywords: Schistosomiasis mansoni. Salmonella typhi. O and H antigens. Chronic salmonellosis associated with schistosomiasis.

RESUMO

A resposta de anticorpos para os antígenos O e H da Salmonella typhi foi avaliada em 24 indivíduos com esquistossomose hepatointestinal ou hepatoesplênica antes e apôs vacinação antitifoídica, e comparada com a resposta de indivíduos controles normais. Antes da vacinação, pacientes esquistossomóticos mostraram uma maior frequência de anticoipos positivos para o antígeno O e a mesma frequência de anticoipos positivos para o antígeno H quando comparada com aquela de indivíduos controles normais. Porém, aqueles com esquistossomose hepatoesplênica mostraram títulos maiores de anticoipos para o antígeno H do que aqueles com a forma hepatointestinal da doença ou os indivíduos controles normais. Pacientes esquistossomóticos, particularmente aqueles com a forma hepatointestinal, mostraram uma menor resposta após a vacinação antitifoídica. Esta menor capacidade para apresentar uma resposta imune para antígenos de salmonela pode interferir com a retirada da bactéria da corrente sanguínea e, portanto, contribuir como um dos determinantes de sua prolongada sobrevivência como obsewada em pacientes com salmonelose septicêmica prolongada associada â esquistossomose.

Palavras-chave: Esquistosomose rnansoni. Salmonella typhi, Antígenos O e H. Salmonelose septicêmica prolongada associada à esquistossomose.

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Recebido para publicação em 05/10/95.

1. Abraham G, Teklu B, Gedebu M, Selassie GH, Azene G. Diagnostic value of the Widal test. Tropical and Geographical Medicine 33:329-333, 1981.
2. Bastos OC, Rangel HA, Magalhães LA, Piedrabuena AE. Evolução das imunoglobulinas envolvidas na resposta imune de camundongos ao Schistosoma rnansoni Revista de Saúde Pública de São Paulo 18:138-154,1984.
3. Coutinho AD, Antunes MTA, Domingues ALC. Estudo da imunidade humoral e celular da doença hepática esquistossomótica. Revista do Instituto de Medicina Tropical de São Paulo 24: 282-291,1982.
4. Editorial.Typhoid and its serology. British Medical Journal 1: 389-390,1978.
5. Gohar MA, EissaAA, Sebai I. Antibody response in Egyptian splenomegaly. The American Journal of Tropical Medicine and Hygiene 31:605-610,1951.
6. Gutteridge F. Human experimentation and medical ethics international guidelines for biomedical research involving human subjects. World Health Organization Chronicle 35:212- 215.1981.
7. Higashi GI, Young SW. Antigenic relationship of Salmonellae and schistosomes. Transactions of the Royal Society of Tropical Medicine and Hygiene 68:343,1973.
8. Katz N, Chaves A, Pellegrino J. A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni. Revista do Instituto de Medicina Tropical de São Paulo. 14:397-400,1972.
9. Lambertucci JR, Godoy P, Bambirra EA, Neves J, Tafuri WL, Leite VHR. Envolvimento renal na associação Salmonella-Schistosoma mansoni Revista da Sociedade Brasileira de Medicina Tropical 20:83-90,1987.
10. Levine MM, Grados O, Gilman RH, Woodward WE, Solis-Plaza R, Waldman W. Diagnostic value of the Widal test in areas endemic for typhoid fever. The American Journal of Tropical Medicine and Hygiene 27:795-800,1978.
11. Mackaness GB, Blanden RV, Colins FM. Host- parasite relations in mouse typhoid. Journal of Experimental Medicine 124:573-583,1966.
12. Mauel J. Effector and escape mechanisms in host parasite relationships. Progress inAllergy 31:1-75, 1982.
13. Mikhail IA, Higashi GI, Edman DC, Elwan SH. Interactions of Salmonella paratyphi A and Schistosoma mansoni in hamsters.The American Journal of Tropical Medicine and Hygiene 31:328- 334.1982.
14. Milhomen AM, Suassuna I. Investigation of the response to the enterobacterial common antigen after typhoid vaccination. Revista da Sociedade Brasileira de Medicina Tropical 20:7-12,1987.
15. Muniz-Junqueira MI, Prata A, Tosta CE. T cell- dependent immunodepression in vivo in Schistosoma mansoni infected patients. Revista da Sociedade Brasileira de Medicina Tropical 23:27-31,1990.
16. Muniz-Junqueira MI, Prata A,Tosta CE. Phagocytic and bactericidal function of mouse macrophages to Salmonella typhimurium in schistosomiasis mansoni. The American Journal of Tropical Medicine and Hygiene 46:132-136,1992.
17. Muniz-Junqueira MI, Tavares-Neto J, Ataide M, Prata A, Tosta CE. Specific treatment of hepatosplenic schistosomiasis can increase T- lymphocyte reactivity. Revista da Sociedade Brasileira de Medicina Tropical 24:97-99,1991.
18. Nash TE, Cheever AW, Ottesen EA, Cook JA. Schistosome infections in humans: perspectives and recent findings. Annals of Internal Medicine 97:740-754,1982.
19. Nash TE, Ottensen EA, Cheever AW Antibody response to a polysaccharide antigen present in the schistosome gut. II. Modulation of antibody response. The American Journal of Tropical Medicine and Hygiene 27:944-950,1978.
20. Neves J, Lobo Martins NRL. Long duration of septicaemic salmonellosis: 35 cases with 12 implicated species of Salmonella Transactions of the Royal Society of Tropical Medicine and Hygiene 61:541-552,1967.
21. Prata A. Como caracteriza a forma hepato- esplênica da esquistossomose? In: Resumos do II Simpósio sobre esquistossomose. Salvador, p. 179, 1970.
22. Rajagopalan P, Kumar R, Malaviya AN. Immunological studies in typhoid fever. I. Immunoglobulins, C3, antibodies, rheumatoid factor and circulating immune complexes in patients with typhoid fever. Clinical and Experimental Immunology 44:68-73,1981.
23. Rocha H, Kirk JW, Hearey CD. Prolonged Salmonella bacteremia in patients with Schistosoma mansoni infection. Archives of Internal Medicine 128:254-257,1971.
24. Rocha H, Magnavita M, Silva Teles E, Rebouças G. Atividade antibacteriana do soro de pacientes com forma hepatoesplênica da esquistossomose mansônica. Revista do Instituto de Medicina Tropical de São Paulo 10:364-370,1968.
25. Shikanai-Yasuda MA, Ferri RG, Yasuda PH, Fava Neto C, Silva GR, Ferreira JM. Níveis de aglutininas antitifoídicas em esquistossomóticos hepatoesplênicos. Revista de Saúde Pública de São Paulo 16:107-113,1982.
26. Shikanai-Yasuda MA,Yasuda PH, Ferri RG, Castilho EA, Shiroma M. Resposta imune humoral a vacina antitifoídica em esquistossomose mansônica hepatoesplênica. Revista do Instituto de Medicina Tropical de São Paulo 24:198-204,1982.
27. Smithers SR, Doenhoff MJ. Schistosomiasis. In: Cohen S, Warren KS (eds) Immunology of Parasitic Infections, 2nd edition, Blackwell, Oxford, p. 527-607,1982.
28. Tweardy DJ, Osman GS, El Kholy A, Ellner JJ. Failure of immunosuppressive mechanisms in human Schistosoma mansoni infection with hepatosplenomegaly. Journal of Clinical Microbiology 25:768-773,1987.
29. Welch H, Mickle FL. A rapid slide test for serological diagnosis of typhoid and paratyphoid fevers. American Journal of Public Health 26:248- 255,1936.
30. World Health Organization. Biomedical research: a revised code of ethics. World Health Organization Chronicle 30:360-362,1976. 445

