Cutaneous T-cell lymphomas in the revised 4<sup>th</sup> edition of World Health Organization classification of tumors of hematopoietic and lymphoid tissues (2017)

Xavier Júnior, Jose Candido Caldeira; Ocanha-Xavier, Juliana Polizel

doi:10.1590/abd1806-4841.20188057

Acessibilidade / Reportar erro

Brasil

Anais Brasileiros de Dermatologia

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

Dermatopathology • An. Bras. Dermatol. 93 (6) • Nov/Dec 2018 • https://doi.org/10.1590/abd1806-4841.20188057 copy

Cutaneous T-cell lymphomas in the revised 4^th edition of World Health Organization classification of tumors of hematopoietic and lymphoid tissues (2017)^* * Work conducted at the Faculdade de Medicina, Centro Universitário Católico Unisalesiano Auxilium, Araçatuba (SP), Brazil.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract:

Recently, the World Health Organization published the revised 4th edition of its classification of tumors of hematopoietic and lymphoid tissues. The present paper is a concise comparative review of the main primary cutaneous T-cell hematopoietic tumors, with emphasis on their immunohistochemical profiles.

Keywords:
Dermatology; Immunohistochemistry; Lymphoma, T-Cell, cutaneous; Pathology

Type	Frequency	Histology	Immunohistochemistry
A	>80%	Sparse large and atypical neoplastic cells amid mixed inflammatory infiltrate	CD4+, CD8-
B*	<5%	Epidermotropic Infiltrate of small lymphocytes	CD4+, CD8-
C	~10%	Cohesive infiltrate of large and atypical cells among sparse inflammatory cells	CD4+, CD8-
D	<5%	Infiltration of small and medium atypical epider- motropic cells.	CD4-, CD8+
E	<5%	Angiocentric and angiodestructive pattern	CD4-, CD8+
Rearrangement DUSP22-IRF4	<5%	Small and epidermotropic lymphocytes associated with large neoplastic cells in the dermis (similar to transforming MF)	CD4-, CD8+ ou CD4-, CD8-

Disease	CD3	CD4	CD8	Cytotoxic markers^a a = Granule-associated cytotoxic proteins: TIA1, granzyme B, perforin;	CD56	EBV	CD30
MF	+	+	-/+	-	-	-	-/+
LyP	+	+/-	-/+	+/-	-	-	+
C-ALCL	+	+/-	-/+	+/-	-	-	+
SPTCL	+	-	+	+	-	-	-
PCGD-TCL	+	-	-/+	+	+	-	-
AECTCL	+	-	+	+	-/+	-	-
CD8+ LP	+	-	+	-^b b = TIA1 can present positive expression in dot pattern; MF: mycosis fungoides; LyP: lymphomatoid papulosis; C-ALCL: Primary cutaneous anaplastic large cell lymphoma; SPTCL: Subcutaneous panniculitis-like T-cell lymphoma; PCGD-TCL: Primary cutaneous gamma delta T-cell lymphoma; AECTCL: Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma; CD8+ LP: Primary cutaneous acral CD8+ T-cell lymphoma; PCSM-TCLD: Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder; HVLD: Hydroa vacciniforme-like lymphoproliferative disorder	-	-	-
PCSM-TCLD	+	+	-	-	-	-	-
HVLD	+	-/+	+	+	+	+	+/-

Sociedade Brasileira de Dermatologia Av. Rio Branco, 39 18. and., 20090-003 Rio de Janeiro RJ, Tel./Fax: +55 21 2253-6747 - Rio de Janeiro - RJ - Brazil
E-mail: revista@sbd.org.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] Mailing Address: Jose Candido Caldeira Xavier Júnior. E-mail: josecandidojr@yahoo.com.br

Brasil

Brasil

Cutaneous T-cell lymphomas in the revised 4th edition of World Health Organization classification of tumors of hematopoietic and lymphoid tissues (2017)* * Work conducted at the Faculdade de Medicina, Centro Universitário Católico Unisalesiano Auxilium, Araçatuba (SP), Brazil.

Abstract:

Cutaneous T-cell lymphomas in the revised 4^th edition of World Health Organization classification of tumors of hematopoietic and lymphoid tissues (2017)^* * Work conducted at the Faculdade de Medicina, Centro Universitário Católico Unisalesiano Auxilium, Araçatuba (SP), Brazil.