Melanocytic matricoma: a pigmented lesion on the forehead^☆

Dear Editor,

A 74-year-old woman presented to our outpatient dermatology clinic with a 4-year history of an asymptomatic, pigmented tumor located on the forehead. On physical examination, we found a 5 mm, dark brown colored papule, surrounded by an erythematous rim. Past medical history was unremarkable. On dermoscopy, we found blue-gray ovoid nests, ulceration and peripheral telangiectasias (Fig. 1). The tumor was clinically diagnosed as pigmented basal cell carcinoma. A cutaneous biopsy was performed, and the histopathologic study revealed an epithelial, well-circumscribed neoformation that was composed of basophilic cells with hyperchromatic nuclei, a scarce cytoplasm, and prominent nucleoli. Mixed with these basaloid cells, there were multiple cells with basophilic nuclei and eosinophilic cytoplasm that were arranged in small nests. Sparse ghost cells were also found. There were multiple dendritic and pigmented melanocytes as well as areas of compacted keratinization (Fig. 2). Immunohistochemical study with BerEP4 turned positive in basaloid areas. Melanocytic matricoma diagnosis was concluded and a complete tumor resection was performed. The patient remained clinically disease-free during follow-up consultation.

Figure 1
Physical examination. (A) A dark brown-black colored papule. (B) Dermoscopy. Blue-gray ovoid nests and ulceration, surrounded by a 3 mm erythematous and elevated rim.

Figure 2
Histopathology findings (A) Well circumscribed tumor arranged in lobes (Hematoxylin & eosin, 4×). (B) Basaloid and ghost cells with compact keratinization (Hematoxylin & eosin, 10×). (C) Basaloid cells and numerous dendritic melanocytes (Hematoxylin & eosin, 20×). (D) Dendritic pigmented melanocytes (Hematoxylin & eosin, 40×).

Melanocytic matricoma is considered an adnexal tumor with matrical differentiation.¹,² This newly described neoformation predominates in males, and it is strongly associated with sun-damaged skin in elderly patients, with a mean age of 71 years at presentation.³,⁴ Only 32 cases have been reported in international literature. This uncommon tumor is predominantly located on the head, particularly in the nose and preauricular area, but it has also been reported on the neck, trunk, and extremities.⁴ Its classical clinical presentation is described as a small, well-circumscribed, nodular tumor with an asymmetric dark pigmentation.¹,⁴ Melanocytic matricoma is a biphasic tumor that comprises an epithelial component with matrical differentiation, and a melanocytic component with dendritic melanocytes. The epithelial component consists of basaloid cells with scarce cytoplasm, round nuclei, dotted nuclear chromatin, and prominent nucleoli. These basaloid cells might acquire mild to moderate pleomorphism with a slightly elevated mitotic activity, thus denominated matrical and supramatrical cells. These cells show an abrupt or gradual transition to ghost cells. In contrast, the melanocytic component appears as a well-circumscribed arranged nodule that is composed of melanocytes, intermixed with matrical and supramatrical cells, as well as foci of ghost cells. The epithelial component shows positivity for cytokeratin and beta-catenin, whereas dendritic melanocytes are highlighted by HMB-45, S-100, and Melan-A.⁵ Most tumors involve superficial to deeper dermis, without an evident epidermal or adnexal connection.¹ The histopathologic and immunohistochemical findings suggest that melanocytic matricoma resembles anagen hair growth. Therefore, melanocytic matricoma is currently classified as a cutaneous adnexal tumor with both follicular and matrical differentiation.⁴

Clinical differential diagnosis includes basal cell carcinoma, melanoma, and hemangioma, but the main clinical differential diagnosis is pilomatrixoma¹ (Table 1).⁶-⁸ This benign cutaneous tumor is found predominantly in young females (average 20 years), localized frequently on the neck and extremities, and it is clinically presented as a multilobulated and firm subcutaneous nodule. In contrast, histopathologic differential diagnosis includes tumors with matrical differentiation, such as pilomatrixoma, pigmented pilomatrixoma, and basal cell carcinoma with matrical differentiation (Table 2).⁹

Table 1
Differential diagnosis of melanocytic matricoma.⁴,⁶.

