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Linear IgA and IgG bullous dermatosis* * Work performed at the Hospital Naval Marcílio Dias (HNMD) - Rio de Janeiro (RJ), Brazil.

Abstract

Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 might occur. It is still debated whether concomitant findings of immunoglobulins A and G should be considered a subtype of this dermatosis or a new entity. Further studies are needed to recognize this clinical variant.

Keywords:
Basement membrane; Immunoglobulin A; Linear IgA bullous dermatosis

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