5161 |
Hepatitis B |
5 |
1.41e-05 |
CASP3, CREBBP, EP300, JUN, SMAD4 |
5200 |
Pathways in cancer |
6 |
1.41e-05 |
CASP3, CREBBP, EP300, JUN, SMAD4, XIAP |
4350 TGF-beta signaling pathway |
4 |
3.12e-05 |
CREBBP, EP300, SMAD4, SP1 |
5166 |
HTLV-I infection |
5 |
7.35e-05 |
CREBBP, EP300, JUN, SMAD4, XIAP |
4310 |
Wnt signaling pathway |
4 |
0.000178 |
CREBBP, EP300, JUN, SMAD4 |
5016 |
Huntington s disease |
4 |
0.000356 |
CASP3, CREBBP, EP300, SP1 |
5168 |
Herpes simplex infection |
4 |
0.000356 |
CASP3, CREBBP, EP300, JUN |
5203 |
Viral carcinogenesis |
4 |
0.000356 |
CASP3, CREBBP, EP300, JUN |
BIOLOGICAL PROCESS (GO)
|
Pathway ID
|
Pathway description
|
Observed gene count
|
False discovery rate
|
Matching proteins in network (labels)
|
GO.0007166 |
cell surface receptor signaling pathway |
12 |
4.86e-07 |
CASP3, CREBBP, EP300, JUN, SKI, SKIL, SMAD3, SMAD4, SP1, TGFBR1, UBC, XIAP |
GO.0007165 |
signal transduction |
11 |
0.00311 |
CASP3, CREBBP, JUN, SKI, SKIL, SMAD3, SMAD4, SP1, TGFBR1, UBC, XIAP |
GO.0071363 |
cellular response to growth factor stimulus |
10 |
7.59e-09 |
CASP3, EP300, JUN, SKI, SKIL, SMAD3, SMAD4, SP1, TGFBR1, UBC |
GO.0007167 |
enzyme-linked receptor protein signaling pathway |
9 |
2.83e-06 |
CASP3, JUN, SKI, SKIL, SMAD3, SMAD4, SP1, TGFBR1, UBC |
GO.0007179 |
transforming growth factor-beta receptor signaling pathway |
8 |
4.38e-10 |
JUN, SKI, SKIL, SMAD3, SMAD4, SP1, TGFBR1, UBC |
GO.0090092 |
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
7 |
1.56e-07 |
SKI, SKIL, SMAD3, SMAD4, TGFBR1, UBC, XIAP |
GO.0017015 |
regulation of transforming growth factor-beta receptor signaling pathway |
6 |
1.56e-07 |
SKI, SKIL, SMAD3, SMAD4, TGFBR1, UBC |
GO.0009952 |
anterior/posterior pattern specification |
5 |
9.86e-05 |
EP300, SKI, SMAD3, SMAD4, TGFBR1 |
GO.0060395 |
SMAD protein signal transduction |
4 |
3.37e-05 |
JUN, SKI, SMAD3, SMAD4 |
MOLECULAR FUNCTION (GO)
|
Pathway ID
|
Pathway description
|
Observed gene count
|
False discovery rate
|
Matching proteins in network (labels)
|
GO.0005515 |
protein binding |
10 |
0.0438 |
CREBBP, EP300, JUN, SKI, SKIL, SMAD3, SMAD4, SP1, TGFBR1, UBC |
GO.0000988 |
transcription factor activity, protein binding |
7 |
5.26e-05 |
CREBBP, EP300, JUN, SKI, SKIL, SMAD3, SMAD4 |
GO.0046332 |
SMAD binding |
6 |
6.47e-09 |
JUN, SKI, SKIL, SMAD3, SMAD4, TGFBR1 |
GO.0001085 |
RNA polymerase II transcription factor binding |
5 |
6.15e-06 |
CREBBP, EP300, JUN, SMAD3, SP1 |
GO.0001102 |
RNA polymerase II activating transcription factor binding |
4 |
1.38e-05 |
CREBBP, EP300, JUN, SMAD3 |
GO.0070412 |
R-SMAD binding |
3 |
0.000145 |
JUN, SMAD3, SMAD4 |
CELLULAR COMPONENT (GO)
|
Pathway ID
|
Pathway description
|
Observed gene count
|
False discovery rate
|
Matching proteins in network (labels)
|
GO.0031981 |
nuclear lumen |
10 |
0.00449 |
CASP3, CREBBP, JUN, SKI, SKIL, SMAD3, SMAD4, SP1, UBC, XIAP |
GO.0005654 |
nucleo plasm |
8 |
0.0446 |
CASP3, JUN, SKI, SKIL, SMAD4, SP1, UBC, XIAP |
GO.0005667 |
transcription factor complex |
6 |
5.61e-05 |
CREBBP, EP300, JUN, SKI, SMAD3, SMAD4 |
GO.0000790 |
nuclear chromatin |
5 |
0.000438 |
CREBBP, JUN, SMAD3, SMAD4, SP1 |
GO.0071141 |
SMAD protein complex |
2 |
0.00132 |
SMAD3, SMAD4 |
PFAM PROTEINS DOMAINS
|
Pathway ID
|
Pathway description
|
Observed gene count
|
False discovery rate
|
Matching proteins in network (labels)
|
PF03166 |
MH2 domain |
2 |
0.0103 |
SMAD3, SMAD4 |
PF03165 |
MH1 domain |
2 |
0.0128 |
SMAD3, SMAD4 |
INTERPRO PROTEINS DOMAINS AND FEATURES
|
Pathway ID
|
Pathway description
|
Observed gene count
|
False discovery rate
|
Matching proteins in network (labels)
|
IPR001132 |
SMAD domain, Dwarfin-type |
2 |
0.00732 |
SMAD3, SMAD4 |
IPR013019 |
MAD homology, MH1 |
2 |
0.00732 |
SMAD3, SMAD4 |
IPR013790 |
Dwarfin |
2 |
0.00732 |
SMAD3, SMAD4 |
IPR003619 |
MAD homology1, Dwarfin-type |
2 |
0.011 |
SMAD3, SMAD4 |
IPR017855 |
SMAD domain-like |
2 |
0.011 |
SMAD3, SMAD4 |
IPR008984 |
SMAD/FHA domain |
2 |
0.0335 |
SMAD3, SMAD4 |