C. coclensis
|
Extract |
Leaves (H2O) |
Hypotensive effect on normotensive and hypertensive rats |
40 mg/Kg |
ND |
ND |
Gárcia-González et al. 1998, Gárcia-González et al. 1996 |
C. columnaris
|
Extract |
Stems (CH3OH:CH2Cl2) |
Antimicrobial activity against Enterococcus faecalis (EF) and Pseudomonas aeruginosa (PA) |
ND |
ND |
EF: MIC = 180 μg/mL; MBC = 270 μg/mL PA: MIC = 140 μg/mL; MBC > 200 μg/mL |
Suffredini et al. 2006SUFFREDINI IB, PACIENCIA ML, NEPOMUCENO DC, YOUNES RN VARELLA AD. 2006. Antibacterial and cytotoxic activity of Brazilian plant extracts of Clusiaceae. Mem Inst Oswaldo Cruz 101(3): 287-290., Bittar et al.2000 |
I3, II8-Binaringerin (1) |
Leaves (CH3OH) |
Antinociceptive effect in mice |
ND |
IC50 (writhing test)= 22µmol/kg IC50 (formalin test) = 28µmol/kg |
ND |
C. grandiflora
|
Resins |
Staminate flowers |
Antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, and Candida albicans in bioautography assay |
ND |
ND |
ND |
Porto et al. 2000PORTO AL, MACHADO SM, OLIVEIRA CM, BITTRICH V, AMARAL MC MARSAIOLI AJ. 2000. Polyisoprenylated benzophenones from Clusia floral resins. Phytochemistry 55(7): 755-768., Lokvam et al. 2000LOKVAM J, BRADDOCK JF, REICHARDT PB CLAUSEN TP. 2000. Two polyisoprenylated benzophenones from the trunk latex of Clusia grandiflora (Clusiaceae). Phytochemistry 55(1): 29-34., Diaz-Carballo et al. 2012 |
Resins |
Pistillate flowers |
Antimicrobial activity against S. aureus and B. subtilis, in bioautography assay |
ND |
ND |
ND |
Nemorosone II (2) |
Trunk latex (C2H5)2O |
Antimicrobial activity against Paenibacillus larvae and P. alvei in bioautography assay |
ND |
ND |
ND |
Chamone I (3) |
Pistillate flower (C2H5)2 O |
7-epi-nemorosone (4) |
Floral resins (C2H5)2O |
Anticancer activity in prostate carcinoma |
ND |
IC50 (LNCaP WT) = 4.12±0.19µM IC50 (LNCaP ETO MDR1+) = 4.81±0.68µM IC50 (PC-3 WT) = 5.01±0.07µM IC50 (PC-3 ETO MDR1+) = 5.1±0.1µM IC50 (DU-145) = 7.3±0.07µM IC50 (DU-145 MDR1+) = 6.8±0.45µM |
ND |
C. guatemalensis
|
Extract |
Leaves (CH3OH:CH2Cl2) |
Inhibition of HIV-1 virus reverse transcriptase |
50 µg/mL |
IC50 (HIV-1 RT) = 42 µg/ml IC50 (HIV-1 IIIb/LAV) = 124.1 µg/ml |
ND |
Huerta-Reyes et al. 2004HUERTA-REYES M, BASUALDO MDEL C, LOZADA L, JIMENEZ-ESTRADA M, SOLER C REYES-CHILPA R. 2004. HIV-1 inhibition by extracts of Clusiaceae species from Mexico. Biol Pharm Bull 27(6): 916-920.
|
C. massoniana
|
50 µg/mL |
ND |
C. quadrangula
|
50 µg/mL |
ND |
C. hilariana
|
Extract |
Staminate flowers (CH3OH) |
Antifeedant effect on Rhodnius prolixus larvae, and promotion of ecdise delay. |
100μg/mL |
ND |
ND |
Kelecom et al. 2002KELECOM A, REIS GL, FEVEREIRO PC, SILVA JG, SANTOS MG, MELLO NETO CB, GONZALEZ MS, GOUVEA RC ALMEIDA GS. 2002. A multidisciplinary approach to the study of the fluminense vegetation. An Acad Bras Cienc 74: 171-181.
