Hayward et al. (2012)1818. Hayward R, Lien CY, Jensen BT, Hydock DS, Schneider CM. Exercise training mitigates anthracycline induced chronic cardiotoxicity in a juvenile rat model. Pediatr Blood Cancer. 2012;59(1):149-54. |
Aeróbio Roda de corrida |
Acesso livre 24 h/dia Total: 10 semanas |
2 mg/kg por 7 dias Total = 14 mg/kg durante o exercício |
15 |
52 ± 38 |
17 |
61 ± 29 |
Hydock et al. (2012) (a)1919. Hydock DS, Lien CY, Jensen BT, Parry TL, Schneider CM, Hayward R. Rehabilitative exercise in a rat model of doxorubicin cardiotoxicity. Exp Biol Med. 2012;237(12):1483-92. |
Aeróbio Roda de corrida |
Acesso livre 24 h/dia Total: 10 semanas |
1 mg/kg por 15 dias Total = 15 mg/kg durante o exercício |
15 |
45 ± 3 |
9 |
46 ± 4 |
Hydock et al. (2012) (b)1919. Hydock DS, Lien CY, Jensen BT, Parry TL, Schneider CM, Hayward R. Rehabilitative exercise in a rat model of doxorubicin cardiotoxicity. Exp Biol Med. 2012;237(12):1483-92. |
Aeróbio Roda de corrida |
Acesso livre 24 h/dia Total: 10 semanas |
2,5 mg/kg semanalmente por 6 semanas Total = 15 mg/kg durante o exercício |
10 |
52 ± 5 |
10 |
61 ± 4 |
Calvé et al. (2012) (a)2020. Calvé A, Haddad R, Barama SN, Meilleur M, Sebag IA, Chalifour LE. Cardiac response to doxorubicin and dexrazoxane in intact and ovariectomized young female rats at rest and after swim training. Am J Physiol Heart Circ Physiol. 2012;302(10):H2048-57. |
Aeróbio Nado |
1 h/dia Total: 4 semanas |
3 mg/kg no 26º dia de vida pré-exercício |
8 |
53,1 ± 3,8 |
8 |
49,5 ± 2,2 |
Calvé et al. (2012) (b)2020. Calvé A, Haddad R, Barama SN, Meilleur M, Sebag IA, Chalifour LE. Cardiac response to doxorubicin and dexrazoxane in intact and ovariectomized young female rats at rest and after swim training. Am J Physiol Heart Circ Physiol. 2012;302(10):H2048-57. |
Aeróbio Nado |
1 h/dia Total: 4 semanas |
3 mg/kg no 26º dia de vida pré-exercício |
8 |
47 ± 2,1 |
8 |
51,6 ± 1,7 |
Dolisnky et al. (2013)2121. Dolinsky VW, Rogan KJ, Sung MM, Zordoky BN, Haykowsky MJ, Young ME, et al. Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice. Am J Physiol Endocrinol Metab. 2013;305(2):E243-53. |
Aeróbio Esteira |
10-18 m/min 5 dias/semana Total: 8 semanas |
8 mg/kg por semana por 4 semanas Total = 32 mg/kg pré-exercício |
8 |
23,8 ± 1,0 |
8 |
28,0 ± 0,7 |
Jensen et al. (2013) (a)2222. Jensen BT, Lien CY, Hydock DS, Schneider CM, Hayward R. Exercise mitigates cardiac doxorubicin accumulation and preserves function in the rat. J Cardiovasc Pharmacol. 2013;62(3):263-9. |
Aeróbio Esteira |
13-30 min/m 5º-18º 20-60 min/dia 5 dias/semana Total: 10 semanas |
10 mg/kg dose única pós-exercício |
8 |
50,47 ± 2,77 |
4 |
61,60 ± 7,28 |
Jensen et al. (2013) (b)2222. Jensen BT, Lien CY, Hydock DS, Schneider CM, Hayward R. Exercise mitigates cardiac doxorubicin accumulation and preserves function in the rat. J Cardiovasc Pharmacol. 2013;62(3):263-9. |
Aeróbio Roda de corrida |
Acesso livre 24 h/dia Total: 10 semanas |
10 mg/kg dose única pós-exercício |
8 |
50,47 ± 2,77 |
7 |
58,3 ± 4,33 |
Parry et al. (2015)2323. Parry TL, Hayward R. Exercise training does not affect anthracycline antitumor efficacy while attenuating cardiac dysfunction. Am J Physiol Regul Integr Comp Physiol. 2015;309(6):R675-83. |
Aeróbio Roda de corrida |
Acesso livre 24 h/dia Total: 11 semanas |
12 mg/kg dose única pós-exercício |
6 |
59 ± 6 |
4 |
63 ± 4 |
Lien et al. (2015) (a)2424. Lien CY, Jensen BT, Hydock, DS, Hayward R. Short-term exercise training attenuates acute doxorubicin cardiotoxicity. J Physiol Biochem. 2015;71(4):669-78. |
Aeróbio Esteira |
18-24 m/min Total: 5 dias |
10 mg/kg dose única pós-exercício |
10 |
48 ± 4 |
10 |
56 ± 4 |
Lien et al. (2015) (b)2424. Lien CY, Jensen BT, Hydock, DS, Hayward R. Short-term exercise training attenuates acute doxorubicin cardiotoxicity. J Physiol Biochem. 2015;71(4):669-78. |
Aeróbio Roda de corrida |
Acesso livre 24 h/dia Total: 5 dias |
10 mg/kg dose única pós-exercício |
10 |
48 ± 4 |
10 |
51 ± 5 |
Lien et al. (2015) (c)2424. Lien CY, Jensen BT, Hydock, DS, Hayward R. Short-term exercise training attenuates acute doxorubicin cardiotoxicity. J Physiol Biochem. 2015;71(4):669-78. |
Aeróbio Esteira |
18-24 m/min Total: 5 dias |
15 mg/kg dose única pós-exercício |
13 |
39 ± 6 |
13 |
48 ± 5 |
Lien et al. (2015) (d)2424. Lien CY, Jensen BT, Hydock, DS, Hayward R. Short-term exercise training attenuates acute doxorubicin cardiotoxicity. J Physiol Biochem. 2015;71(4):669-78. |
Aeróbio Roda de corrida |
Acesso livre 24 h/dia Total: 5 dias |
15 mg/kg dose única pós-exercício |
13 |
39 ± 6 |
12 |
45 ± 3 |