Acessibilidade / Reportar erro
Images in Dermatology • An. Bras. Dermatol. 97 (02) • 2022 • https://doi.org/10.1016/j.abd.2021.03.011   copy

Scanning electron microscopy of panitumumab-induced eyelash and hair alterations - Pili canaliculi☆ ☆ Study conducted at the Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas and Liga de Dermatologia da Universidade Federal de Pelotas, Pelotas, RS, Brazil.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Panitumumab is a monoclonal antibody against the epidermal growth factor receptor used in metastatic colorectal cancer; in addition to tumor cells, it acts on epidermal keratinocytes and on the outer root sheath and presents skin toxicity in up to 90% of cases. A scanning electron microscope was used to examine the eyelashes and hairs of a 65-year-old patient with eyelash trichomegaly, curly hair, and paronychia undergoing treatment with panitumumab. Grooving in the hair shafts were identified, which were more evident in the eyelashes. Similar to oral epidermal growth factor inhibitors (erlotinib and gefitinib), panitumumab can cause acquired pili canaliculi.

Keywords:
Microscopy, electron; Panitumumab; Scalp dermatoses

Sociedade Brasileira de Dermatologia Av. Rio Branco, 39 18. and., 20090-003 Rio de Janeiro RJ, Tel./Fax: +55 21 2253-6747 - Rio de Janeiro - RJ - Brazil
E-mail: revista@sbd.org.br
Acompanhe os números deste periódico no seu leitor de RSS