Sweet syndrome
|
AML, chronic myeloid neoplasms, AMML Rarely: monoclonal gammopathies, MM, lymphoid neoplasms |
Erythematous or violaceous and painful nodules, papules, and plaques |
Systemic corticoids
Potassium iodide
Dapsone
Colchicine
|
Pyoderma gangrenosum
|
AML
Others: MDS, CML, PV, essential thrombocythemia, myelofibrosis
|
Classic form: painful ulcer with irregular, undermined violaceous borders, sterile inflammatory exudate and necrotic base
Bullous form: bullae with blue-gray borders progressing to shallow erosion/ulcers - face and arms
Vegetans form: Erythematous, exophytic, and verrucous lesions -head and neck Pustular form: painful pustules on an erythematous base
|
Local wound care - zinc oxide or petrolatum on wound borders
Mild cases: High-potency topical corticosteroids or calcineurin inhibitors; intralesional corticosteroids
Extensive cases: Systemic corticosteroid; Ciclosporin
Others: pulse therapy with methylprednisolone, methotrexate, mycophenolate, colchicine, sulfasalazine, dapsone, minocycline, apremilast, thalidomide
Immunobiologicals: infliximab, adalimumab, etanercept, ustekinumab
Refractory disease: intravenous immunoglobulin, cyclophosphamide, chlorambucil
|
Subcorneal pustulosis
|
IgA paraproteinemia
Others: IgA myeloma, aplastic anemia, lymphomas, CML, PV
|
Pustules with serpiginous distribution - trunk and intertriginous areas
Larger pustules: secretion collected in the lower portion (half and half).
|
Dapsone
Phototherapy, topical corticosteroids, systemic corticosteroids, and acitretin
|
Neutrophilic eccrine hidradenitis
|
AML and CML with or without chemotherapy Others: LLC B, myelomonocytic leukemia, ESL and non-Hodgkin’s lymphoma |
Disseminated erythematous, edematous, pruriginous, or painful plaques - hands, face, extremities |
Systemic corticoid
Dapsone
|
Eosinophilic dermatosis
|
LLC B
Others: B-cell lymphoproliferative diseases, acute T-lymphoma and leukemia
|
Pruriginous papules, vesicles, bullae or nodules. Similar to insect bite reaction. |
Topical corticoid
Phototherapy
Systemic corticoid
Dapsone
Immunosuppressants: methotrexate, azathioprine, lenalidomide, dupilumab
|
Pruritus
|
Myeloproliferative neoplasms (CML, PV, primary myelofibrosis), essential thrombocytosis Hodgkin’s and non-Hodgkin’s lymphomas |
Most common: Aquagenic pruritus - an itching, stinging, burning, or prickling sensation after contact with water on the skin |
Serotonin reuptake inhibitors -paroxetine
Anticonvulsants - gabapentin, pregabalin
Opioid receptor antagonist -Naltrexone
Phototherapy
Acetylsalicylic acid in PV
Neurokinin-1 receptor antagonist: aprepitant
Corticosteroids in intractable cases
Thalidomide in patients receiving palliative care
|
Cutaneous small vessel vasculitis
|
MDS
Others: AML, CML, myelofibrosis, PV, essential thrombocythemia
|
Painful/pruriginous palpable purpura
Mainly: distal lower limbs
|
Treatment of the underlying disease
Systemic corticoid
|
Polyarteritis nodosa
|
Hairy cell leukemia |
Subcutaneous nodules, palpable purpura, livedo reticularis or racemosa, ulcerations and bullae
Mainly: lower limbs
|
High-dose systemic corticosteroids
Immunosuppressants: methotrexate, cyclophosphamide
|
Erythema elevatum diutinum
|
IgA type monoclonal gammopathies
MDS
|
Erythematous violaceous papules, nodules, or plaques - extensor surfaces of limbs |
Dapsone
Localized cases: intralesional corticosteroid, surgical excision
|
Paraneoplastic pemphigus
|
Non-Hodgkin’s lymphoma
CLL
Castleman’s disease
Waldenström’s macroglobulinemia
|
Erosions progressing to severe oral and conjunctival ulcerations -entire oropharyngeal surface/lip vermilion
Severe membranous pseudoconjunctivitis
|
Prednisone
Ciclosporin
Cyclophosphamide
Other agents: rituximab, alemtuzumab
|
Acquired ichthyosis
|
Hodgkin’s lymphoma
Others: Non-Hodgkin
lymphoma, cutaneous T-cell lymphoma, leiomyosarcoma, MF, MM
|
Hypochromic/gray rhomboid scales with lamellar roughness/desquamation.
Similar to fish scales
Trunk and limbs - extensor surfaces, sparing flexures
|
Skin hydration
Keratolytic agents
Treatment of the underlying disease
|
Erythema nodosum
|
LMA, LMC, LMMC |
Tender, erythematous nodules and plaques 1-6 cm in diameter
Symmetrical lesions in lower/pre-tibial distal extremities
|
Compression bandages and limb elevation
NSAIDs
Systemic corticosteroid, potassium iodide, colchicine, dapsone, hydroxychloroquine
|
Diffuse plane xanthoma
|
MM
Monoclonal gammopathies
|
Irregular, diffuse, symmetrical, asymptomatic yellow-orange macules or plaques
Predilection for face, trunk and intertriginous areas
|
Remission of the haematological condition results in cutaneous improvement |
Scleromyxedema
|
MM
Other: lymphomas, Waldenström’s macroglobulinemia and AMML
|
Generalized eruption of firm, waxy, 2-3 mm, cupuliform/flat papules -hands, forearms, head, neck, trunk, and upper thighs
Linear distribution with surrounding shiny and hardened skin (sclerodermoid)
|
First line: Intravenous immunoglobulin
Thalidomide (or lenalidomide)
Systemic corticosteroid
Extracorporeal photochemotherapy
PUVA
Electron beam, topical corticosteroids/retinoids
|
Necrobiotic xanthogranuloma
|
Monoclonal gammopathy and multiple myeloma
Others: Non-Hodgkin’s and Hodgkin’s lymphoma, Waldenström’s macroglobulinemia, MDS, CLL
|
Multiple, asymptomatic, yellowish to reddish-brown indurated papules and nodules.
Slow evolution to large plaques.
|
Topical and systemic corticosteroids, thalidomide, high-dose intravenous immunoglobulin (IVIG), chlorambucil, among others |
Prurigo
|
Leukemia and Hodgkin’s disease |
Symmetrically distributed papules, hyperkeratotic or excoriated nodules, and scars.
Lower limbs and trunk -areas accessible to scratching
|
Diagnosis and treatment of the underlying disease
Topical corticosteroids, phototherapy and antihistamines - little effective
|