TACTICS–TIMI 1414. Bach RG, Cannon CP, Weintraub WS, DiBattiste PM, Demopoulos LA, Anderson HV, et al. The Effect of Routine, Early Invasive Management on Outcome for Elderly Patients with Non-ST-Segment Elevation Acute Coronary Syndromes. Ann Intern Med. 2004;141(3):186-95. doi: 10.7326/0003-4819-141-3-200408030-00007.,1818. Hirlekar G, Libungan B, Karlsson T, Bäck M, Herlitz J, Albertsson P. Percutaneous Coronary Intervention in the Very Elderly with NSTE-ACS: The Randomized 80+ Study. Scand Cardiovasc J. 2020;54(5):315-21. doi: 10.1080/14017431.2020.1781243. 2004 |
RCT, multicenter |
139/139 |
cardiac death, MI or need for unplanned coronary revascularisation |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
6 months |
ACOS Registry,1919. Bauer T, Koeth O, Jünger C, Heer T, Wienbergen H, Gitt A, et al. Effect of an Invasive Strategy on In-Hospital Outcome in Elderly Patients with Non-ST-Elevation Myocardial Infarction. Eur Heart J. 2007;28(23):2873-8. doi: 10.1093/eurheartj/ehm464. 2007 |
prospective, multicenter, observational |
1005/931 |
death and MI |
78.7/82.2 |
51.7/41.4 |
79.2/74.8 |
62.3/49.7 |
33.5/39.4 |
NA |
NA |
4.5/9.2 |
NA |
NA |
12 months |
GRACE,2020. Devlin G, Gore JM, Elliott J, Wijesinghe N, Eagle KA, Avezum A, et al. Management and 6-Month Outcomes in Elderly and Very Elderly Patients with High-Risk Non-ST-Elevation Acute Coronary Syndromes: The Global Registry of Acute Coronary Events. Eur Heart J. 2008;29(10):1275-82. doi: 10.1093/eurheartj/ehn124. 2008 |
prospective, multicenter, observational |
620/2390 |
death, MI, and stroke |
85 |
48 |
73 |
39 |
26 |
NA |
27 |
11 |
NA |
15 |
6 months |
LOURENÇO,2121. Lourenço C, Teixeira R, Antonio N, Saraiva F, Baptista R, Jorge E, et al. Invasive Strategy in Non-ST Elevation Acute Coronary Syndromes: Risks and Benefits in an Elderly Population. Rev Port Cardiol. 2010;29(10):1451-72. 2010 |
prospective, single-center, observational |
91/216 |
death, cardiovascular death, MI, re-admission for unstable angina, and unscheduled PCI |
79.8/81.4 |
63.7/50.9 |
80.2/74.9 |
60.7/62.5 |
26.4/30.8 |
NA |
3.8/10.2 |
NA |
NA |
39.6/30.1 |
18 months |
FIR,1515. Damman P, Clayton T, Wallentin L, Lagerqvist B, Fox KA, Hirsch A, et al. Effects of Age on Long-Term Outcomes after a Routine Invasive or Selective Invasive Strategy in Patients Presenting with Non-ST Segment Elevation Acute Coronary Syndromes: A Collaborative Analysis of Individual Data from the FRISC II - ICTUS - RITA-3 (FIR) Trials. Heart. 2012;98(3):207-13. doi: 10.1136/heartjnl-2011-300453. 2012 |
RCT, multicenter |
437/402 |
cardiovascular death and MI |
76 |
63.5 |
39.0 |
15.7 |
14.8 |
NA |
NA |
NA |
NA |
NA |
5 years |
FAST-MI,2222. Puymirat E, Taldir G, Aissaoui N, Lemesle G, Lorgis L, Cuisset T, et al. Use of Invasive Strategy in Non-ST-Segment Elevation Myocardial Infarction is a Major Determinant of Improved Long-Term Survival: FAST-MI (French Registry of Acute Coronary Syndrome). JACC Cardiovasc Interv. 2012;5(9):893-902. doi: 10.1016/j.jcin.2012.05.008. 2012 |
prospective, multicenter, observational |
412/246 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
3 years |
