1 |
Friedman et al. (2005)11 Friedman DR, Wolfsthal SD. Cocaine-induced pseudovasculitis. Mayo Clin Proc. 2005;80(5):671-3.
|
27 F |
NR |
NR |
Face, legs, arms and back. Septum destruction, ethmoidal and maxillary sinusitis |
Yes |
No |
No |
ANAs+ 1:640, p-ANCAS + against PR3 |
NR |
Yes |
2 |
E. Roche et al. (2008)22 Roche E, Martínez-Menchón T, Sánchez-Carazo JL, Oliver V, De Miquel VA. Two cases of eruptive pyoderma gangrenosum associated with cocaine use. Actas Dermosifiliogr. 2008;99:727-30.
|
30 M |
2 years |
3 months |
Initially back, later trunk and limbs |
Yes |
No |
No |
No |
Cyclosporine, topical methotrexate, tacrolimus, and infliximab after interrupting cocaine consumption |
Yes |
3 |
E. Roche et al. (2008)22 Roche E, Martínez-Menchón T, Sánchez-Carazo JL, Oliver V, De Miquel VA. Two cases of eruptive pyoderma gangrenosum associated with cocaine use. Actas Dermosifiliogr. 2008;99:727-30.
|
37 M |
10 years |
4 months |
Back, upper third of the arms, and cheek |
Yes |
Yes |
No |
No |
Infliximab, topical tacrolimus, associated with cocaine abstinence |
No |
4 |
Camilla Bezerra da Cruz Maia et al. (2012)33 da Cruz Maia Cb, Felix F, Paes V, de Azevedo Ja, Grangeiro Ern, Riccio Jln, et al. Nasal septum perforation in patient with pyoderma gangrenosum. Int Arch Otorhinolaryngol. 2012;16:278-81.
|
27 F |
10 years |
5 years |
Left half-face and inferior members. Hard palate and nasal septum destruction |
Yes |
No |
No |
No |
Azathioprine and prednisone resulted satisfactory with partial healing of the face |
No |
5 |
D. Jimenez-Gallo et al. (2013)44 Jiménez-Gallo D, Albarrán-Planelles C, Linares-Barrios M, Rodríguez-Hernández C, Martínez-Rodríguez A, García-Moreno E, et al. Pyoderma gangrenosum and Wegener granulomatosis-like syndrome induced by cocaine. Clin Exp Dermatol. 2013;38:878-82.
|
54 F |
5 years |
2 months |
Both legs. Saddlenose nasal deformity associated with oronasal fistula |
Yes |
No |
Retiform purpura and lung involvement |
p-ANCAS+ 1:80 for elastase and ANAs 1:40 |
Cyclophosphamide bolus |
Yes |
6 |
Phillip J. Keith et al. (2014)55 Keith PJ, Joyce JC, Wilson BD. Pyoderma gangrenosum: A possible cutaneous complication of levamisole-tainted cocaine abuse. Int J Dermatol. 2014;54:1075-7.
|
51 F |
NR |
2 months |
Face, abdomen, back, thigh and pubis |
Yes |
No |
No |
P-ANCA+ > 1:640, ANAs+, AL+, ACL+ |
Prednisone and cocaine abstinence |
No |
7 |
Haneol S. Jeong et al. (2015)66 Jeong HS, Layher H, Cao L, Vandergriff T, Dominguez AR. Pyoderma gangrenosum (PG) associated with levamisole-adulterated cocaine: Clinical, serologic, and histopathologic findings in a cohort of patients. J Am Acad Dermatol. 2015;74:892-8.
|
n = 8; ages and sex NR |
NR |
1 week to 4 weeks (median: 1 week) |
Lower limbs (n = 8), upper limbs (n = 6), trunk (n = 3), face (n = 3) |
Yes |
n = 5 |
Retiform purpura (n = 3). Artrhalgias (n = 1) |
ACL+ (n = 5), AL+ (n = 3), B2GP+ (n = 4) p-ANCA+ (n = 7), anti PR3+ (n = 4) y anti-MPO+ (n = 7), ANAs+ (n = 3) and FR+ (n = 1) |
Prednisone were administered in 6 of 8 patients. Gentle wound care and cocaine avoidance in all patients with improvement |
Yes |
8 |
Carola Baliu-Piqué et al. (2016)99 Baliu-Piqué C, Mascaró JM. Multifocal and refractory pyoderma gangrenosum: Possible role of cocaine abuse. Australas J Dermatol. 2016;58:e83-6.
