Quercetin Ameliorates Lipid and Apolipoprotein Profile in High-Dose Glucocorticoid Treated Rats

Derakhshanian, Hoda; Djalali, Mahmoud; Djazayery, Abolghassem; Javanbakht, Mohammad Hassan; Zarei, Mahnaz; Hekmatdoost, Azita; Eslamian, Ghazaleh; Mirhashemi, Seyyedeh Somayyeh; Dehpour, Ahmad Reza

doi:10.36660/abc.20180397

Brasil

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Original Article • Arq. Bras. Cardiol. 115 (1) • July 2020 • https://doi.org/10.36660/abc.20180397 linkcopy

Quercetin Ameliorates Lipid and Apolipoprotein Profile in High-Dose Glucocorticoid Treated Rats

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Background Glucocorticoids (GCs) are widely prescribed for the treatment of numerous clinical disorders due to their anti-inflammatory and immune-modulatory properties and one of the most common untoward effects of these drugs is dyslipidemia.

Objective To evaluate the effect of quercetin, a plant-derived flavonoid, on the lipid profile of high-dose glucocorticoid treated rats.

Methods A total of 32 Sprague-Dawley rats, were randomly distributed among four groups (8 rats per group) and treated for 6 weeks with one of the following: (i) normal saline; (ii) 40 mg/kg methylprednisolone sodium succinate (MP); (iii) MP + 50 mg/kg quercetin; (iv) MP + 150 mg/kg quercetin. MP was injected subcutaneously, and quercetin was administered by oral gavage 3 days a week. At the end of the study, the animals’ lipid profile was measured by enzymatic kits. Data were analyzed and statistical significance was set at p<0.05.

Results The mean serum total cholesterol (TC), triglyceride (TG) and LDL levels were drastically increased in GC-treated animals compared with the control group. Both doses of quercetin (50 and 150 mg/kg) ameliorated TC (43% and 45%), LDL (56% and 56%) and TG (46% and 55% respectively). Apo B/A1 ratio decreased more than 20% following quercetin intake and the decline in TC/HDL, TG/HL, LDL/HDL ratios were significant.

Conclusions These data suggest that quercetin intake with both doses of 50 and 150 mg/kg could be considered as a protective agent for glucocorticoid-induced dyslipidemia. (Arq Bras Cardiol. 2020; 115(1):102-108.)

Rats, Sprague-Dawley; Anti-Inflammatory Agents; Quercetin; Glucocorticoids; Dyslipidemias; Triglycerides; Cholesterol

Body weight	Control	MP	MP+Q50	MP+Q150
Initial	212±29	212±27	210±28	212±28
Final	214±30^†	182±22^*,‡	185±20^*,‡	180±16^*,‡

	Control	MP	MP+Q50	MP+Q150	p value
TC (mg/dl)	89.12±3.35	193.50±12.77^*.‡	108.75±15.47^*.†	105.87±11.25^*.†	<0.001
HDL (mg/dl)	34.25±3.69	41.37±5.75^*	38.25±4.77	39.00±4.07	=0.03
LDL (mg/dl)	41.87±3.79	119.22±12.70^*.‡	52.72±15.15^†	52.22±10.87^†	<0.001
TG (mg/dl)	65.00±4.34	164.50±9.36^*.‡	88.87±12.93^*.†	73.25±11.33^†.‡	<0.001
TC/HDL	2.62±0.27	4.76±0.86^*.‡	2.86±0.42^†	2.74±0.47^†.‡	<0.001
TG/HDL	1.92±0.29	4.05±0.71^*.‡	2.33±0.34^†	1.92±0.51^†	<0.001
LDL/HDL	1.24±0.23	2.95±0.73^*.‡	1.39±0.43^†	1.36±0.38^†	<0.001
Apo B/ Al	0.93±0.16	1.63±0.19^*.‡	1.25±0.30^†	1.06±0.28^†	<0.001

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