Italian Elderly ACS,1616. Savonitto S, Cavallini C, Petronio AS, Murena E, Antonicelli R, Sacco A, et al. Early Aggressive versus Initially Conservative Treatment in Elderly Patients with Non-ST-Segment Elevation Acute Coronary Syndrome: A Randomized Controlled Trial. JACC Cardiovasc Interv. 2012;5(9):906-16. doi: 10.1016/j.jcin.2012.06.008. 2012 |
RCT, multicenter, |
154/159 |
all-cause mortality, MI, stroke, and repeat hospital stay |
81.8/81.8 |
49/51 |
92/85 |
44/50 |
38/41 |
49/48 |
10/8.9 |
NA |
71/78 |
17/6 |
1 year |
ACSIS,2323. Buber J, Goldenberg I, Kimron L, Guetta V. One-Year outcome Following Coronary Angiography in Elderly Patients with Non-ST Elevation Myocardial Infarction: Real-World Data from the Acute Coronary Syndromes Israeli Survey (ACSIS). Coron Artery Dis. 2013;24(2):102-9. doi: 10.1097/MCA.0b013e32835c8f53. 2013 |
prospective, multicenter, observational |
192/158 |
NA |
83 |
54 |
81 |
NA |
36 |
NA |
29 |
NA |
NA |
6 |
1 year |
PL-ACS,2424. Gierlotka M, Gąsior M, Tajstra M, Hawranek M, Osadnik T, Wilczek K, et al. Outcomes of Invasive Treatment in Very Elderly Polish Patients with Non-ST-Segment-Elevation Myocardial Infarction from 2003-2009 (from the PL-ACS registry). Cardiol J. 2013;20(1):34-43. doi: 10.5603/CJ.2013.0007. 2013 |
prospective, multicenter, observational |
3288/10419 |
NA |
82/83 |
47.5/37.2 |
78.6/71.0 |
36.3/32.6 |
30.9/30.5 |
NA |
NA |
NA |
NA |
4.6/0.1 |
2 years |
Kolte,2525. Kolte D, Khera S, Palaniswamy C, Mujib M, Fonarow GC, Ahmed A, et al. Early Invasive versus Initial Conservative Treatment Strategies in Octogenarians with UA/NSTEMI. Am J Med. 2013;126(12):1076-83.e1. doi: 10.1016/j.amjmed.2013.07.024. 2013 |
retrospective, multicenter, observational |
161640/ 806902 |
NA |
83.9/86.2 |
48.2/41 |
72/62.5 |
51.9/33.7 |
28.0/29.1 |
NA |
34.8/55 |
16.8/22.8 |
NA |
NA |
in-hospital |
MONICA/KORA MI,2626. Amann U, Kirchberger I, Heier M, von Scheidt W, Kuch B, Peters A, et al. Acute Myocardial Infarction in the Elderly: Treatment Strategies and 28-Day-Case Fatality from the MONICA/KORA Myocardial Infarction Registry. Catheter Cardiovasc Interv. 2016;87(4):680-8. doi: 10.1002/ccd.26159. 2016 |
prospective, multicenter, observational |
360/286 |
NA |
78/80 |
55.8/46/5 |
90.6/85.0 |
47.8/33.6 |
40.0/50.0 |
NA |
NA |
24.7/36.4 |
NA |
24.7/4.9 |
28 days |
Conti,2727. Conti E, Musumeci MB, Desideri JP, Ventura M, Fusco D, Zezza L, et al. Outcomes of Early Invasive Treatment Strategy in Elderly Patients with Non-ST Elevation Acute Coronary Syndromes. J Cardiovasc Med. 2016;17(10):736-43. doi: 10.2459/JCM.0000000000000364. 2016 |
prospective, single-center, observational |
301/152 |
death and MI |
80 |
52.8/34.2 |
91.7/90.8 |
53.5/38.8 |
41.2/42.1 |
NA |
NA |
NA |
NA |
NA |
1 year |
HUMIR,2828. Komócsi A, Simon M, Merkely B, Szűk T, Kiss RG, Aradi D, et al. Underuse of Coronary Intervention and its Impact on Mortality in the Elderly with Myocardial Infarction. A Propensity-Matched Analysis from the Hungarian Myocardial Infarction Registry. Int J Cardiol. 2016;214:485-90. doi: 10.1016/j.ijcard.2016.04.012. 2016 |
prospective, multicenter, observational |
654 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