|
Oleanolic acid (5) |
Toxicity on R. prolixus larvae, and promotion of ecdise delay. |
1, 10 e 100μg/mL |
Nemorosone (6) |
Promotion of ecdise delay on R. prolixus larvae |
10μg/mL |
C. insignis
|
Resins |
Staminate flowers |
Antimicrobial activity against S. aureus and B. subtilis in bioautography assay |
ND |
ND |
ND |
Porto et al. 2000PORTO AL, MACHADO SM, OLIVEIRA CM, BITTRICH V, AMARAL MC MARSAIOLI AJ. 2000. Polyisoprenylated benzophenones from Clusia floral resins. Phytochemistry 55(7): 755-768.
|
C. lanceolata
|
Resins |
Staminate flowers |
Antimicrobial activity against S. aureus, B. subtilis and C. albicans in bioautography assay |
ND |
ND |
ND |
Porto et al. 2000PORTO AL, MACHADO SM, OLIVEIRA CM, BITTRICH V, AMARAL MC MARSAIOLI AJ. 2000. Polyisoprenylated benzophenones from Clusia floral resins. Phytochemistry 55(7): 755-768.
|
Extract |
Non-galled and galled leaves (CH3OH) |
Antioxidant activity in β-carotene/linoleic acid assay |
57 μg/mL |
ND |
ND |
Ferreira et al. 2014FERREIRA RO, JUNIOR ARC, SILVA TMG, CASTRO RN, SILVA TMS CARVALHO MG. 2014. Distribution of metabolites in galled and non-galled leaves of Clusia lanceolata and its antioxidant activity. Rev Bras Farmacogn 24(6): 617-625.
|
C. nemorosa
|
Resins |
Hermaphrodite flowers |
Antimicrobial activity against S. aureus and B. subtilis in bioautography assay |
ND |
ND |
ND |
Porto et al. 2000PORTO AL, MACHADO SM, OLIVEIRA CM, BITTRICH V, AMARAL MC MARSAIOLI AJ. 2000. Polyisoprenylated benzophenones from Clusia floral resins. Phytochemistry 55(7): 755-768.
|
Extract |
Leaves (C6H14) |
Anti-inflammatory and antinociceptive effects on male Swiss mice |
62 mg/kg |
IC50 (writhing test) = 62mg/kg |
ND |
Ferro et al. 2013FERRO JNS, SILVA JP, CONSERVA LM BARRETO E. 2013. Leaf extract from Clusia nemorosa induces an antinociceptive effect in mice via a mechanism that is adrenergic systems dependent. Chin J Nat Med 11(4): 385-390.
|
Inhibition of protein exudation, leukocyte influx and TNFα levels on pleurisy induced by carrageenan on male Swiss mice |
100 and 200 mg/kg |
ND |
ND |
Farias et al. 2012FARIAS JA ET AL. 2012. Modulation of inflammatory processes by leaves extract from Clusia nemorosa both in vitro and in vivo animal models. Inflammation 35(2): 764-771.
|
Betulinic acid (7) |
Roots (H2O) |
Decrease of body weights, abdominal fat accumulation, blood glucose, plasma triglycerides, and total cholesterol on male Swiss mice |
50 mg/L |
ND |
ND |
Melo et al. 2009MELO CL ET AL. 2009. Betulinic acid, a natural pentacyclic triterpenoid, prevents abdominal fat accumulation in mice fed a high-fat diet. J Agric Food Chem 57(19): 8776-8781.
|
C. palmana
|
Extract |
Leaves and flower buds (CH3CH2OH:H2O); Leaves and fruits (CH3CO2C2H5 fraction) |
Neutralization of the hemorrhagic effect induced by Bothrops asper venom in rats |
1:50 (poison / extract ratio) |
ND |
ND |
Castro et al. 1999CASTRO O, GUTIERREZ JM, BARRIOS M, CASTRO I, ROMERO M UMANA E. 1999. Neutralization of the hemorrhagic effect induced by Bothrops asper (Serpentes: Viperidae) venom with tropical plant extracts. Rev Biol Trop 47(3): 605-616.
