Use of Diuretic Therapy in Patients with Decompensated Heart Failure and Acute Kidney Injury. What to do in this Dilemma?

Calazans, Rafael Marques; Sepulvida, Mariana Bellaguarda de Castro; Quadrado, Egli Belinazzi; Miranda, Roberto Dischinger

doi:10.36660/abc.20210238

Keywords Heart Failure/complications; Renal Insufficiency Chronic/complications; Mortality; Health Public; Aging; Hospitalization; Diuretics; Creatinine; Markers Biological; Lipocalins; Electric Impedance

Heart failure (HF) is a severe public health problem due to its high prevalence, morbidity and mortality.¹ It is the main cause of hospitalization in the United States.² The prevalence of the disease increases with age, making elderly patients even more susceptible to the repercussions of this disease.¹ This increases the importance of precise treatment of HF and its complications, including decompensated HF (dHF).

In patients with dHF, who require diuretic therapy, concomitant acute kidney injury (AKI) is a common finding. The big question when it comes to treatment with diuretics in situations where kidney function is altered is to know the reason for the dysfunction: Is the patient is still congested, requiring optimization of diuretic therapy (type I cardiorenal syndrome)? Or is it a patient whose diuretic therapy was carried out excessively, causing hypovolemia, which led to low renal perfusion (pre-renal AKI) or even an acute tubular necrosis?

This question gains a lot of importance in clinical practice because it implies diametrically opposed therapeutic approaches in both situations: intensifying diuretic therapy and discontinuing diuretics, or even initiating proper venous hydration. And the fact that these patients are often elderly, multicomorbid, in the context of concomitant infection, makes it clinically challenging to interpret the hemodynamic profile. It is hard to find an emergency or intensive care unit doctor that has never been faced with this dilemma.

Previous publications corroborate this issue, with some articles considering congestion as the major factor associated with worsening kidney injury in patients with dHF, indicating a more aggressive diuretic therapy,³^,⁴ while others recognize the potentially harmful effect of aggressive diuretic therapy, including hypovolemia, thus indicating a more cautious diuretic therapy,⁵ especially in elderly patients⁶ (Figure 1).

Figure 1
Schematic representation of the physiopathology and management of diuretic therapy of patients with decompensated heart failure under treatment.

The laboratory and imaging methods commonly available to access the volume and hemodynamic profile are usually of little help in this regard, as there is no method considered to be the gold standard, nor are there any guidelines or protocols as to how best to answer this question. Methods commonly used in ICUs, such as variation in pulse pressure and assessment of collapsibility of superior and inferior vena cava, are validated only for responsiveness to the infusion of fluids and are of little help when it comes to fluid removal, and are only effective in mechanically ventilated patients. B-type natriuretic peptide (BNP) and N-terminal pro b-type natriuretic peptide (NT-ProBNP) plasma levels have a well-established importance in the diagnosis and prognosis of dHF. However, it has been little studied as a tool to access hemodynamic profile in these patients, with a study published showing poor performance.⁷

The article by Villacorta et al.,⁸ reported in the current volume of Arquivos Brasileiros de Cardiologia⁸, investigates whether the mechanism of worsening of renal function after aggressive diuretic treatment in patients with dHF occurs due to congestion or renal tubular injury. The article also assesses whether the presence of AKI during treatment or presence of congestion at discharge are predictors of outcome after an episode of dHF. Altogether, 85 patients were evaluated using NGAL as a marker for renal tubular injury and the hydration index with electrical bioimpedance to define the presence of congestion at discharge. It was found that persistent congestion, not AKI, is associated with worse outcomes in patients hospitalized for dHF; moreover, it showed that AKI was a consequence of congestion, rather than of a renal tubular injury.

The authors finish the article⁸ by showing some publications in favor of aggressive diuretic therapy and conclude that, as long as aggressive reduction of congestion is promoted, AKI will not have any adverse impact on the outcomes.

The article⁸ adds to the current view on the subject mainly in two ways. Firstly, for the simple fact that it discusses this very important and common theme in medical practice, but relatively little debated and studied. Secondly, for bringing some new ways of analyzing the issue, more precisely using NGAL, a marker of kidney injury that is faster and more accurate than creatinine, and the use of electrical bioimpedance to detect subclinical congestion, which would increase the accuracy of assessment and the ability to predict outcomes.

Despite this, because it is a complex issue that is hard to assess with the methods available in medical practice, management of patients with AKI in the context of dHF remains a huge clinical challenge, with many questions and few definitive answers. Therefore, further studies are needed to help understand the subject. In the current scenario, the individualization of cases and the clinical perception of the evaluator are still critical.

