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Syndrome in Question* * Work performed at the the Third Affiliated Hospital and First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

Immunoglobulin light chain amyloidosis is the most common acquired systemic amyloidosis. Its presentation is often insidious and progressive, which may delay diagnosis. The authors describe a rare case of immunoglobulin light chain amyloidosis in a 34-year-old man with scleroderma-like manifestation substantiated by multifarious laboratory investigations and the histopathologic feature of involved skin lesions stained with Congo red and crystal violet. This helps to maintain a high clinical suspicion of the disease when confronting similar skin presentation.

Amyloidosis; Scleroderma, diffuse; Skin manifestations


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