Hypertriglyceridemic Waist Phenotype and Changes in the Fasting Glycemia and Blood Pressure in Children and Adolescents Over One-Year Follow-Up Period

Costa, Priscila Ribas de Farias; Assis, Ana Marlúcia Oliveira; Cunha, Carla de Magalhães; Pereira, Emile Miranda; Jesus, Gabriela dos Santos de; Silva, Lais Eloy Machado da; Alves, Wilanne Pinheiro de Oliveira

doi:10.5935/abc.20170067

Acessibilidade / Reportar erro

Brasil

Arquivos Brasileiros de Cardiologia

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

Original Article • Arq. Bras. Cardiol. 109 (01) • July 2017 • https://doi.org/10.5935/abc.20170067 copy

Hypertriglyceridemic Waist Phenotype and Changes in the Fasting Glycemia and Blood Pressure in Children and Adolescents Over One-Year Follow-Up Period

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Background:

The hypertriglyceridemic waist (HTW) phenotype is defined as the simultaneous presence of increased waist circumference (WC) and serum triglycerides (TG) levels and it has been associated with cardiometabolic risk in children and adolescents.

Objective:

The objective was to evaluate the influence of HTW phenotype in the fasting glycemia and blood pressure in children and adolescents over one-year follow-up period.

Methods:

It is a cohort study involving 492 children and adolescents from 7 to 15 years old, both genders, who were submitted to anthropometric, biochemical and clinical evaluation at the baseline, and also after 6 and 12 months of follow-up. Generalized Estimating Equation (GEE) models were calculated to evaluate the longitudinal influence of the HTW phenotype in the glycemia and blood pressure over one-year.

Results:

It was observed a prevalence of 10.6% (n = 52) of HTW phenotype in the students. The GEE models identified that students with HTW phenotype had an increase of 3.87 mg/dl in the fasting glycemia mean (CI: 1.68-6.05) and of 3.67mmHg in the systolic blood pressure (SBP) mean (CI: 1.55-6.08) over one-year follow-up, after adjusting for confounding variables.

Conclusions:

The results of this study suggest that HTW phenotype is a risk factor for longitudinal changes in glycemia and SBP in children and adolescents over one-year follow-up period.

Keywords:
Hypertriglyceridemic Waist, Phenotype; Glycemic Index; Fasting; Blood Pressure; Child; Adolescent; Cohort Studies

	HTW Phenotype N (%)
	Total N	Absent	Present	p value
Gender
– Female	492	255 (88.8)	32 (11.1)	0.620
– Male	492	185 (90.2)	20 (9.8)	0.620
Age
– <10 years	492	124 (90.5)	13 (9.5)	0.620
– ≥ 10 years	492	316 (89.0)	39 (11.0)	0.620
Environmental index
– 3rd tercile	492	177 (88.9)	22 (11.1)	0.770
– 1st e 2nd terciles	492	263 (89.8)	30 (10.2)	0.770
Socioeconomic index
– 3º Tercile	492	206 (94.1)	13 (5.9)	0.003^* * Significant p value for Pearson chi-square; HTW: hypertriglyceridemic waist.
– 1º e 2º Terciles	492	234 (85.7)	39 (14.3)
Maternal education
– ≥ 6 years	439	171 (89.5)	20 (10.5)	0.090
– < 6 years	439	233 (93.9)	15 (6.1)	0.090
Physical activity
– Active	492	133 (86.9)	20 (13.1)	0.113
– Low active/sedentary	492	284 (91.6)	26 (8.4)	0.113
Blood pressure
– < P90	492	324 (91.0)	32 (9.0)	0.467
– ≥ P90		117 (86.0)	19 (14.0)	0.467
Glycemia
– <100mg/dL	492	413 (90.4)	44 (9.6)	0.01^* * Significant p value for Pearson chi-square; HTW: hypertriglyceridemic waist.
– ≥ 100 mg/dL	492	27 (77.1)	8 (22.9)
BMI/age
– < P85	492	369 (94.8)	20 (5.2)	0.000^* * Significant p value for Pearson chi-square; HTW: hypertriglyceridemic waist.
– ≥ P85	492	71 (68.9)	32 (31.1)

	Baseline			After one-year follow-up
	HTW(-)	HTW(+)	p value	HTW (-)	HTW (+)	p value
	Mean (SD)	Mean (SD)	p value	Mean (SD) final	Mean (SD) final	p value
Glycemia (mg/dL)	81.8 (10.2)	86.0 (11.7)	0.003	83.5 (10.3)	86.1 (11.6)	0.04
Systolic BP (mmHg)	101.3 (12.0)	105.1 (12.1)	0.03	101.3 (11.8)	104.1 (11.0)	0.10
Diastolic BP (mmHg)	64.3 (10.1)	66.9 (10.3)	0.09	64.5 (10.6)	66.1 (10.6)	0.09

Sociedade Brasileira de Cardiologia - SBC Avenida Marechal Câmara, 160, sala: 330, Centro, CEP: 20020-907, (21) 3478-2700 - Rio de Janeiro - RJ - Brazil, Fax: +55 21 3478-2770 - São Paulo - SP - Brazil
E-mail: revista@cardiol.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] Mailing Address: Priscila Ribas de Farias Costa, Avenida Araujo Pinho, nº32, Postal Code 40.110-150. Canela, Salvador, BA - Brasil. E-mail: priscilarf@yahoo.com.br

- HTW phenotype Absent PresentQIC_c^* * Generalized Estimating Equation – GEE; ^* * Generalized Estimating Equation – GEE; ^* * Generalized Estimating Equation – GEE;	Fasting glycemia Coefficient (95% CI); p value^* * Generalized Estimating Equation – GEE;
	Crude Reference 3.11 (1.35-4.86); 0.001 128.540	Final model^† † Adjusted by gender, age, maternal education; socioeconomic status and level of physical activity; Reference 3.87 (1.68-6.05); 0.001 112.716
- HTW phenotype Absent PresentQIC_c^‡ ‡ QICC: quasi-likelihood corrected under the criterion of Independence model for.	Systolic Blood Pressure Coefficient (95% CI); p value^* * Generalized Estimating Equation – GEE;
	Crude Reference 2.97 (-0.11- 6.06); 0.06 125.375	Final model^† † Adjusted by gender, age, maternal education; socioeconomic status and level of physical activity; Reference 3.67 (1.55-6.08); 0.02 118.265
- HTW phenotype Absent PresentQIC_c^‡ ‡ QICC: quasi-likelihood corrected under the criterion of Independence model for.	Diastolic Blood Pressure Coefficient (95% CI); p value^* * Generalized Estimating Equation – GEE;
	Crude Reference 1.43 (-1.20- 4.05); 0.28 90.724	Final model^† † Adjusted by gender, age, maternal education; socioeconomic status and level of physical activity; Reference 1.45 (-1.20- 4.10); 0.29 83.872