Primeiro Autor |
País (Etnia) |
Caso |
Controle |
Casos |
Controles |
MAFs |
HWE |
Genotipos |
Alelo |
Genotipos |
Alelo |
|
|
|
|
|
|
AA |
CA |
CC |
A |
C |
AA |
CA |
CC |
A |
C |
|
|
Wu 2003 4646 Wu MS, Wu CY, Chen CJ, Lin MT, Shun CT, Lin JT. Interleukin-10 genotypes associate with the risk of gastric carcinoma in Taiwanese Chinese. Int J cancer. 2003;104(5):617-623. doi:10.1002/ijc.10987. https://doi.org/10.1002/ijc.10987...
|
China (asiáticos) |
220 |
230 |
88 |
105 |
27 |
281 |
159 |
127 |
83 |
20 |
337 |
123 |
0,267 |
0,231 |
El-Omar 2003 1010 El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB, et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology. 2003;124(5):1193-1201.
|
EUA (caucasiano) |
314 |
210 |
35 |
101 |
178 |
171 |
457 |
13 |
70 |
127 |
96 |
324 |
0,771 |
=0,001 |
Savage 2004 3737 Savage SA, Abnet CC, Haque K, Mark SD, Qiao YL, Dong ZW, et al. Polymorphisms in interleukin -2, -6, and -10 are not associated with gastric cardia or esophageal cancer in a high-risk Chinese population. Cancer Epidemiol Biomarkers Prev. 2004;13(9):1547-1549.
|
China (asiáticos) |
84 |
386 |
9 |
39 |
36 |
57 |
111 |
49 |
166 |
171 |
205 |
567 |
0,734 |
0,382 |
Zambon 2005 5353 Zambon CF, Basso D, Navaglia F, Belluco C, Falda A, Fogar P, et al. Pro- and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome. Cytokine. 2005;29(4):141-152. doi:10.1016/j.cyto.2004.10.013. https://doi.org/10.1016/j.cyto.2004.10.0...
|
Itália (caucasiano) |
129 |
644 |
17 |
42 |
70 |
76 |
182 |
46 |
245 |
353 |
337 |
951 |
0,738 |
0,696 |
Alpizar-Alpizar 2005 11 Alpízar-Alpízar W, Pérez-Pérez GI, Une C, Cuenca P, Sierra R. Association of interleukin-1B and interleukin-1RN polymorphisms with gastric cancer in a high-risk population of Costa Rica. Clin Exp Med. 2005;5(4):169-176. doi:10.1007/s10238-005-0082-3. https://doi.org/10.1007/s10238-005-0082-...
|
Costa Rica (latinos) |
45 |
45 |
3 |
20 |
21 |
27 |
63 |
5 |
21 |
18 |
32 |
58 |
0,647 |
0,761 |
Lee 2005 2525 Lee JY, Kim HY, Kim KH, Kim SM, Jang MK, Park JY, et al. Association of polymorphism of IL-10 and TNF-A genes with gastric cancer in Korea. Cancer Lett. 2005;225(2):207-214. doi:10.1016/j.canlet.2004.11.028. https://doi.org/10.1016/j.canlet.2004.11...
|
Coreia (asiáticos) |
122 |
120 |
52 |
62 |
8 |
166 |
78 |
53 |
60 |
7 |
166 |
74 |
0,308 |
0,059 |
Kamangar 2006 1919 Kamangar F, Abnet CC, Hutchinson AA, Newschaffer CJ, Helzlsouer K, Shugart YY, et al. Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland). Cancer Causes Control. 2006;17(1):117-125. doi:10.1007/s10552-005-0439-7. https://doi.org/10.1007/s10552-005-0439-...
|
Finlândia (caucasiano) |
112 |
237 |
6 |
38 |
68 |
50 |
174 |
17 |
82 |
109 |
132 |
342 |
0,721 |
0,775 |
Sicinschi 2006 3939 Sicinschi LA, Lopez-Carrillo L, Camargo MC, Correa P, Sierra RA, Henry RR, et al. Gastric cancer risk in a Mexican population: role of Helicobacter pylori CagA positive infection and polymorphisms in interleukin-1 and -10 genes. Int J cancer. 2006;118(3):649-657. doi:10.1002/ijc.21364. https://doi.org/10.1002/ijc.21364...
|
México (latinos) |
181 |
369 |
40 |
90 |
51 |
170 |
192 |
95 |
176 |
98 |
366 |
372 |
0,504 |
0,376 |
Sugimoto 2007 4343 Sugimoto M, Furuta T, Shirai N, Nakamura A, Kajimura M, Sugimura H, et al. Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects. J Gastroenterol Hepatol. 2007;22(9):1443-1449. doi:10.1111/j.1440-1746.2006.04613.x https://doi.org/10.1111/j.1440-1746.2006...
