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INVESTIGATION • An. Bras. Dermatol. 95 (3) • May-Jun 2020 • https://doi.org/10.1016/j.abd.2019.09.028 linkcopy

Open-access Immunostaining study of cytokeratins in human hair follicle development☆,☆☆

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    Abstract

    Background:  The hair follicle is a unique structure, one of the most dynamic structures in mammalians, which can reproduce in every new cycle all the mechanism involved in its fetal development. Although a lot of research has been made about the human hair follicle much less has been discovered about the importance of the cytokeratins (CKs) in its development.

    Objective:  Study the immunohistochemical pattern of epithelial CKs during human hair follicle development.

    Methods:  We performed an immunohistochemical study using fresh post-mortem skin biopsies of human fetuses between 4 and 25 weeks of gestational age to study the expression of cytokeratins (CKs): CK1, CK10, CK13, CK14, CK16 and CK20 during human hair follicle fetal development.

    Study limitations:  Restrospective study with a good number of makers but with a small population.

    Results/conclusion:  We found that, the CKs were expressed in an intermediate time during follicular development. The epithelial CKs (CK1, CK14, CK10, CK13) and the epithelial CKs with a proliferative character such as CK16 were expressed first, as markers of cellular maturation and follicular keratinization. At a later phase, CK20 was expressed in more developed primitive hair follicles as previously discussed in literature.

    KEYWORDS
    Hair follicle; Hair-specific; Keratins; Molecular; Pathology

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