In vivo experimental models
|
↑ miR-27a, miR-155 ↓ miR-143
|
ACE, AT1R |
Heart samples |
Wistar-Kyoto rats Exercise training on treadmill |
39 |
↑ miR-17-3p
|
TIMP-3 PTEN |
Heart samples |
C57Bl/6 mice Ramp swimming training model Voluntary wheel training |
40 |
↑ miR-222 |
HIPK1 |
Heart samples |
Ramp swimming model Voluntary wheel training |
41 |
↑ miR-19b, miR-30e, miR-133b, miR-208a ↓ miR-99b, miR-100, miR-191a, miR-22, miR-181a |
IGF-1 PI3K/AKT/mTOR MAPK |
Heart samples Plasma |
Wistar albino rats Swimming training |
42 |
↑ miR-29a, miR-101a |
TG-β fos COL1A1 |
Heart samples |
Intermittent run exercise |
43 |
↑ miR-27a, miR-27b ↓ miR-143 |
ACE ACE2 |
Heart samples |
Wistar rats Swimming training |
44 |
↑ miR-126 |
PI3KR2 |
Heart samples Plasma |
Zucker rats Swimming training |
26 |
↓ miR-214 |
SERCA2A |
Heart samples |
Wistar rats Resistance training |
23 |
↑ miR-1 ↓ miR-214 |
NCX SERCA2A |
Heart samples |
Wistar rats Swimming training |
27 |
↑ miR-29c ↓ miR-1, miR-133a, miR133b |
COL1A1 COL3A1 |
Heart samples |
Wistar rats Swimming training |
45 |
↑ miR-126 |
SPRED1 PI3KR2 |
Heart samples |
Wistar rats Swimming training |
46 |
↑ miR-21, miR-144, miR-145 ↓ miR-124 |
PTEN PIK3A TSC2 |
Heart samples |
Wistar rats Swimming training |
20 |
↑ miR-336-5p, miR-130b-5p, let7d-3p, miR-466c-5p, miR-324-3p, miR-146b-5p, miR-132-3p, miR-21-5p, miR-187-3p, miR-29b-5p, miR-324-5p, miR-214-5p, miR-140-5p, miR-152-5p, miR-99b-5p, miR-130a-5p, miR-455-5p, miR-27b-3p, miR-23b-3p, miR-652-5p, miR-199a-3p, miR-223-5p, miR-421-3p, miR-27a-5p, miR-24-5p, miR-34a-3p, miR-140-3p, miR-125b-5p, miR-145a-5p, miR-192-5p, miR-139-5p, miR-199a-5p, miR-674-3p, miR-191-5p, miR-28-3p, miR-195-5p, miR-598, miR-429, miR-224, miR-425, miR-221 ↓ miR-701-5p, miR-220, miR-144-3p, miR-694, miR-485-3p, miR-136-5p, miR-384-3p, miR-376c-3p, miR-208b-3p, miR-411-3p, miR-141-5p, miR-1894-3p, miR-9a, miR-687, miR-451-5p |
TNF-α COL1A1 MMP9 PTEN AKT1 AMPK BCL2 |
Heart samples |
Wistar rats Aerobic run training |
22 |
↑ miR-503, miR-465b-5p, miR-542-3p ↓ miR-652 |
|
Heart samples |
C57Bl6 mice Swimming training |
47 |
↓ miR-26b, miR-143 |
IGF1R GATA-4 NFAT1C GSK3B |
Heart samples |
Balb/c mice Aerobic metal wheels training |
48 |
↑ miR-21, miR-30b ↓ miR-1 |
BCL-2 p53 PDCD4 |
Heart samples |
Swimming training |
49 |
↑ miR-23a, miR-27a |
PTEN Casp7 FoxO1 |
Skeletal muscle samples |
Resistance exercise |
50 |
↑ miR-29c ↓ miR-1
|
COL1A1 COL3A1 |
Heart samples |
Swimming training |
51 |
↑ miR-382
|
|
Serum, tissues, and cell samples |
IR mice Aerobic exercise |
25 |
MicroRNAs
|
Targets
|
Source
|
Types of Exercises
|
Reference
|
Clinical studies
|
↑ miR-126, miR-133 |
CPK |
Plasma |
Single symptom-limited spiroergometry test Marathon run Eccentric resistance exercise |
52 |
↓ miR-486 |
PTEN |
Serum |
Systematic-cycling at 70% VO2max |
53 |
↑ miR-1, miR-126, miR-133a, miR-134, miR-146a, miR-208a, miR-499-5p |
CPK NT-proBNP hsCRP |
Plasma |
Marathon run Immediately after run |
21 |
↑ miR-1, miR-133a, miR-206, miR-208b, miR-499 |
|
Plasma |
Marathon run Immediately after run |
54 |
↑ miR-1, miR-133a, miR-206 |
|
Plasma |
Marathon run Immediately after run |
55 |
↑ let-7d-3p, let-7f-3p miR-29a-3p, miR-34a-5p, miR-125b-5pmiR-132-3p, miR-143-3p, miR-148a-3p, miR-223-3p, miR-223-5p miR-424-3p, miR-424-5p |
|
Serum |
Marathon run Immediately after run |
56 |
↑ miR-1, miR-30a, miR-133a ↓ miR-26a, -29b |
|
Plasma |
Marathon run Immediately after run |
57 |
↑ miR-1, miR-133a, miR-206 |
|
Plasma |
