Abstract
Pulmonary lesions compatible with adenovirus infection were detected by gross and microscopic examination of autopsy tissues children aged from 5 to 34 months. Hepatic lesions indicative of systemic infection were also found in four of the chisldren. The viral etiology was confirmed in three cases by in-situ hibridization, electro-microscopy and immunofluorescence performed in parafin-embedded tissues, and in one case by cell culture isolation of adenovirus type 2 from nasopharyngeal exudate. Routine testing by methods additional to conventional light microscopy would probably have revealed a larger number of adenovirus infections among the 1.103 autopsy records analyzed in this study.
adenovirus infection; viral pneumonia; childhood pneumonia
Morphological and virological studies in six autopsies of children with adenovirus pneumonia
A. G. P. Garcia1
M. E. F. Fonseca2
M. de Bonis2
H. I. B. Ramos1
Z. P. A. Ferro1
J. P. Nascimento3
FIOCRUZ, Instituto Fernandes Figueira, Departamento de Anatomia Patológica, Rio de Janeiro, Brasil
UFRJ, Instituto de Virologia, Setor de Microscopia Eletrônica, Rio de Janeiro, Brasil
Instituto Oswaldo Cruz, Departamento de Virologia, Rio de Janeiro, Brasil
Pulmonary lesions compatible with adenovirus infection were detected by gross and microscopic examination of autopsy tissues children aged from 5 to 34 months. Hepatic lesions indicative of systemic infection were also found in four of the chisldren. The viral etiology was confirmed in three cases by in-situ hibridization, electro-microscopy and immunofluorescence performed in parafin-embedded tissues, and in one case by cell culture isolation of adenovirus type 2 from nasopharyngeal exudate. Routine testing by methods additional to conventional light microscopy would probably have revealed a larger number of adenovirus infections among the 1.103 autopsy records analyzed in this study.
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Publication Dates
-
Publication in this collection
01 June 2009 -
Date of issue
Mar 1993