|
C. paralicola
|
Clusiparalicoline A (8) |
Roots (CH3CH2OH) |
Scission-promoting activity on DNA strands; cytotoxicity in KB cells; growth promotion of neuritas in fetal cortical neurons of rats. |
neurite outgrowth promoting activity at 1.0 M |
ND |
ND |
Seo et al. 1999SEO EK, HUANG L, WALL ME, WANI MC, NAVARRO H, MUKHERJEE R, FARNSWORTH NR KINGHORN AD. 1999. New biphenyl compounds with DNA strand-scission activity from Clusia paralicola. J Nat Prod 62(11): 1484-1487., Takaoka et al. 2002TAKAOKA S, NAKADE K FUKUYAMA Y. 2002. The first total synthesis and neurotrophic activity of clusiparalicoline A, a prenylated and geranylated biaryl from Clusia paralicola. Tetrahedron Lett 43(39): 6919-6923.
|
Clusiparalicoline B (9) |
Scission-promoting activity on DNA strands; cytotoxicity in the KB cells |
|
|
ND |
|
Clusiparalicoline C (10) |
cytotoxicity in the KB cells |
|
|
ND |
|
Extract |
Unripe fruits (CH3CH2OH) |
Antioxidant activity |
ND |
EC50(DPPH) = 12.7±0.1; EC50(ABTS) = 7.4±0.4; |
ND |
Oliveira et al. 2012OLIVEIRA RF, CAMARA CA , AGRAB MF SARMENTO TMS. 2012. Biflavonoids from the Unripe Fruits of Clusia paralicola and their Antioxidant Activity. Nat Prod Commun 7(12): 1597-1600
|
C. renggerioides
|
Resins |
Staminate flowers |
Antimicrobial activity against S. aureus and B. subtilis in bioautography assay |
ND |
ND |
ND |
Porto et al. 2000PORTO AL, MACHADO SM, OLIVEIRA CM, BITTRICH V, AMARAL MC MARSAIOLI AJ. 2000. Polyisoprenylated benzophenones from Clusia floral resins. Phytochemistry 55(7): 755-768.
|
C. rosea
|
Guttiferone E (11) and xanthochymol (12) |
Leaves (CH2Cl2:CH3OH) |
Inhibition of the cytopathic effects of HIV virus in human lymphoblastoid cells |
ND |
1-10 µg/mL |
ND |
Gustafson et al. 1992GUSTAFSON K, BLUNT J, MUNRO M, FULLER R, MCKEE T, CARDELLINA J, MCMAHON J, CRAGG G BOYD M. 1992. The guttiferones, HIV-inhibitory benzophenones from Symphonia globulifera, Garcinia livingstonei, Garcinia ovalifolia and Clusia rosea. Tetrahedron 48: 10093-10102.
|
C. rosea
|
Nemorosone (6) |
Floral resin (CH3CH2OH) |
Cytotoxicity against human cancer cell lines |
ND |
IC50(HELA): 3.3±0.17µM; 1.6±0.08µg/mL IC50(HeP-2): 3.1±0.17µM; 1.5±0.08µg/mL IC50(PC-3): 7.2±1.3µM; 3.6±0.65µg/mL IC50(U251): 3.9±1.4µM; 1.9±0.70µg/mL IC50 (neuroblastoma cells): 3.10±0.15 - 6.3±0.21µM IC50 (MCF-7): 0.03 - 0.1µM |
ND |
Cuesta-Rubio et al. 2002CUESTA-RUBIO O, FRONTANA-URIBE BA, RAMÍREZ-APAN T CÁRDENAS J. 2002. Polyisoprenylated benzophenones in cuban propolis; biological activity of nemorosone. J Biosci 57(3-4): 372-378., Díaz-Carballo et al. 2008DÍAZ-CARBALLO D, MALAK S, BARDENHEUER W, FREISTUEHLER M REUSCH HP. 2008. Cytotoxic activity of nemorosone in neuroblastoma cells. J Cell Mol Med 12(6B): 2598-2608., Popolo et al. 2011POPOLO A, PICCINELLI AL, MORELLO S, SORRENTINO R, OSMANY CR, RASTRELLI L PINTO A. 2011. Cytotoxic activity of nemorosone in human MCF-7 breast cancer cells. Can J Physiol Pharmacol 89(1): 50-57.
|
7-epi-nemorosone (4) |
Resins of pistillate flowers |
Antiestrogenic activity |
10, 20 and 40 μg/well |
ND |
ND |
Camargo et al. 2013CAMARGO MS ET AL. 2013. Evaluation of estrogenic, antiestrogenic and genotoxic activity of nemorosone, the major compound found in brown Cuban propolis. BMC Complement Med 13: 201.
