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Case Report • An. Bras. Dermatol. 95 (4) • Jul-Aug 2020 • https://doi.org/10.1016/j.abd.2019.02.007   copy

Successful therapeutic approach in a patient with elephantiasic pretibial myxedema☆ ☆ How to cite this article: Ferreira M, Zacaron LH, Valle AF, Gamonal ACC. Successful therapeutic approach in a patient with elephantiasic pretibial myxedema. An Bras Dermatol. 2020;95:469-72. ,☆☆ ☆☆ Study conducted at the University Hospital, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Localized pretibial myxedema is a dermopathy whose treatment is a challenge in dermatology, occurring in 0.5-4% of patients with Graves’ disease. This autoimmune thyroid condition stimulates the production of hyaluronic acid and glycosaminoglycans that are deposited particularly in the pretibial region. Clinically, it presents as a localized, circumscribed, and non-depressible infiltrate in plaques. Several treatment modalities have been proposed, and their results vary, with worse response observed in severe cases. This report presents the case of a patient with elephantiasic pretibial myxedema who was subjected to intralesional corticosteroid applications, resulting in an excellent and encouraging therapeutic response that was maintained.

KEYWORDS
Evaluation of results of therapeutic interventions; Myxedema; Steroids; Therapeutics

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