Adress to correspondence:

Dr

^a Maria Imaculada Muniz-Junqueira.

Laboratório de Imunologia Celular/Depto de Patologia/FCS/UnB,

70910- 900

Brasília, DF, Brasil.

Fax: (061) 233 0296

Publication Dates

Publication in this collection
04 Apr 2013
Date of issue
Oct 1996

History

Accepted
05 Oct 1995
Received
05 Oct 1995

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Abraham G, Teklu B, Gedebu M, Selassie GH, Azene G. Diagnostic value of the Widal test. Tropical and Geographical Medicine 33:329-333, 1981.

[2] 2. Bastos OC, Rangel HA, Magalhães LA, Piedrabuena AE. Evolução das imunoglobulinas envolvidas na resposta imune de camundongos ao Schistosoma rnansoni Revista de Saúde Pública de São Paulo 18:138-154,1984.

[3] 3. Coutinho AD, Antunes MTA, Domingues ALC. Estudo da imunidade humoral e celular da doença hepática esquistossomótica. Revista do Instituto de Medicina Tropical de São Paulo 24: 282-291,1982.

[4] 4. Editorial.Typhoid and its serology. British Medical Journal 1: 389-390,1978.

[5] 5. Gohar MA, EissaAA, Sebai I. Antibody response in Egyptian splenomegaly. The American Journal of Tropical Medicine and Hygiene 31:605-610,1951.

[6] 6. Gutteridge F. Human experimentation and medical ethics international guidelines for biomedical research involving human subjects. World Health Organization Chronicle 35:212- 215.1981.

[7] 7. Higashi GI, Young SW. Antigenic relationship of Salmonellae and schistosomes. Transactions of the Royal Society of Tropical Medicine and Hygiene 68:343,1973.

[8] 8. Katz N, Chaves A, Pellegrino J. A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni. Revista do Instituto de Medicina Tropical de São Paulo. 14:397-400,1972.

[9] 9. Lambertucci JR, Godoy P, Bambirra EA, Neves J, Tafuri WL, Leite VHR. Envolvimento renal na associação Salmonella-Schistosoma mansoni Revista da Sociedade Brasileira de Medicina Tropical 20:83-90,1987.