Short Editorial related to the article: Worsening Renal Function and Congestion in Patients with Acute Heart Failure: A Study with Bioelectrical Impedance Vector Analysis (BIVA) and Neutrophil Gelatinase-Associated Lipocalin (NGAL)

References

¹ Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, et al. Heart disease and stroke statistics-2018 update: a report from the American Heart Association. Circulation. 2018;137(12):e67-492.
² Heidenreich PA, Albert NM, Allen LA, Bluemke DA, Butler J, Fonarow GC, et al. Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association. Circ Heart Fail. 2013;6(3):606-19.
³ Testani JM, Chen J, McCauley BD, Kimmel SE, Shannon RP. Potential effects of aggressive decongestion during the treatment of decompensated heart failure on renal function and survival. Circulation. 2010;122(3):265-72.
⁴ Grodin JL, Stevens SR, Fuentes LL, Kiernan M, Birati EY, Gupta D, et al. Intensification of medication therapy for cardiorenal syndrome in acute decompensated heart failure. J Card Fail. 2016;22(1):26-32.
⁵ Butler J, Forman DE, Abraham WT, Gottlieb SS, Loh E, Massie BM, et al. Relationship between heart failure treatment and development of worsening renal function among hospitalized patients. Am Heart J. 2004;147(2):331-8.
⁶ Maeder MT, Rickli H, Pfisterer ME, Muzzarelli S, Ammann P, Fehr T, et al. Incidence, clinical predictors, and prognostic impact of worsening renal function in elderly patients with chronic heart failure on intensive medical therapy. Am Heart J. 2012;163(3):407-14.
⁷ Almeida Junior GLG, Clausll N, Garcia MI, Esporcatte R, Rangel FOD, Rocha RM, et al. Natriuretic peptide and clinical evaluation in the diagnosis of heart failure hemodynamic profile: comparison with tissue doppler echocardiography. Arq Bras Cardiol. 2018;110(3):270-7.
⁸ Villacorta H, Villacorta AS, Villacorta LSC, Xavier ALR, Kanaan S, Rohen FM, et al. Agravamento da Função Renal e Congestão em Pacientes com Insuficiência Cardíaca Aguda: Estudo com Análise Vetorial de Bioimpedância Elétrica (BIVA) e Lipocalina Associada à Gelatinase Neutrofílica (NGAL). Arq Bras Cardiol.2021; 116(4):715-724.

Publication Dates

Publication in this collection
16 Apr 2021
Date of issue
Apr 2021

This is an open-access article distributed under the terms of the Creative Commons Attribution License

[1] ¹ Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, et al. Heart disease and stroke statistics-2018 update: a report from the American Heart Association. Circulation. 2018;137(12):e67-492.

[2] ² Heidenreich PA, Albert NM, Allen LA, Bluemke DA, Butler J, Fonarow GC, et al. Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association. Circ Heart Fail. 2013;6(3):606-19.

[3] ³ Testani JM, Chen J, McCauley BD, Kimmel SE, Shannon RP. Potential effects of aggressive decongestion during the treatment of decompensated heart failure on renal function and survival. Circulation. 2010;122(3):265-72.

[4] ⁴ Grodin JL, Stevens SR, Fuentes LL, Kiernan M, Birati EY, Gupta D, et al. Intensification of medication therapy for cardiorenal syndrome in acute decompensated heart failure. J Card Fail. 2016;22(1):26-32.

[5] ⁵ Butler J, Forman DE, Abraham WT, Gottlieb SS, Loh E, Massie BM, et al. Relationship between heart failure treatment and development of worsening renal function among hospitalized patients. Am Heart J. 2004;147(2):331-8.

[6] ⁶ Maeder MT, Rickli H, Pfisterer ME, Muzzarelli S, Ammann P, Fehr T, et al. Incidence, clinical predictors, and prognostic impact of worsening renal function in elderly patients with chronic heart failure on intensive medical therapy. Am Heart J. 2012;163(3):407-14.

[7] ⁷ Almeida Junior GLG, Clausll N, Garcia MI, Esporcatte R, Rangel FOD, Rocha RM, et al. Natriuretic peptide and clinical evaluation in the diagnosis of heart failure hemodynamic profile: comparison with tissue doppler echocardiography. Arq Bras Cardiol. 2018;110(3):270-7.

[8] ⁸ Villacorta H, Villacorta AS, Villacorta LSC, Xavier ALR, Kanaan S, Rohen FM, et al. Agravamento da Função Renal e Congestão em Pacientes com Insuficiência Cardíaca Aguda: Estudo com Análise Vetorial de Bioimpedância Elétrica (BIVA) e Lipocalina Associada à Gelatinase Neutrofílica (NGAL). Arq Bras Cardiol.2021; 116(4):715-724.