Serum levels of 25-hydroxy vitamin D in psoriatic patients

Zuchi, Manuela Ferrasso; Azevedo, Paula de Oliveira; Tanaka, Anber Ancel; Schmitt, Juliano Vilaverde; Martins, Luis Eduardo Agner Machado

doi:10.1590/abd1806-4841.20153524

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Communication • An. bras. dermatol. 90 (3) • June 2015 • https://doi.org/10.1590/abd1806-4841.20153524 copy

Serum levels of 25-hydroxy vitamin D in psoriatic patients^* * Study carried out at the Dermatology Service of the Teaching Hospital of the Evangelical College of Curitiba (HUEC-FEPAR) – Curitiba (PR), Brazil.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Studies have shown a relationship between vitamin D and psoriasis. We compared serum levels of vitamin D of 20 psoriasis patients and 20 controls. The median vitamin D level was 22.80 ± 4.60 ng/ml; the median in the cases was 23.55 ± 7.6 ng/ml, and in controls 22.35 ± 3.10 ng/ml (p = 0.73). Only 2 cases and 4 controls had sufficient levels of vitamin D, although without statistical significance between the groups (p = 0.608). Levels were lower in women with psoriasis compared with those in male patients (20.85 ± 6.70 x 25.35 ± 2.90 ng/ml, p = 0.03), a finding that was not observed among controls.

Keywords:
Psoriasis; Vitamin D; Vitamin D deficiency

Variable		Psoriasis	Controls	Odds ratio	p
Variable		(n=20)	(n=20)	Odds ratio	p
Sex¹ 1 Represented by absolute numbers	Females	12	14	Reference	-
	Males	8	6	1.56 (0.42 to 5.76)	0.531² 2 Fisher’s Exact test
Current age³ 3 Means and standard deviations		46.40±14.90	47.80±18,.6	-	0.860⁴ 4 Unpaired Student’s t-test
Phototype¹ 1 Represented by absolute numbers	1-2	10	11	Reference	-
	3	4	5	0.88 (0.18 to 4.23)	0.999² 2 Fisher’s Exact test
	4-5	6	4	1.65 (0.36 to 7,60)	0.704² 2 Fisher’s Exact test
Daily direct sun exposure (min.)⁵ 5 Medians and interquartile deviation		25.0±10.0	35.0±100.0	-	0.156⁶ 6 Nonparametric Mann-Whitney test
25-Hydroxyvitamin D⁵ 5 Medians and interquartile deviation		23.55±7.60	22.35±3.10	-	0.735⁶ 6 Nonparametric Mann-Whitney test
Deficiency VD¹ 1 Represented by absolute numbers ^,⁷ 7 VD: Vitamin D; Strata defi ned according to reference values of the laboratory performing serum dosage of 25-hydroxyvitamin D: defi ciency (<20ng/ml), insuffi ciency (>=20 and <30ng/ml) and suffi ciency (>=30ng/ml).		5	4	Reference	-
Insufficiency VD¹ 1 Represented by absolute numbers ^,⁷ 7 VD: Vitamin D; Strata defi ned according to reference values of the laboratory performing serum dosage of 25-hydroxyvitamin D: defi ciency (<20ng/ml), insuffi ciency (>=20 and <30ng/ml) and suffi ciency (>=30ng/ml).		13	12	0.87 (0.19 to 4.01)	0.999² 2 Fisher’s Exact test
Sufficiency VD¹ 1 Represented by absolute numbers ^,⁷ 7 VD: Vitamin D; Strata defi ned according to reference values of the laboratory performing serum dosage of 25-hydroxyvitamin D: defi ciency (<20ng/ml), insuffi ciency (>=20 and <30ng/ml) and suffi ciency (>=30ng/ml).		2	4	0.40 (0.05 to 3.42)	0.608² 2 Fisher’s Exact test

Variable		Female	Male	Odds ratio	p
Variable		(n=12)	(n=8)	Odds ratio	p
Current age¹ 1 Means and standard deviations		43.50±14.00	50.50±31.00	-	0.537² 2 Unpaired Student’s t-test
Phototype³ 3 Represented by absolute numbers	1-2	6	4	Reference	-
	3-5	6	4	1.00 (0.17 to 5.98)	0.9994
Age of psoriasis onset (years) ¹ 1 Means and standard deviations		38.58±12.41	33.38±27.12	-	0.5892
PASI⁵ 5 Medians and interquartile deviation ^'⁶ 6 “Psoriasis Area Severity Index”		1.70±3.40	3.20±5.70	-	0.2177
DLQI⁵ 5 Medians and interquartile deviation ^,⁸ 8 “Dermatology Life Quality Index”.		2.50±3.00	7.50±5.00	-	0.1147
Daily direct sun exposure (min.)⁵ 5 Medians and interquartile deviation		20.0±10.0	45.0±40.0	-	0.0497
25-Hydroxyvitamin D⁵ 5 Medians and interquartile deviation		20.85±6.70	25.35±2.90	-	0.0317

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E-mail: revista@sbd.org.br

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[1] MAILING ADDRESS: Manuela Ferrasso Zuchi, Carlos de Carvalho, 1652 - Batel, 80730-200 - Curitiba - PR, Brazil. E-mail: manuzuchi@hotmail.com

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Serum levels of 25-hydroxy vitamin D in psoriatic patients* * Study carried out at the Dermatology Service of the Teaching Hospital of the Evangelical College of Curitiba (HUEC-FEPAR) – Curitiba (PR), Brazil.

Abstract

Serum levels of 25-hydroxy vitamin D in psoriatic patients^* * Study carried out at the Dermatology Service of the Teaching Hospital of the Evangelical College of Curitiba (HUEC-FEPAR) – Curitiba (PR), Brazil.