|
Japão (asiático) |
105 |
168 |
43 |
54 |
8 |
140 |
70 |
88 |
70 |
10 |
246 |
90 |
0,267 |
0,419 |
Garcia 2008 1111 García-González MA, Lanas A, Quintero E, Nicolás D, Parra-Blanco A, Strunk M, Benito R, et al. Gastric Cancer Susceptibility Is Not Linked to Pro-and Anti-Inflammatory Cytokine Gene Polymorphisms in Whites: A Nationwide Multicenter Study in Spain. Am J Gastroenterol. 2007;102(9):1878-1892. doi:10.1111/j.1572-0241.2007.01423.x https://doi.org/10.1111/j.1572-0241.2007...
|
Espanha (caucasiano) |
404 |
404 |
24 |
143 |
237 |
191 |
617 |
28 |
131 |
245 |
187 |
621 |
0,768 |
0,075 |
Crusius 2008 55 Crusius JB1, Canzian F, Capellá G, Peña AS, Pera G, Sala N, et al. Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). Ann Oncol. 2008;19(11):1894-1902. doi:10.1093/annonc/mdn400. https://doi.org/10.1093/annonc/mdn400...
|
Holanda (caucasiano) |
237 |
1122 |
11 |
78 |
148 |
100 |
374 |
83 |
397 |
642 |
563 |
1681 |
0,749 |
0,049 |
Deng 2008 88 Deng W, He L, Peng X. [The relationship among IL-10 gene polymorphisms H elicobacter pylori and noncardia gastric cancer development in Fujian province]. [Article in Chinese]. Wei Chang Bing Xue He Gan Bing Xue Za Zhi. 2008;17:212-214.
|
China (asiáticos) |
125 |
110 |
30 |
39 |
56 |
99 |
151 |
39 |
25 |
46 |
103 |
117 |
0,531 |
=0,001 |
Xiao 2009 4747 Xiao H, Jiang Y, Li R, Xia B. [Association of IL-10 gene polymorphisms with gastroduodenal diseases in Hubei Han population]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009;26(4):423-426.
|
China (asiáticos) |
220 |
624 |
100 |
100 |
20 |
300 |
140 |
272 |
283 |
69 |
1038 |
210 |
0,337 |
0,718 |
Kang 2009 2020 Kang JM, Kim N, Lee DH, Park JH, Lee MK, Kim JS, et al. The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea. J Clin Gastroenterol. 2009;43(5):420-428. doi:10.1097/MCG.0b013e318178d1d3. https://doi.org/10.1097/MCG.0b013e318178...
|
Coreia (asiáticos) |
333 |
332 |
142 |
157 |
34 |
441 |
225 |
146 |
145 |
41 |
437 |
227 |
0,341 |
0,591 |
Con 2009 33 Con SA, Takeuchi H, Con-Chin GR, Con-Chin VG, Yasuda N, Con-Wong R. Role of bacterial and genetic factors in gastric cancer in Costa Rica. World J Gastroenterol. 2009;15(2):211-218. doi:10.3748/WJG.15.211. https://doi.org/10.3748/WJG.15.211...
|
Costa Rica (latinos) |
52 |
191 |
10 |
26 |
16 |
44 |
60 |
23 |
65 |
103 |
111 |
271 |
0,709 |
0,015 |
Oh 2010 3333 Oh SS, Chang SC, Cai L, Cordon-Cardo C, Ding BG, Greenland S, et al. Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers. Int J cancer. 2010;127(9):2169-2182. doi:10.1002/ijc.25214. https://doi.org/10.1002/ijc.25214...
|
China (asiáticos) |
178 |
362 |
77 |
81 |
20 |
235 |
121 |
167 |
159 |
36 |
493 |
231 |
0,319 |
0,861 |
Liu 2011 2727 Liu J, Song B, Wang J-L, Li Z-J, Li W-H, Wang Z-H. Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer. World J Gastroenterol. 2011;17(10):1362. doi:10.3748/wjg.v17.i10.1362. https://doi.org/10.3748/wjg.v17.i10.1362...
|
China (asiáticos) |
234 |
243 |
99 |
96 |
39 |
294 |
174 |
109 |
106 |
28 |
324 |
162 |
0,333 |
0,772 |
He 2012 1414 He B, Pan Y, Xu Y, Nie Z, Chen L, Gu L, et al. Increased Risk for Gastric Cancer in Carriers of the Lymphotoxin-a+252G Variant Infected by Helicobacter pylori. Genet Test Mol Biomarkers. 2012;16(1):9-14. doi:10.1089/gtmb.2011.0078. https://doi.org/10.1089/gtmb.2011.0078...
