TÁTICAS–TIMI 1414. Bach RG, Cannon CP, Weintraub WS, DiBattiste PM, Demopoulos LA, Anderson HV, et al. The Effect of Routine, Early Invasive Management on Outcome for Elderly Patients with Non-ST-Segment Elevation Acute Coronary Syndromes. Ann Intern Med. 2004;141(3):186-95. doi: 10.7326/0003-4819-141-3-200408030-00007.,1818. Hirlekar G, Libungan B, Karlsson T, Bäck M, Herlitz J, Albertsson P. Percutaneous Coronary Intervention in the Very Elderly with NSTE-ACS: The Randomized 80+ Study. Scand Cardiovasc J. 2020;54(5):315-21. doi: 10.1080/14017431.2020.1781243. 2004 |
ECR, multicêntrico |
139/139 |
Morte cardíaca, IM ou necessidade de revascularização coronária não planejada |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
6 meses |
Registro ACOS1919. Bauer T, Koeth O, Jünger C, Heer T, Wienbergen H, Gitt A, et al. Effect of an Invasive Strategy on In-Hospital Outcome in Elderly Patients with Non-ST-Elevation Myocardial Infarction. Eur Heart J. 2007;28(23):2873-8. doi: 10.1093/eurheartj/ehm464. 2007 |
Prospectivo, multicêntrico, observacional |
1005/931 |
Morte e IM |
78,7/82,2 |
51,7/41,4 |
79,2/74,8 |
62,3/49,7 |
33,5/39,4 |
N / D |
N / D |
4.5/9.2 |
N / D |
N / D |
12 meses |
GRACE, 2020. Devlin G, Gore JM, Elliott J, Wijesinghe N, Eagle KA, Avezum A, et al. Management and 6-Month Outcomes in Elderly and Very Elderly Patients with High-Risk Non-ST-Elevation Acute Coronary Syndromes: The Global Registry of Acute Coronary Events. Eur Heart J. 2008;29(10):1275-82. doi: 10.1093/eurheartj/ehn124. 2008 |
Prospectivo, multicêntrico, observacional |
620/2390 |
Morte, IM e AVC |
85 |
48 |
73 |
39 |
26 |
N / D |
27 |
11 |
N / D |
15 |
6 meses |
LOURENÇO,2121. Lourenço C, Teixeira R, Antonio N, Saraiva F, Baptista R, Jorge E, et al. Invasive Strategy in Non-ST Elevation Acute Coronary Syndromes: Risks and Benefits in an Elderly Population. Rev Port Cardiol. 2010;29(10):1451-72. 2010 |
Prospectivo, de centro único, observacional |
91/216 |
Morte, morte cardiovascular, infarto do miocárdio, readmissão por angina instável e ICP não programada |
79,8/81,4 |
63,7/50,9 |
80,2/74,9 |
60,7/62,5 |
26,4/30,8 |
N / D |
3,8/10,2 |
N / D |
N / D |
39,6/30,1 |
18 meses |
FIR,1515. Damman P, Clayton T, Wallentin L, Lagerqvist B, Fox KA, Hirsch A, et al. Effects of Age on Long-Term Outcomes after a Routine Invasive or Selective Invasive Strategy in Patients Presenting with Non-ST Segment Elevation Acute Coronary Syndromes: A Collaborative Analysis of Individual Data from the FRISC II - ICTUS - RITA-3 (FIR) Trials. Heart. 2012;98(3):207-13. doi: 10.1136/heartjnl-2011-300453. 2012 |
ECR, multicêntrico |
437/402 |
IM e infarto do miocárdio |
76 |
63,5 |
39,0 |
15.7 |
14.8 |
N / D |
N / D |
N / D |
N / D |
N / D |
5 anos |
FAST-MI,2222. Puymirat E, Taldir G, Aissaoui N, Lemesle G, Lorgis L, Cuisset T, et al. Use of Invasive Strategy in Non-ST-Segment Elevation Myocardial Infarction is a Major Determinant of Improved Long-Term Survival: FAST-MI (French Registry of Acute Coronary Syndrome). JACC Cardiovasc Interv. 2012;5(9):893-902. doi: 10.1016/j.jcin.2012.05.008. 2012 |
Prospectivo, multicêntrico, observacional |
412/246 |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
3 anos |