|
C. spiritu-sanctensis
|
Nemorosone (6) |
Resins of staminate flowers |
Antimicrobial activity against S. aureus and B. subtilis in bioautography assay |
ND |
ND |
ND |
Porto et al. 2000PORTO AL, MACHADO SM, OLIVEIRA CM, BITTRICH V, AMARAL MC MARSAIOLI AJ. 2000. Polyisoprenylated benzophenones from Clusia floral resins. Phytochemistry 55(7): 755-768.
|
C. torresii
|
Extracts |
Leaves and flowers (CH3CH2OH:H2O) Leaves and fruits (CH3CO2C2H5 fraction) |
Neutralization of the hemorrhagic effect induced by B. asper venom in rats |
1:50 (poison / extract ratio) |
ND |
ND |
Castro et al. 1999CASTRO O, GUTIERREZ JM, BARRIOS M, CASTRO I, ROMERO M UMANA E. 1999. Neutralization of the hemorrhagic effect induced by Bothrops asper (Serpentes: Viperidae) venom with tropical plant extracts. Rev Biol Trop 47(3): 605-616.
|
Clusianone (13) |
Fruits (C6H14) |
Inhibition of HIV-1 virus infection in lymphoblastoid T cells (C8166) |
ND |
IC50 = 0.020±0.003 µM |
ND |
Piccinelli et al. 2005PICCINELLI AL, CUESTA-RUBIO O, CHICA MB, MAHMOOD N, PAGANO B, PAVONE M, BARONE V RASTRELLI L. 2005. Structural revision of Clusianone and 7-epi-Clusianone and anti-HIV activity of polyisoprenylated benzophenones. Tetrahedron 61(34): 8206-8211.
|
|
7-epi-clusianone (14) |
ND |
IC50 = 2.0±0.07 µM |
ND |
C. weddelliana
|
Resins |
Staminate flowers |
Antimicrobial activity against S. aureus and B. subtilis in bioautography assay |
ND |
ND |
ND |
Porto et al. 2000PORTO AL, MACHADO SM, OLIVEIRA CM, BITTRICH V, AMARAL MC MARSAIOLI AJ. 2000. Polyisoprenylated benzophenones from Clusia floral resins. Phytochemistry 55(7): 755-768.
|
C. fluminensis
|
Extract |
Stems; Leaves; Fruits (H2O) |
Antiophidic |
|
|
|
Da Silva et al. 2019DA SILVA AR, ANHOLETI MC, PIETROLUONGO M, SANCHEZ EF, VALVERDE AL, DE PAIVA SR, FIGUEIREDO MR, KAPLAN MAC FULY AL. 2019. Utilization of the Plant Clusia fluminensis Planch Triana Against Some Toxic Activities of the Venom of Bothrops jararaca and B. jararacussu Snake Venom Toxic Activities. Curr Top Med Chem 19(22): 1990-2002.
|
Zeaxanthin (15) |
Fruits (not described) |
Antioxidant and macular degeneration protector. |
|
|
|
Mazza et al. 2019MAZZA KEL, SANTIAGO MCPA, PACHECO S, NASCIMENTO LSM, BRAGA ECO, MARTINS VC, CUNHA CP, GODOY RLO BORGUINI RG. 2019. Determinação de Substâncias Bioativas em Arilos dos Frutos de Clusia fluminensis Planch. Triana. Rev Virtual Quim 11(1): 3-17.
|
Extract |
Staminate flowers (C6H14) Fruits (C6H14) |
Significant reduction of the survival of the insect Oncopeltus fasciatus |
1.0 mg/mL (1.0µg/ insect) |
ND |
ND |
Duprat et al. 2017DUPRAT RC ET AL. 2017. Laboratory evaluation of Clusia fluminensis extracts and their isolated compounds against Dysdercus peruvianus and Oncopeltus fasciatus. Rev Bras Farmacogn 27: 59-66.