|
China (asiáticos) |
196 |
248 |
82 |
96 |
18 |
260 |
132 |
92 |
128 |
28 |
312 |
184 |
0,371 |
0,095 |
Zeng 2012 5454 Zeng X, Li Y, Liu T, Zhang J. Diverse H. pylori strains, IL-10 promoter polymorphisms with high morbidity of gastric cancer in Hexi area of Gansu Province, China. Mol Cell Biochem. 2012;362(1-2):241-248. doi:10.1007/s11010-011-1149-y. https://doi.org/10.1007/s11010-011-1149-...
|
China (asiáticos) |
151 |
153 |
59 |
77 |
15 |
195 |
107 |
80 |
66 |
7 |
226 |
80 |
0,261 |
0,147 |
Kim 2012 2222 Kim J, Cho YA, Choi IJ, Lee YS, Kim SY, Shin A, et al. Effects of interleukin-10 polymorphisms, Helicobacter pylori infection, and smoking on the risk of noncardia gastric cancer. Katoh M, ed. PLoS One. 2012;7(1):e29643. doi:10.1371/journal.pone.0029643. https://doi.org/10.1371/journal.pone.002...
|
Coreia (asiáticos) |
495 |
495 |
231 |
214 |
50 |
676 |
314 |
248 |
191 |
56 |
687 |
303 |
0,306 |
0,041 |
Pan 2013 3434 Pan XF, Yang SJ, Loh M, Xie Y, Wen YY, Tian Z, et al. Interleukin-10 gene promoter polymorphisms and risk of gastric cancer in a Chinese population: single nucleotide and haplotype analyses. Asian Pac J Cancer Prev. 2013;14(4):2577-2582.
|
China (asiáticos) |
308 |
308 |
144 |
128 |
36 |
416 |
200 |
142 |
135 |
31 |
419 |
197 |
0,319 |
0,895 |
Kuo 2014 2424 Kuo WH, Huang CY, Fu CK, Hsieh YH, Liao CH, Hsu CM,et al. Effects of interleukin-10 polymorphisms and smoking on the risk of gastric cancer in Taiwan. In Vivo. 2014;28(5):967-971.
|
China (asiáticos) |
358 |
358 |
186 |
134 |
38 |
506 |
210 |
358 |
180 |
141 |
501 |
215 |
0,340 |
=0,001 |
Hormazabal 2014 3131 Mocellin S, Marincola FM, Young HA. Interleukin-10 and the immune response against cancer: a counterpoint. J Leukoc Biol. 2005;78(5):1043-1051. doi:10.1189/jlb.0705358. https://doi.org/10.1189/jlb.0705358...
|
Chile (latinos) |
147 |
172 |
19 |
73 |
55 |
111 |
183 |
11 |
83 |
78 |
105 |
239 |
0,694 |
0,070 |
Yin 2015 5050 Yin J, Wang X, Wei J, Wang L, Shi Y, Zheng L,et al. Interleukin 12B rs3212227 T>G polymorphism was associated with an increased risk of gastric cardiac adenocarcinoma in a Chinese population. Dis esophagus Off J Int Soc Dis Esophagus. 2015;28(3):291-298. doi:10.1111/dote.12189. https://doi.org/10.1111/dote.12189...
|
China (asiáticos) |
228 |
461 |
112 |
96 |
20 |
320 |
136 |
235 |
184 |
42 |
654 |
268 |
0,290 |
0,490 |
de Oliveira 2015 66 de Oliveira JG, Rossi AF, Nizato DM, Cadamuro AC, Jorge YC, Valsechi MC, et al. Influence of functional polymorphisms in TNF-a, IL-8, and IL-10 cytokine genes on mRNA expression levels and risk of gastric cancer. Tumor Biol. 2015;36(12):9159-9170. doi:10.1007/s13277-015-3593-x. https://doi.org/10.1007/s13277-015-3593-...
|
Brasil (latinos) |
207 |
240 |
104 |
82 |
21 |
290 |
124 |
169 |
64 |
7 |
402 |
78 |
0,162 |
0,753 |
Ma 2016 2828 Ma B, Zhang T, Wan Y, Zhan F. [A case-control study of interleukin-10 gene -592A/C polymorphism and the risk of gastric cancer]. [Article in Chinese].
|
China (asiáticos) |
147 |
150 |
67 |
63 |
17 |
197 |
97 |
71 |
67 |
12 |
208 |
92 |
0,303 |
0,486 |