Italian Elderly ACS,1616. Savonitto S, Cavallini C, Petronio AS, Murena E, Antonicelli R, Sacco A, et al. Early Aggressive versus Initially Conservative Treatment in Elderly Patients with Non-ST-Segment Elevation Acute Coronary Syndrome: A Randomized Controlled Trial. JACC Cardiovasc Interv. 2012;5(9):906-16. doi: 10.1016/j.jcin.2012.06.008. 2012 |
ECR, multicêntrico, |
154/159 |
Morte por todas as causas, IM, AVC, e repetir internação |
81,8/81,8 |
49/51 |
92/85 |
44/50 |
38/41 |
49/48 |
10/8.9 |
N / D |
71/78 |
17/6 |
1 ano |
ACSIS,2323. Buber J, Goldenberg I, Kimron L, Guetta V. One-Year outcome Following Coronary Angiography in Elderly Patients with Non-ST Elevation Myocardial Infarction: Real-World Data from the Acute Coronary Syndromes Israeli Survey (ACSIS). Coron Artery Dis. 2013;24(2):102-9. doi: 10.1097/MCA.0b013e32835c8f53. 2013 |
Prospectivo, multicêntrico, observacional |
192/158 |
N / D |
83 |
54 |
81 |
N / D |
36 |
N / D |
29 |
N / D |
N / D |
6 |
1 ano |
PL-ACS,2424. Gierlotka M, Gąsior M, Tajstra M, Hawranek M, Osadnik T, Wilczek K, et al. Outcomes of Invasive Treatment in Very Elderly Polish Patients with Non-ST-Segment-Elevation Myocardial Infarction from 2003-2009 (from the PL-ACS registry). Cardiol J. 2013;20(1):34-43. doi: 10.5603/CJ.2013.0007.2013 |
Prospectivo, multicêntrico, observacional |
3288/10419 |
N / D |
82/83 |
47,5/37,2 |
78,6/71,0 |
36,3/32,6 |
30,9/30,5 |
N / D |
N / D |
N / D |
N / D |
4,6/0,1 |
2 anos |
Kolte,2525. Kolte D, Khera S, Palaniswamy C, Mujib M, Fonarow GC, Ahmed A, et al. Early Invasive versus Initial Conservative Treatment Strategies in Octogenarians with UA/NSTEMI. Am J Med. 2013;126(12):1076-83.e1. doi: 10.1016/j.amjmed.2013.07.024. 2013 |
Retrospectivo, multicêntrico, observacional |
161640/ 806902 |
N / D |
83,9/86,2 |
48.2/41 |
72/62,5 |
51,9/33,7 |
28.0/29.1 |
N / D |
34,8/55 |
16,8/22,8 |
N / D |
N / D |
Hospitalização |
MONICA/KORA MI,2626. Amann U, Kirchberger I, Heier M, von Scheidt W, Kuch B, Peters A, et al. Acute Myocardial Infarction in the Elderly: Treatment Strategies and 28-Day-Case Fatality from the MONICA/KORA Myocardial Infarction Registry. Catheter Cardiovasc Interv. 2016;87(4):680-8. doi: 10.1002/ccd.26159. 2016 |
Prospectivo, multicêntrico, observacional |
360/286 |
N / D |
78/80 |
55,8/46/5 |
90,6/85,0 |
47,8/33,6 |
40,0/50,0 |
N / D |
N / D |
24,7/36,4 |
N / D |
24,7/4,9 |
28 dias |
Conti,2727. Conti E, Musumeci MB, Desideri JP, Ventura M, Fusco D, Zezza L, et al. Outcomes of Early Invasive Treatment Strategy in Elderly Patients with Non-ST Elevation Acute Coronary Syndromes. J Cardiovasc Med. 2016;17(10):736-43. doi: 10.2459/JCM.0000000000000364. 2016 |
Prospectivo, de centro único, observacional |
301/152 |
Morte e IM |
80 |
52,8/34,2 |
91,7/90,8 |
53,5/38,8 |
41.2/42.1 |
N / D |
N / D |
N / D |
N / D |
N / D |
1 ano |
HUMIR,2828. Komócsi A, Simon M, Merkely B, Szűk T, Kiss RG, Aradi D, et al. Underuse of Coronary Intervention and its Impact on Mortality in the Elderly with Myocardial Infarction. A Propensity-Matched Analysis from the Hungarian Myocardial Infarction Registry. Int J Cardiol. 2016;214:485-90. doi: 10.1016/j.ijcard.2016.04.012.2016 |
Prospectivo, multicêntrico, observacional |
654 |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
1 ano |