|
Clusianone (13) |
Floral extract (C6H14) |
Reduction on the survival of the insect Dysdercus peruvianus |
0.7 mg/mL (0.7µg/ insect) |
Lanosterol (16) |
Fruit extract (C6H14) |
Significant reduction on both survival and development of the insects O. fasciatus and D. peruvianus |
C. fluminensis
|
Extract |
Leaves (C6H14; CH3OH) |
Inhibitory effect of on proteolysis caused by B. jararaca venom |
venom /extract ratio: 1:5; 1:10; 1:20; and 1:50 |
IC50(hexane): 567μg/mL IC50(methanol): 447μg/mL |
ND |
Oliveira et al. 2014OLIVEIRA EC, ANHOLETI MC, DOMINGOS TF, FAIOLI CN, SANCHEZ EF, DE PAIVA SR FULY AL. 2014. Inhibitory effect of the plant Clusia fluminensis against biological activities of Bothrops jararaca snake venom. Nat Prod Commun (1): 21-25.
|
Stems (CH3OH) ((CH3)2CO) |
IC50(methanol): 245μg/mL IC50(acetone): 180μg/mL |
Fruits (C6H14) ((CH3)2CO) |
IC50(n-hexane): 736μg/mL IC50(acetone): 90μg/mL |
Staminate flowers (C6H14; CH2Cl2) |
IC50(n-hexane): 220μg/mL IC50(dichloromethane): 630μg/mL |
Extract |
Staminate flowers (C6H14) |
Significant delay on the development of Aedes aegypti |
50 mg/L |
ND |
ND |
Anholeti et al. 2015aANHOLETI MC, DUPRAT RC, FIGUEIREDO MR, KAPLAN MA, SANTOS MG, GONZALEZ MS, RATCLIFFE NA, FEDER D, PAIVA SR MELLO C. B. 2015a. Biocontrol evaluation of extracts and a major component, Clusianone, from Clusia fluminensis Planch. Triana against Aedes aegypti. Mem Inst Oswaldo Cruz 110(5): 629-635.
|
Clusianone (13) |
Staminate flowers (C6H14) |
Significant inhibition of survival and complete blockage of development Ae. aegypti |
C. criuva
|
Extracts |
Leaves (C6H14; CH3OH) |
Antioxidant activity in DPPH assay |
ND |
EC50(n-hexane): 34.66 ± 19.42 g extract/g DPPH EC50(methanol): 12.54 ± 1.43 g extract/g DPPH |
ND |
Da Silva et al. 2017DA SILVA KMM, NÓBREGA AB, LESSA B, ANHOLETI MC, LOBÃO AQ, VALVERDE AL, PAIVA SR JOFFILY A. 2017. Clusia criuva Cambess. (Clusiaceae): anatomical characterization, chemical prospecting and antioxidant activity. An Acad Bras Cienc 89: 1565-1578.
|
Pericarp (C6H14; CH3OH) |
EC50(n-hexane): 10.94 ± 0.36 g extract/g DPPH EC50(methanol): 5.01 ± 0.16g extract/g DPPH |
Seeds (C6H14; CH3OH) |
EC50(n-hexane): 8.32 ± 0.30g extract/g DPPH EC50(methanol): 4.06 ± 1.12g extract/g DPPH |
C. burlemarxii
|
Extract |
Leaves (CH3CH2OH) |
Antimicrobial activity against B. subtilis and S. aureus |
ND |
ND |
MIC (B. subtilis): 31.25μg/mL MIC (S. aureus): 62.50μg/mL |
Ribeiro et al. 2011RIBEIRO PR, FERRAZ CG, GUEDES ML, MARTINS D CRUZ FG. 2011. A new biphenyl and antimicrobial activity of extracts and compounds from Clusia burlemarxii. Fitoterapia 82 (8): 1237-1240.