1 year |
After Eighty study,1717. Tegn N, Abdelnoor M, Aaberge L, Endresen K, Smith P, Aakhus S, et al. Invasive versus Conservative Strategy in Patients Aged 80 Years or Older with Non-ST-Elevation Myocardial Infarction or Unstable Angina Pectoris (After Eighty study): An Open-Label Randomised Controlled Trial. Lancet. 2016;387(10023):1057-65. doi: 10.1016/S0140-6736(15)01166-6. 2016 |
RCT, multicenter |
229/228 |
MI, need for urgent revascularisation, stroke, and death |
84.7/84.9 |
55/44 |
57/61 |
NA |
20/14 |
NA |
NA |
NA |
90 |
NA |
3 years |
AMI-OPTIMA,4040. Couture EL, Farand P, Nguyen M, Allard C, Wells GA, Mansour S, et al. Impact of an Invasive Strategy in the Elderly Hospitalized with Acute Coronary Syndrome with Emphasis on the Nonagenarians. Catheter Cardiovasc Interv. 2018;92(7):E441-E448. doi: 10.1002/ccd.27877. 2018 |
sub-analysis of RCT, multicenter |
548/610 |
NA |
85.6 |
47.6 |
78.3 |
53.4 |
31.2 |
NA |
NA |
25.3 |
NA |
NA |
in-hospital |
Liu,2929. Liu SL, Wu NQ, Zhang M, Jin JL, Zhou BY, Dong Q, et al. Association of Invasive Treatment and Lower Mortality of Patients ≥ 80 Years with Acute Myocardial Infarction: A Propensity-Matched Analysis. J Geriatr Cardiol. 2018;15(11):666-74. doi: 10.11909/j.issn.1671-5411.2018.11.009. 2018 |
retrospective, single-center, observational |
319 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
32,3 months |
LONGEVO-SCA,3030. Llaó I, Ariza-Solé A, Sanchis J, Alegre O, López-Palop R, Formiga F, et al. Invasive Strategy and Frailty in Very Elderly Patients with Acute Coronary Syndromes. EuroIntervention. 2018;14(3):e336-e342. doi: 10.4244/EIJ-D-18-00099. 2018 |
prospective, multicenter, observational |
407/124 |
cardiac death, MI, or need for unplanned coronary revascularization |
83.6/86.7 |
64.7/50.0 |
84.0/87.1 |
NA |
39.0/42.7 |
53.2/53.7 |
14.3/29.0 |
NA |
84.5 |
NA |
6 months |
SWEDEHEART,3131. Reinius P, Mellbin L, Holzmann MJ, Siddiqui AJ. Percutaneous Coronary Intervention versus Conservative Treatment for non ST-Segment Elevation Myocardial Infarction in Patients Above 80 Years of Age. Int J Cardiol. 2018;267:57-61. doi: 10.1016/j.ijcard.2018.05.078. 2018 |
prospective, multicenter, observational |
4158/9696 |
NA |
84/86 |
57/46 |
63/63 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
5 years |
Kvakkestad,3232. Kvakkestad KM, Gran JM, Eritsland J, Holst Hansen C, Fossum E, Andersen GØ, et al. Long-Term Survival after Invasive or Conservative Strategy in Elderly Patients with Non-ST-Elevation Myocardial Infarction: A Prospective Cohort Study. Cardiology. 2019;144(3-4):79-89. doi: 10.1159/000503442. 2019 |
prospective, single center, observational |
1200/864 |
NA |
80.4/86.4 |
60.6/39.7 |
50.1/48.4 |
NA |
20.7/19.0 |
NA |
NA |
NA |
NA |
NA |
7 years |
CAMI,3333. Leng W, Yang J, Fan X, Sun Y, Xu H, Gao X, et al. Contemporary Invasive Management and In-Hospital Outcomes of Patients with Non-ST-Segment Elevation Myocardial Infarction in China: Findings from China Acute Myocardial Infarction (CAMI) Registry. Am Heart J. 2019;215:1-11. doi: 10.1016/j.ahj.2019.05.015. 2019 |
prospective, multicenter, observational |
551/1900 |
all-cause death, MI, and stroke |