	Melanocytic Matricoma	Pilomatrixoma	Basal Cell Carcinoma	Melanoma
Common age group	Elderly individuals	Children, younger than 10 years.	Adults, elderly	Young and middle-aged individuals
Sex	M > F	F > M	M > F	F > M
Size (cm)	0.2 ‒ 1.5	0.5 ‒ 3	0.5 ‒ 10	Variable
Clinical Features	Pigmented nodule, polypoid or exophytic, rarely ulcerated.	Solitary, asymptomatic, slow growing, cystic, or firm nodule.	Slow growing, ulcerated nodule or plaque.	Asymmetric macule or nodule with irregular borders, might present variations in color within the lesion
Sun Damaged Skin	Significant	Not significant	Significant	Not significant
Dermoscopy	Homogeneous blue or patched pigmentation. Fork-shaped glasses	Blue pigmentation, dilated vessels.	Large gray-blue ovoid nests, multiple blue-gray globules, maple leaf-like areas	Atypical network, blue whitish veil, atypical vascular pattern, irregular globules, irregular streaks, regression structures
Site	Head and neck, upper extremities.	Head and neck, upper extremities.	Head and neck, upper extremities (arms and hands).	Trunk, limbs, acral regions, head

Table 2
Histopathological differences between melanocytic matricoma, pigmented pilomatrixoma and pigmented basal cell carcinoma with matrical differentiation.⁴,⁹,¹⁰

	Pigmented Pilomatrixoma	Melanocytic Matricoma	Pigmented Basal Cell Carcinoma with Matrical Differentiation
Epidermis involvement	Any	Atrophic, or hyperkeratotic with acanthosis	Any
Histopathological pattern	Nodular or multinodular with cystic areas	Single solid well-defined nodule, usually no cystic areas	Nodular pattern accompanied by either superficial pattern, cystic change or an infiltrative pattern
Location in the dermis	In deep dermis with frequent extension to adipose tissue	In superficial to medium reticular dermis	Dermis to subcutaneous tissue in some cases
Cell types	Variable mixture of basaloid, transitional and ghost cells	Matrix and supra-matrix cells, few occasional ghost cells	Basaloid follicular and germinative cells, ghost cells with basaloid appearing matrical cells in periphery
Keratinization Type	Pilar and sometimes infundibular keratinization	Pilar keratinization	Central abrupt matrical keratinization
Histopathological alterations of the dermis	Connective tissue: Blood vessels, infiltrate of mixed inflammatory cells, giant foreign body cells.	Sclerotic stromal response, actinic elastosis	Actinic elastosis
	Sometimes: hemosiderin, melanin, bone and, rarely, amyloid deposition.
Calcium deposition	In 80% of cases	Infrequent	Presented in some cases
Foreign body reaction	Very frequent	Infrequent	Infrequent
Ghost cells	In the center of the tumor, almost always present	Present in small foci mixed with pigmented, dendritic melanocytes	Present in most of the tumor
Mitosis	There may be cytological atypia and mitotic figures	There may be cytological atypia and mitotic figures	Present cytologic atypia and high mitotic figures
Melanin	Melanin is rare, some dendritic melanocytes	Pigmented, inside melanophages, and dentritic melanocytes distributed asymmetrically.	Tumor cells with melanin in cytoplasm. No prominence of intra tumoral melanocytes

The importance of recognizing this recently described tumor is based on its unknown prognosis and lack of treatment options, besides surgery. Therefore, it is important to consider melanocytic matricoma in elderly, sun-damaged skin patients with a newly discovered pigmented neoplasm, besides pigmented basal cell carcinoma and melanoma, requiring wider surgical margins and a closer follow-up. It is essential to report all melanocytic matricoma cases to establish its clinical course and prognostic features.

• Financial support

  None declared.
• ☆
  Study conducted at the General Hospital “Dr. Manuel Gea González”, México City, Mexico.

References

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• ²
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  Soler AP, Burchette JL, Bellet JS, Olson JA Jr. Cell adhesion protein expression in melanocytic matricoma. J Cutan Pathol. 2007;34:456-60.
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  Kyrpychova L, Carr RA, Martinek P, Vanecek T, Perret R, Chottová-Dvořáková M, et al. Basal cell carcinoma with matrical differentiation: clinicopathologic, immunohistochemical, and molecular biological study of 22 cases. Am J Surg Pathol. 2017;41:738-49.

Publication Dates

• Publication in this collection
  23 Sept 2024
• Date of issue
  Sep-Oct 2024

History

• Received
  12 Feb 2023
• Accepted
  21 May 2023