|
Estudos com alimentos enriquecidos com fitosteróis
|
Gylling et al. (2010)2727 Gylling H, Hallikainen M, Nissinen MJ, Miettinen TA. The effect of a very high daily plant stanol ester intake on serum lipids, carotenoids, and fat-soluble vitamins. Clin Nutr. 2010;29(1):112-8. doi: 10.1016/j.clnu.2009.08.005.
https://doi.org/10.1016/j.clnu.2009.08.0...
|
49 indivíduos com hipercolesterolemia leve a moderada |
Estanóis (spread e bebida) |
8,8 |
10 semanas |
17,1 |
0,01 |
Gylling et al.(2013)3939 Gylling H, Halonen J, Lindholm H, Konttinen J, Simonen P, Nissinen MJ, et al. The effects of plant stanol ester consumption on arterial stiffness and endothelial function in adults: a randomised controlled clinical trial. BMC Cardiovasc Disord. 2013;13:50. doi: 10.1186/1471-2261-13-50.
https://doi.org/10.1186/1471-2261-13-50...
|
92 indivíduos assintomáticos (sem uso de drogas hipolipemiantes) |
Estanóis (spread) |
3 |
6 meses |
10,2 |
0,001 |
Buyuktuncer et al. (2013)4040 Buyuktuncer Z, Fisunoglu M, Guven GS, Unal S, Besler HT. The cholesterol lowering efficacy of plant stanol ester yoghurt in a Turkish population: a double-blind, placebo-controlled trial. Lipids Health Dis. 2013;12:91. doi: 10.1186/1476-511X-12-91.
https://doi.org/10.1186/1476-511X-12-91...
|
70 indivíduos com hipercolesterolemia leve a moderada |
Estanóis (iogurte) |
1,9 |
4 semanas |
6,3 |
0,005 |
Vásquez-Trespalacios & Romero-Palacio (2014)2626 Vásquez-Trespalacios EM, Romero-Palacio J. Efficacy of yogurt drink with added plant stanol esters (Benecol(r), Colanta) in reducing total and LDL cholesterol in subjects with moderate hypercholesterolemia: a randomized placebo controlled crossover trial NCT01461798. Lipids Health Dis. 2014;13:125. doi: 10.1186/1476-511X-13-125.
https://doi.org/10.1186/1476-511X-13-125...
|
40 indivíduos com hipercolesterolemia moderada |
Estanóis (iogurte) |
4 |
4 semanas |
10,3 |
< 0,01 |
Ras et al. (2015)4141 Ras RT, Fuchs D, Koppenol WP, Garczarek U, Greyling A, Keicher C, et al. The effect of a low-fat spread with added plant sterols on vascular function markers: results of the Investigating Vascular Function Effects of Plant Sterols (INVEST) study. Am J Clin Nutr. 2015;101(4):733-41. doi:10.3945/ajcn.114.102053.
https://doi.org/10.3945/ajcn.114.102053...
|
240 indivíduos com hipercolesterolemia |
Esteróis (spread) |
3 |
12 semanas |
6,7 |
< 0,05 |
Párraga-Martinez et al. (2015)2525 Párraga-Martínez I, López-Torres-Hidalgo JD, Del Campo-Del Campo JM, Galdón-Blesa MP, Precioso-Yáñez JC, Rabanales-Sotos J, et al. Long-term effects of plant stanols on the lipid profile of patients with hypercholesterolemia. A randomized clinical trial. Rev Esp Cardiol. 2015;68(8):665-71. doi: 10.1016/.rec.2014.07035.
https://doi.org/10.1016/.rec.2014.07035...
|
182 adultos com hipercolesterolemia |
Estanóis (iogurte) |
2 |
12 meses |
11 |
0,01 |
|
Estudos com cápsulas ou comprimidos
|
Maki et al. (2012)3232 Maki KC, Lawless AL, Reeves MS, Dicklin MR, Jenks BH, Shneyvas ED, et al. Lipid-altering effects of a dietary supplement tablet containing free plant sterols and stanols in men and women with primary hypercholesterolaemia: a randomized, placebo-controlled crossover trial. Int J Food Sci Nutr. 2012;63(4):476-82. doi: 10.3109/09637486.2011.636345.
https://doi.org/10.3109/09637486.2011.63...
|
32 indivíduos com hipercolesterolemia primária |
Esteróis/Estanóis (comprimido) |
1,8 |
6 semanas |
4,9 |
< 0,05 |
Maki et al. (2013)2929 Maki KC, Lawless AL, Reeves MS, Kelley KM, Dicklin MR, Jenks BH, et al. Lipid effects of a dietary supplement softgel capsule containing plant sterols/stanols in primary hypercholesterolemia. Nutrition. 2013;29(1):96-100. doi: 10.1016/j.nut.2012.05.002.
https://doi.org/10.1016/j.nut.2012.05.00...
|
28 indivíduos com hipercolesterolemia primária |
Esteróis/Estanóis (cápsula softgel) |
1,8 |
6 semanas |
9,2 |
< 0,001 |
Ottestad et al. (2013)3030 Ottestad I, Ose L, Wennersberg MH, Granlund L, Kirkhus B, Retterstol K. Phytosterol capsules and serum cholesterol in hypercholesterolemia: a randomized controlled trial. Atherosclerosis. 2013;228(2):421-5. doi: 10.1016/j.atherosclerosis.2013.03.001.
https://doi.org/10.1016/j.atherosclerosi...
|
41 indivíduos com colesterol total de 180 – 300 mg/dL |
Esteróis/Estanóis (cápsula softgel) |
2 |
4 semanas |
2,7 |
0,32 |
McKenney et al. (2014)3131 McKenney JM, Jenks BH, Shneyvas E, Brooks JR, Shenoy SF, Cook CM, et al. A softgel dietary supplement containing esterified plant sterols and stanols improves the blood lipid profile of adults with primary hypercholesterolemia: a randomized, double-blind, placebo-controlled replication study. J Acad Nutr Diet. 2014;114(2):244-9. doi: 10.1016/j.jand.2013.09.023.
https://doi.org/10.1016/j.jand.2013.09.0...
|
30 adultos com hipercolesterolemia familiar |
Esteróis/Estanóis (cápsula softgel) |
1,8 |
6 semanas |
4,3 |
< 0,01 |