|
|
Trunk (CH3OH) |
Antimicrobial activity against B. subtilis, Streptococcus mutans and Micrococcus luteus |
|
|
MIC (B. subtilis): 62.50μg/mL MIC (S. mutans): 62.50μg/mL MIC (M. luteus): 31.25μg/mL |
|
2,2-dimethyl-3,5-dihydroxy-7-(4-hydroxyphenyl)chromane (17) |
Trunk (CH3OH) |
Antimicrobial activity against B. subtilis, S. aureus, S. mutans and M. luteus |
ND |
ND |
MIC (B. subtilis): 100μg/mL MIC (S. aureus): 50μg/mL MIC (S. mutans): 100μg/mL MIC (M. luteus): 25μg/mL |
|
|
Lyoniresinol (18) |
Leaves (CH3CH2OH) |
Antimicrobial activity against S. aureus |
MIC (S. aureus): 25μg/mL |
|
Rhamnopyranosyl kaempferol (19) |
Antimicrobial activity against B. subtilis and S. aureus |
MIC (B. subtilis): 50μg/mL MIC (S. aureus): 100μg/mL |
C. gundlachii
|
Gundlachiione A (20) |
Fruits (CH3OH) |
Leishmanicidal activity against P. falciparum |
ND |
IC50(promastigote): 11.30μg/mL IC50(amastigote): 0.84μg/mL |
ND |
Zhang et al. 2018ZHANG J, ZHAO J, SAMOYLENKO V, JAIN S, TEKWANI BL, MUHAMMAD I. 2018. New Polyisoprenylated Polycyclic Phloroglucines from Clusia gundlachii. Nat Prod Commun 13(3): 361-365.
|
Gundlachiione B (21) |
IC50(promastigote): 30.12μg/mL IC50(amastigote): 5.92μg/mL |
Gundlachiione C (22) |
IC50(promastigote): 9.63μg/mL IC50(amastigote): 2.32μg/mL |
C. latipes
|
Extract |
Leaves (C6H14; CH₃CO2C₂H₅; CH3OH) |
Cytotoxic activity against human cancer cell lines (PC-3, RKO, D-384 and MCF-7) |
50μg/ml |
ND |
ND |
Bailón-Moscoso et al. 2016BAILÓN-MOSCOSO N, ROMERO-BENAVIDES JC, SORDO M, VILLACÍS J, SILVA R, CELI L, MARTÍNEZ-VÁZQUEZ M OSTROSKY-WEGMAN P. 2016. Phytochemical study and evaluation of cytotoxic and genotoxic properties of extracts from Clusia latipes leaves. Rev Bras Farmacogn 26(1): 44-49.
|
Clusia minor
|
Extract |
Leaves (CH2OH) |
Antinociceptive effect on mice |
150 and 300 mg/kg |
ND |
ND |
Mangas et al. 2019MANGAS R, REYNALDO G, VECCHIA MT, AVER K, PIOVESAN LG, BELLO A, RODEIRO I, MALHEIROS A, SOUZA MM MENENDEZ R. 2019. Gas Chromatography/Mass Spectrometry characterization and antinociceptive effects of the ethanolic extract of the leaves from Clusia minor L. J Pharm Pharmacogn Res 7: 21-30.
|
Clusia flava
|
Extract |
Leaves (CH3OH) |
Leishmanicidal activity against P. falciparum |
ND |
IC50(promastigote): 32μg/mL |
ND |
Peraza-Sánchez et al. 2007PERAZA-SÁNCHEZ SR, CEN-PACHECO F, NOH-CHIMAL A, MAY-PAT F, SIMÁ-POLANCO P, DUMONTEIL E, GARCÍA-MISS MR MUT-MARTÍN M. 2007. Leishmanicidal evaluation of extracts from native plants of the Yucatan peninsula. Fitoterapia 78(4): 315-318.
|
C. pernanbucensis
|
Extract |
Stem bark (CH₃CO2C₂H₅)) |
Leishmanicidal activity against P. falciparum |
ND |
IC50(amastigote): 65μg/mL |
ND |
Silva et al. 2013SILVA EA, FILHA RF, SILVEIRA L, LOPES ED, PAULA N, BRAZ-FILHO J LAILA RE. 2013. Clusiaxanthone and Tocotrienol Series from Clusia pernambucensis and their Antileishmanial Activity. J Braz Chem Soc 24: 1314-1324.
|
Clusiaxanthone (23) |
IC50(amastigote): 66.9μM |
C. amazonica
|
Extract |
Leaves and stems (H2O) |
Leishmanicide |
|
|
|
Odonne et al. 2009ODONNE G, BOURDY G, CASTILLO D, ESTEVEZ Y, LANCHA-TANGOA A, ALBAN-CASTILLO J, DEHARO E, ROJAS R, STIEN D SAUVAIN M. 2009. Ta’ta’, Huayani: perception of leishmaniasis and evaluation of medicinal plants used by the Chayahuita in Peru. Part II. J Ethnopharmacol 126(1): 149-1458.
|