KIDNEY AND SMALL INTESTINE MORPHOLOGICAL ASPECTS FOLLOWING SYSTEMIC USE OF GANGLIOSIDES
MONTERO EFS,
VON KOSSEL K,
CASTRO LC,
FERREIRA R,
MARINHO LC,
NIGRO AJT
ABSTRACT: Objective: to investigated renal and intestinal repercussions of systemic use of gangliosides. Methods: 18 Wistar isogenic rats were submitted to 7 days gangliosides treatment, with different doses (3, and 9mg.kg-1.day-1), and one group (Sham) was treated with vehicle, via intramuscular. At the end, animals were sacrificed with ether inhalation and their kidneys and a sample of small intestine were removed surgically to perform a histological analysis under light microscopy. Results: It was observed on small intestine that mucosa was preserved with surface covered by a single layer of tall columnar cells. The underlying lamina proprial core contains lymphoid and plasma cells and a connective tissue framework including a lymphatic vessel and a subepithelial capillary. Concerning to kidney, the morphologic evaluation showed normal histologic aspects including glomerular capillary tuft and Bowmans capsule, proximal and distal tubules, collecting duct, interstitium and renal vasculature. Now it is necessary to verify gangliosides effects in a long-term use. Conclusion: There was no morphological changes in any studied groups neither in kidneys nor in small bowel, following short term use of gangliosides
Publication Dates
-
Publication in this collection
14 Mar 2001 -
Date of issue
2000