80.37 |
54.6 |
65.8 |
6.0 |
25.0 |
53.41 |
10.8 |
NA |
NA |
10.8 |
in-hospital |
Sui,3434. Sui YG, Teng SY, Qian J, Wu Y, Dou KF, Tang YD, et al. A Retrospective Study of an Invasive versus Conservative Strategy in Patients Aged ≥80 Years with Acute ST-Segment Elevation Myocardial Infarction. J Int Med Res. 2019;47(9):4431-41. doi: 10.1177/0300060519860969. 2019 |
retrospective, single-center, observational |
139/93 |
NA |
83.4/84.8 |
52.5/57.0 |
66.9/68.8 |
93.5/90.3 |
40.3/34.4 |
51.9/45.3 |
NA |
23.7/36.6 |
NA |
NA |
4 years |
Gonçalves,3535. Gonçalves FF, Guimarães JP, Borges SC, Mateus PS, Moreira JI. Impact of Coronary Angioplasty in Elderly Patients with Non-ST-Segment Elevation Myocardial Infarction. J Geriatr Cardiol. 2020;17(8):449-454. doi: 10.11909/j.issn.1671-5411.2020.08.001.2020 |
retrospective, multicenter, observational |
237/87 |
NA |
87/87 |
54.0/60.9 |
86.4/90.7 |
58.8/59.5 |
29.6/43.7 |
52/49 |
NA |
14.1/9.4 |
64.5/80.7 |
NA |
1 year |
Hirlekar,1818. Hirlekar G, Libungan B, Karlsson T, Bäck M, Herlitz J, Albertsson P. Percutaneous Coronary Intervention in the Very Elderly with NSTE-ACS: The Randomized 80+ Study. Scand Cardiovasc J. 2020;54(5):315-21. doi: 10.1080/14017431.2020.1781243. 2020 |
RCT, multicenter |
93/93 |
MI, urgent revascularization, all-cause mortality, stroke, and recurrent hospitalization |
84/84 |
50.5/59.1 |
59.1/63.4 |
22.6/17.2 |
17.2/21.5 |
55/54 |
10.8/8.6 |
63.4/75.3 |
NA |
NA |
1 year |
SENIOR-NSTEMI,3636. Kaura A, Sterne JAC, Trickey A, Abbott S, Mulla A, Glampson B, et al. Invasive versus Non-Invasive Management of Older Patients with Non-ST Elevation Myocardial Infarction (SENIOR-NSTEMI): A Cohort Study Based on Routine Clinical Data. Lancet. 2020;396(10251):623-34. doi: 10.1016/S0140-6736(20)30930-2. 2020 |
prospective, multicenter, observational |
655/845 |
NA |
85.3/86.9 |
60/50 |
62/54 |
42/30 |
26/24 |
NA |
17/24 |
7/8 |
NA |
NA |
4,8 years |
Nguyen,3737. Nguyen TV, Bui KX, Tran KD, Le D, Nguyen TN. Non-ST Elevation Acute Coronary Syndrome in Patients Aged 80 Years or Older in Vietnam: An Observational Study. PLoS One. 2020;15(6):e0233272. doi: 10.1371/journal.pone.0233272. 2020 |
prospective, multicenter, observational |
42/78 |
all-cause mortality, MI, stroke |
84.1/85.2 |
59.5/44.9 |
97.6/85.9 |
NA |
21.4/23.1 |
NA |
21.4/48.7 |
NA |
NA |
NA |
3 months |
Phan,3838. Phan DQ, Rostomian AH, Schweis F, Chung J, Lin B, Zadegan R, et al. Revascularization versus Medical Therapy in Patients Aged 80 Years and Older with Acute Myocardial Infarction. J Am Geriatr Soc. 2020;68(11):2525-33. doi: 10.1111/jgs.16747. 2020 |
retrospective, single-center, observational |
890/543 |
NA |
83.3/83.3 |
64.6/67.4 |
91.9/94.1 |
93.0/93.6 |
49.1/56.9 |
51/45 |
44.5/64.8 |
58.1/63.9 |
NA |
NA |
2,6 years |
Kunniardy,3939. Kunniardy P, Koshy AN, Meehan G, Murphy AC, Ramchand J, Clark DJ, et al. Invasive versus Conservative Management in Patients Aged ≥85 Years Presenting with Non-ST-Elevation Myocardial Infarction. Intern Med J. 2022;52(7):1167-73. doi: 10.1111/imj.15258. 2021 |
retrospective, single- center, observational |
99/953 |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
1,3 years |