Selvester QRS Score is a Predictor of Mortality in Heart Failure with Preserved Ejection Fraction

Central Illustration

: Selvester QRS Score is a Predictor of Mortality in Heart Failure with Preserved Ejection Fraction

Abstract

Background  The Selvester QRS (S-QRS) score on a 12-lead electrocardiogram (ECG) is associated with both the amount of myocardial scar and poor prognosis in myocardial infarction patients. However, its prognostic value in heart failure (HF) with preserved ejection fraction (HFpEF) is unknown.

Objective  This study aims to investigate the predictive value of the S-QRS score for mortality in HFpEF.

Methods  359 patients were retrospectively enrolled in this study. Electrocardiographic, echocardiographic, and laboratory features of the patients were recorded. The simplified S-QRS score was measured and recorded. The mean follow-up time of the patients was 38.1±9.5 months. Statistical significance was set at p < 0.05.

Results  Of 359 patients, 270 were in the survivor group, and 89 were in the deceased group. Age, Hs-CRP, troponin, pro-BNP, left atrial (LA) diameter, LA volume index, QRS duration, Tpe, and S-QRS score were statistically high in the deceased group. In multivariate logistic regression analysis, age, Hs-CRP, NT-proBNP, LA diameter, LA volume index, Tpe, and S-QRS score were shown to be independent risk factors for mortality. In the receiver-operating characteristic (ROC) analysis, the cut-off value of the S-QRS score was 5.5, the sensitivity was 80.8%, and the specificity was 77.2% (AUC:0.880, p:0.00). In Kaplan-Meier analysis, it was found that mortality was higher in the group with S-QRS score ≥ 5.5 than in the group with S-QRS score < 5.5. (Long-rank, p:0.00)

Conclusions  We think that the S-QRS score can be used as a prognostic indicator of long-term mortality in patients with HFpEF.

Selvester QRS; Mortality; Heart Failure; Myocardial Infarction; Electrocardiography/methods; Echocardiography/methods; Stroke Volume