Estudo After Eighty, 1717. Tegn N, Abdelnoor M, Aaberge L, Endresen K, Smith P, Aakhus S, et al. Invasive versus Conservative Strategy in Patients Aged 80 Years or Older with Non-ST-Elevation Myocardial Infarction or Unstable Angina Pectoris (After Eighty study): An Open-Label Randomised Controlled Trial. Lancet. 2016;387(10023):1057-65. doi: 10.1016/S0140-6736(15)01166-6. 2016 |
ECR, multicêntrico |
229/228 |
IM, necessidade de revascularização urgente, AVC e morte |
84,7/84,9 |
55/44 |
57/61 |
N / D |
20/14 |
N / D |
N / D |
N / D |
90 |
N / D |
3 anos |
AMI-OPTIMA,4040. Couture EL, Farand P, Nguyen M, Allard C, Wells GA, Mansour S, et al. Impact of an Invasive Strategy in the Elderly Hospitalized with Acute Coronary Syndrome with Emphasis on the Nonagenarians. Catheter Cardiovasc Interv. 2018;92(7):E441-E448. doi: 10.1002/ccd.27877. 2018 |
Subanálise de ECR, multicêntrico |
548/610 |
N / D |
85,6 |
47,6 |
78,3 |
53.4 |
31.2 |
N / D |
N / D |
25.3 |
N / D |
N / D |
no Hospital |
Liu,2929. Liu SL, Wu NQ, Zhang M, Jin JL, Zhou BY, Dong Q, et al. Association of Invasive Treatment and Lower Mortality of Patients ≥ 80 Years with Acute Myocardial Infarction: A Propensity-Matched Analysis. J Geriatr Cardiol. 2018;15(11):666-74. doi: 10.11909/j.issn.1671-5411.2018.11.009. 2018 |
Retrospectivo, de centro único, observacional |
319 |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
32,3 meses |
LONGEVO-SCA,3030. Llaó I, Ariza-Solé A, Sanchis J, Alegre O, López-Palop R, Formiga F, et al. Invasive Strategy and Frailty in Very Elderly Patients with Acute Coronary Syndromes. EuroIntervention. 2018;14(3):e336-e342. doi: 10.4244/EIJ-D-18-00099. 2018 |
Prospectivo, multicêntrico, observacional |
407/124 |
Morte cardíaca, IM ou necessidade de revascularização coronária não planejada |
83,6/86,7 |
64,7/50,0 |
84.0/87.1 |
N / D |
39,0/42,7 |
53,2/53,7 |
14,3/29,0 |
N / D |
84,5 |
N / D |
6 meses |
SWEDE HEART, 3131. Reinius P, Mellbin L, Holzmann MJ, Siddiqui AJ. Percutaneous Coronary Intervention versus Conservative Treatment for non ST-Segment Elevation Myocardial Infarction in Patients Above 80 Years of Age. Int J Cardiol. 2018;267:57-61. doi: 10.1016/j.ijcard.2018.05.078. 2018 |
Prospectivo, multicêntrico, observacional |
4158/9696 |
N / D |
84/86 |
57/46 |
63/63 |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
5 anos |
Kvakkestad,3232. Kvakkestad KM, Gran JM, Eritsland J, Holst Hansen C, Fossum E, Andersen GØ, et al. Long-Term Survival after Invasive or Conservative Strategy in Elderly Patients with Non-ST-Elevation Myocardial Infarction: A Prospective Cohort Study. Cardiology. 2019;144(3-4):79-89. doi: 10.1159/000503442. 2019 |
Prospectivo, centro único, observacional |
1200/864 |
N / D |
80,4/86,4 |
60,6/39,7 |
50,1/48,4 |
N / D |
20,7/19,0 |
N / D |
N / D |
N / D |
N / D |
N / D |
7 anos |
CAMI,3333. Leng W, Yang J, Fan X, Sun Y, Xu H, Gao X, et al. Contemporary Invasive Management and In-Hospital Outcomes of Patients with Non-ST-Segment Elevation Myocardial Infarction in China: Findings from China Acute Myocardial Infarction (CAMI) Registry. Am Heart J. 2019;215:1-11. doi: 10.1016/j.ahj.2019.05.015. 2019 |
Prospectivo, multicêntrico, observacional |
551/1900 |
Morte por todas as causas, IM e AVC |
80,37 |
54,6 |
65,8 |