[10] 10. Levine MM, Grados O, Gilman RH, Woodward WE, Solis-Plaza R, Waldman W. Diagnostic value of the Widal test in areas endemic for typhoid fever. The American Journal of Tropical Medicine and Hygiene 27:795-800,1978.

[11] 11. Mackaness GB, Blanden RV, Colins FM. Host- parasite relations in mouse typhoid. Journal of Experimental Medicine 124:573-583,1966.

[12] 12. Mauel J. Effector and escape mechanisms in host parasite relationships. Progress inAllergy 31:1-75, 1982.

[13] 13. Mikhail IA, Higashi GI, Edman DC, Elwan SH. Interactions of Salmonella paratyphi A and Schistosoma mansoni in hamsters.The American Journal of Tropical Medicine and Hygiene 31:328- 334.1982.

[14] 14. Milhomen AM, Suassuna I. Investigation of the response to the enterobacterial common antigen after typhoid vaccination. Revista da Sociedade Brasileira de Medicina Tropical 20:7-12,1987.

[15] 15. Muniz-Junqueira MI, Prata A, Tosta CE. T cell- dependent immunodepression in vivo in Schistosoma mansoni infected patients. Revista da Sociedade Brasileira de Medicina Tropical 23:27-31,1990.

[16] 16. Muniz-Junqueira MI, Prata A,Tosta CE. Phagocytic and bactericidal function of mouse macrophages to Salmonella typhimurium in schistosomiasis mansoni. The American Journal of Tropical Medicine and Hygiene 46:132-136,1992.

[17] 17. Muniz-Junqueira MI, Tavares-Neto J, Ataide M, Prata A, Tosta CE. Specific treatment of hepatosplenic schistosomiasis can increase T- lymphocyte reactivity. Revista da Sociedade Brasileira de Medicina Tropical 24:97-99,1991.

[18] 18. Nash TE, Cheever AW, Ottesen EA, Cook JA. Schistosome infections in humans: perspectives and recent findings. Annals of Internal Medicine 97:740-754,1982.

[19] 19. Nash TE, Ottensen EA, Cheever AW Antibody response to a polysaccharide antigen present in the schistosome gut. II. Modulation of antibody response. The American Journal of Tropical Medicine and Hygiene 27:944-950,1978.

[20] 20. Neves J, Lobo Martins NRL. Long duration of septicaemic salmonellosis: 35 cases with 12 implicated species of Salmonella Transactions of the Royal Society of Tropical Medicine and Hygiene 61:541-552,1967.

[21] 21. Prata A. Como caracteriza a forma hepato- esplênica da esquistossomose? In: Resumos do II Simpósio sobre esquistossomose. Salvador, p. 179, 1970.

[22] 22. Rajagopalan P, Kumar R, Malaviya AN. Immunological studies in typhoid fever. I. Immunoglobulins, C3, antibodies, rheumatoid factor and circulating immune complexes in patients with typhoid fever. Clinical and Experimental Immunology 44:68-73,1981.

[23] 23. Rocha H, Kirk JW, Hearey CD. Prolonged Salmonella bacteremia in patients with Schistosoma mansoni infection. Archives of Internal Medicine 128:254-257,1971.

[24] 24. Rocha H, Magnavita M, Silva Teles E, Rebouças G. Atividade antibacteriana do soro de pacientes com forma hepatoesplênica da esquistossomose mansônica. Revista do Instituto de Medicina Tropical de São Paulo 10:364-370,1968.

[25] 25. Shikanai-Yasuda MA, Ferri RG, Yasuda PH, Fava Neto C, Silva GR, Ferreira JM. Níveis de aglutininas antitifoídicas em esquistossomóticos hepatoesplênicos. Revista de Saúde Pública de São Paulo 16:107-113,1982.

[26] 26. Shikanai-Yasuda MA,Yasuda PH, Ferri RG, Castilho EA, Shiroma M. Resposta imune humoral a vacina antitifoídica em esquistossomose mansônica hepatoesplênica. Revista do Instituto de Medicina Tropical de São Paulo 24:198-204,1982.

[27] 27. Smithers SR, Doenhoff MJ. Schistosomiasis. In: Cohen S, Warren KS (eds) Immunology of Parasitic Infections, 2nd edition, Blackwell, Oxford, p. 527-607,1982.

[28] 28. Tweardy DJ, Osman GS, El Kholy A, Ellner JJ. Failure of immunosuppressive mechanisms in human Schistosoma mansoni infection with hepatosplenomegaly. Journal of Clinical Microbiology 25:768-773,1987.

[29] 29. Welch H, Mickle FL. A rapid slide test for serological diagnosis of typhoid and paratyphoid fevers. American Journal of Public Health 26:248- 255,1936.

[30] 30. World Health Organization. Biomedical research: a revised code of ethics. World Health Organization Chronicle 30:360-362,1976. 445