Marathon run Immediately after run |
58 |
↑ miR-1, miR-133a, miR-133b, miR-139-5p, miR-143, miR-145, miR-223, miR-330-3p, miR-338-3p, miR-424 ↓ miR-30b, miR-106a, miR-146, miR-151-3p, miR-151-5p, miR-221, miR-652, let-7i ↑ miR-103, miR-107 ↓ miR-21, miR-25, miR-29b, miR-92a, miR-133a, miR-148a, miR-148b, miR-185, miR-342-3p, miR-766, let-7d |
|
Plasma |
Cycle ergometry test 1-3 hs after exercise Systematic endurance cycle ergometry training |
59 |
↑ miR-1, miR-133a, miR-133b, miR-206 miR-485-5p, miR-509-5p, miR-517a miR-518f, miR-520f, miR-522, miR-553, miR-888 |
|
Plasma |
High intensity interval exercise Immediately after |
60 |
↑ miR-181b, miR-214 ↑ miR-1, miR-133a, miR-133b, miR-208b |
|
Plasma |
Uphill treadmill test (concentric) Immediately after Downhill treadmill test (eccentric) 2-6 hs after exercise |
61 |
↑ miR-149 ↓ miR-146a, miR-221 |
|
Serum |
Resistance exercise 3 days after exercise |
62 |
↑ miR-1, miR-133a, miR-133b, miR-206, miR-208b, miR-499 |
|
Plasma |
Systematic resistance training 36-72 hs after training |
63 |
↑ miR-1, miR-133a, miR-133b, miR-181a ↓ miR-9, miR-23a, miR-23b, miR-31 ↑ miR-1, miR-29b |
HDAC4 NRF1 |
Skeletal muscle samples |
Cycle ergometer, Cycling |
64 |
↑ miR-136, miR-200c, miR-376a, miR-377, miR-499b, miR-558 ↓ miR-28, miR-30d, miR-204, miR-330, miR-345, miR-375, miR-449c, miR-483, miR-509, miR-520a, miR-548a, miR-628, miR-653, miR-670, miR-889, miR-1245a, miR-1270, miR-1280, miR-1322, miR-3180 |
|
Skeletal muscle samples |
Resistance training |
65 |
↑ miR-451 ↓ miR-26a, miR-29a, miR-378 |
|
Skeletal muscle samples |
Resistance exercise |
66 |
↑ miR-125a, miR-145, miR-181b, miR-193a, miR-197, miR-212, miR-223, miR-340, miR-365, miR-485, miR-505, miR-520d, miR-629, miR-638, miR-939, miR-940, miR-1225, miR-1238 ↓ let-7i, miR-16, miR-17, miR-18a, miR-18b, miR-20a, miR-20b, miR-22, miR-93, miR- 96, miR-106a, miR-107, miR-126, miR-130a, miR-130b, miR-151, miR-185, miR-194, miR-363, miR-660 |
|
Serum |
Cycle ergometer exercise |
67 |
↑ miR-7, miR-15a, miR-21, miR-26b, miR-132, miR-140, miR-181a, miR-181b, miR-181c, miR-338, miR-363, miR-939, miR-940, miR-1225 ↓ let-7e, miR-23b, miR-31, miR-99a, miR-125a, miR-125b, miR-126, miR-130a, miR-145, miR-151, miR-199a, miR-199b, miR-221, miR-320, miR-451, miR-486, miR-584, miR-652 |
|
PBMC |
Cycle ergometer exercise |
68 |
↑ let-7f, miR-21, miR-29c, miR-223 ↓ let-7f, miR-21, miR-29c, miR-223 |
|
PBMC |
Running exercise |
69 |
↑ miR-7, miR-29a, miR-29b, miR-29c, miR-30e, miR-142, miR-192, miR-338, miR-363, miR-590 ↓ let-7e, miR-126, miR-130a, miR-151, miR-199a, miR-221, miR-223, miR-326, miR-328, miR-652 |
|
PBMC |
Cycle ergometer exercise |
70 |
↑ miR-15a, miR-29b, miR-29c, miR-30e, miR-140, miR-324, miR-338, miR-362, miR-532, miR-660 ↓ miR-23b, miR-130a, miR-151, miR-199a, miR-221 |
|
Serum |
Cycle ergometer exercise |
71 |
↑ miR-1, miR-486, miR-494 |
|
Serum |
(Endurance athletes, runners, cyclists, and triathletes) Cardiopulmonary exercise test |
72 |
↑ miR-21, miR-146a, miR-221, miR-222 ↑ miR-20a, miR-21, miR-146a, miR-221, miR-222 |
|
Serum |
Rowing training, 5Km, 1-3 h per session, 20-24 strokes/min) |
73 |
↑ miR-376a ↓ miR-16, miR-27a, miR-28 |
|
Plasma |
Aerobic run exercise training (4 days/week) |
74 |
↑ miR-19a, miR-19b, miR-20a, miR-26b, miR-143, miR-195 |
p-AKT p-S6K1 |
Serum |
Resistance exercise |
75 |
↑ miR-222 |
HIPK1 |
Plasma |
Bicycle Ergometry Test |
41 |
↑ miR-221 ↓ miR-208b, miR-221, miR-21, miR-146a, miR-210 |
|
Serum |
Basketball Exercise |
76 |