6.0 |
25,0 |
53,41 |
10.8 |
N / D |
N / D |
10.8 |
No Hospital |
Sui,3434. Sui YG, Teng SY, Qian J, Wu Y, Dou KF, Tang YD, et al. A Retrospective Study of an Invasive versus Conservative Strategy in Patients Aged ≥80 Years with Acute ST-Segment Elevation Myocardial Infarction. J Int Med Res. 2019;47(9):4431-41. doi: 10.1177/0300060519860969. 2019 |
Retrospectivo, de centro único, observacional |
139/93 |
N / D |
83,4/84,8 |
52,5/57,0 |
66,9/68,8 |
93,5/90,3 |
40,3/34,4 |
51,9/45,3 |
N / D |
23,7/36,6 |
N / D |
N / D |
4 anos |
Gonçalves,3535. Gonçalves FF, Guimarães JP, Borges SC, Mateus PS, Moreira JI. Impact of Coronary Angioplasty in Elderly Patients with Non-ST-Segment Elevation Myocardial Infarction. J Geriatr Cardiol. 2020;17(8):449-454. doi: 10.11909/j.issn.1671-5411.2020.08.001. 2020 |
Retrospectivo, multicêntrico, observacional |
237/87 |
N / D |
87/87 |
54,0/60,9 |
86,4/90,7 |
58,8/59,5 |
29,6/43,7 |
52/49 |
N / D |
14.1/9.4 |
64,5/80,7 |
N / D |
1 ano |
Hirlekar,1818. Hirlekar G, Libungan B, Karlsson T, Bäck M, Herlitz J, Albertsson P. Percutaneous Coronary Intervention in the Very Elderly with NSTE-ACS: The Randomized 80+ Study. Scand Cardiovasc J. 2020;54(5):315-21. doi: 10.1080/14017431.2020.1781243.2020 |
ECR, multicêntrico |
93/93 |
IM, revascularização urgente, mortalidade por todas as causas, AVC e hospitalização recorrente |
84/84 |
50,5/59,1 |
59,1/63,4 |
22,6/17,2 |
17,2/21,5 |
55/54 |
10,8/8,6 |
63,4/75,3 |
N / D |
N / D |
1 ano |
SENIOR-NSTEMI,3636. Kaura A, Sterne JAC, Trickey A, Abbott S, Mulla A, Glampson B, et al. Invasive versus Non-Invasive Management of Older Patients with Non-ST Elevation Myocardial Infarction (SENIOR-NSTEMI): A Cohort Study Based on Routine Clinical Data. Lancet. 2020;396(10251):623-34. doi: 10.1016/S0140-6736(20)30930-2. 2020 |
Prospectivo, multicêntrico, observacional |
655/845 |
N / D |
85,3/86,9 |
60/50 |
62/54 |
42/30 |
26/24 |
N / D |
17/24 |
7/8 |
N / D |
N / D |
4,8 anos |
Nguyen,3737. Nguyen TV, Bui KX, Tran KD, Le D, Nguyen TN. Non-ST Elevation Acute Coronary Syndrome in Patients Aged 80 Years or Older in Vietnam: An Observational Study. PLoS One. 2020;15(6):e0233272. doi: 10.1371/journal.pone.0233272.2020 |
Prospectivo, multicêntrico, observacional |
42/78 |
Mortalidade por todas as causas, IM e AVC |
84.1/85.2 |
59,5/44,9 |
97,6/85,9 |
N / D |
21.4/23.1 |
N / D |
21,4/48,7 |
N / D |
N / D |
N / D |
3 meses |
Phan,3838. Phan DQ, Rostomian AH, Schweis F, Chung J, Lin B, Zadegan R, et al. Revascularization versus Medical Therapy in Patients Aged 80 Years and Older with Acute Myocardial Infarction. J Am Geriatr Soc. 2020;68(11):2525-33. doi: 10.1111/jgs.16747. 2020 |
Retrospectivo, de centro único, observacional |
890/543 |
N / D |
83,3/83,3 |
64,6/67,4 |
91.9/94.1 |
93,0/93,6 |
49,1/56,9 |
51/45 |
44,5/64,8 |
58,1/63,9 |
N / D |
N / D |
2,6 anos |
Kunniardy,3939. Kunniardy P, Koshy AN, Meehan G, Murphy AC, Ramchand J, Clark DJ, et al. Invasive versus Conservative Management in Patients Aged ≥85 Years Presenting with Non-ST-Elevation Myocardial Infarction. Intern Med J. 2022;52(7):1167-73. doi: 10.1111/imj.15258. 2021 |
Retrospectivo, de centro único, observacional |
99/953 |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
N / D |
1,3 anos |