|
40 F |
NR |
2 weeks |
Breast, hips, upper and lower extremities |
Yes |
No |
No |
No |
Methylprednisolone bolus, cyclosporine, infliximab, and mycophenolic acid |
Yes |
9 |
Ricardo Ruiz-Villaverde et al. (2016)77 Ruiz-Villaverde R, Sánchez-Cano D. Multiple Pyoderma Gangrenosum Ulcers Associated with Cocaine Abuse. Sultan Qaboos Univ Med J. 2016;16:e527-8.
|
38 M |
NR |
NR |
Armpits, chest, pubis, and lumbar region |
Yes |
No |
No |
No |
Prednisone |
Yes |
10 |
Rahul Sehgal et al. (2017)88 Sehgal R, Resnick JM, Al-Hilli A, Mehta N, Conway T, Stratman EJ. Nasal septal and mucosal disease associated with pyoderma gangrenosum in a cocaine user. JAAD Case Reports. 2017;3:284-7.
|
53 F |
NR |
6 months |
On the upper back. Ulceration of bilateral nasal passages and nasal septum perforation |
Yes |
No |
Right-sided multifocal pneumonitis and mild reactive lymphadenopathy. |
No |
Intralesional triamcinolone, local wound care, prednisone, dapsone, topical tacrolimus, cyclosporine, and cocaine discontinuation, resulting in gradual improvement |
Yes |
11 |
Ester Moreno-Artero et al. (2018) 1010 Moreno-Artero E, Querol-Cisneros E, Rodríguez-Garijo N, Tomás-Velásques A, Idoate MA, Gil-Sánchez MP, et al. Cocaine-induced pyoderma gangrenosum-like lesions. J Dtsch Dermatol Ges. 2018;16:763-8.
|
37 M |
NR |
4 years |
Cheeks and right gluteal area |
Yes |
No |
No |
c-ANCAS + against PR3 and AL+ |
NR |
Yes |
12 |
Ester Moreno-Artero et al. (2018) 1010 Moreno-Artero E, Querol-Cisneros E, Rodríguez-Garijo N, Tomás-Velásques A, Idoate MA, Gil-Sánchez MP, et al. Cocaine-induced pyoderma gangrenosum-like lesions. J Dtsch Dermatol Ges. 2018;16:763-8.
|
34 F |
NR |
20 days |
Both hands, lower back, and lower limbs |
Yes |
No |
No |
p-ANCAs + against elastase |
NR |
Yes |
13 |
Ester Moreno-Artero et al. (2018) 1010 Moreno-Artero E, Querol-Cisneros E, Rodríguez-Garijo N, Tomás-Velásques A, Idoate MA, Gil-Sánchez MP, et al. Cocaine-induced pyoderma gangrenosum-like lesions. J Dtsch Dermatol Ges. 2018;16:763-8.
|
43 M |
3 years |
6 months |
Face, trunk, and lower limbs |
Yes |
No |
No |
ANCAs + against elastase |
NR |
Yes |
14 |
Andrea Estébaneza et al. (2020)1111 Estébanez A, Silva E, Abdilla N. Letter to the Editor Ulcerative pyoderma gangrenosum associated. Med Clin. 2020;154:373-7.
|
40 F |
NR |
6 months |
Back, chin, and retroauricular area, destruction of the nasal septum and the lateral maxillary sinus wall |
Yes |
No |
Left posterior perirenal and pararenal esteril abscess |
No |
Corticosteroids and cessation of cocaine use through a rehabilitation program, skin lesions and kidney abscess resolved. |
No |
15 |
Andrea Estébaneza et al. (2020) 1111 Estébanez A, Silva E, Abdilla N. Letter to the Editor Ulcerative pyoderma gangrenosum associated. Med Clin. 2020;154:373-7.
|
51 M |
NR |
NR |
Right Achilles tendon lesion |
Yes |
Yes |
No |
No |
Prednisone and cocaine consumption were temporarily interrupted |
Yes |
16 |
Andrea Estébaneza et al. (2020) 1111 Estébanez A, Silva E, Abdilla N. Letter to the Editor Ulcerative pyoderma gangrenosum associated. Med Clin. 2020;154:373-7.
|
54 M |
NR |
2 weeks |
Back |
Yes |
No |
No |
ANAs+ (title 1/320). |
Corticosteroid |
Yes |