Case 1 |
|
45 |
F |
No |
18 years |
No |
Face (submandibular, mentum, supralabial) |
Negative |
No |
Yes |
Yes |
Methotrexate 15mg/week, dapsone 100 mg/day, betamethasone dipropionate ointment, surgical excision (cysts) |
Improvement |
Case 2 |
|
85 |
F |
No |
1 year |
Yes |
Face (mandibular, malar) and cervical regions |
1:640 CSN |
Yes |
Yes |
No |
Hydroxychloroquine 400mg/day, systemic corticosteroid therapy, photoprotection |
Partial improvement |
Case 3 |
|
41 |
F |
Yes |
2 years |
Yes |
Face (paranasal, maxillae) and auricle |
1:160 FSN |
No |
Yes |
No |
Hydroxychloroquine 400 mg/day, methotrexate 15 mg/week, intralesional corticosteroid, photoprotection |
Partial improvement |
Case 4 |
|
50 |
F |
Yes |
2 years |
Yes |
Face (nasal, pre-auricular, malar, mentum) |
Negative |
No |
Yes |
No |
Methotrexate 15 mg/week, dapsone 100mg/day, tretinoin cream 0.025%, benzoyl peroxide 5%, doxycycline 200mg/day |
Partial improvement |
Case 5 |
|
62 |
F |
Yes |
15 years |
No |
Face (mentum, pre-auricular) and auricular region |
Negative |
No |
Yes |
No |
Topical corticosteroids, tretinoin cream 0.025% |
Improvement |
Haroon et al.33 Haroon TS, Fleming KA. An unusual presentation of discoid lupus erythematosus. Br J Dermatol. 1972;87:642-5.
|
1972 |
32 |
F |
No |
4 years |
Yes |
Back |
Negative |
No |
Yes |
No |
Not informed |
Not reported |
Motel et al.44 Motel PJ, Bernstein EF, FazioM, Humeniuk H, Kauh YC. Systemic lupus erythematosus in patients diagnosed with treatmentresistant acne. Int J Dermatol. 1995;34:338-40.
|
1995 |
24 |
F |
No |
Not informed |
No |
Face and cervical region |
1:5120 Nucleolar |
Yes |
No |
Yes |
Erythromycin 250 mg QID |
No improvement |
Motel et al.44 Motel PJ, Bernstein EF, FazioM, Humeniuk H, Kauh YC. Systemic lupus erythematosus in patients diagnosed with treatmentresistant acne. Int J Dermatol. 1995;34:338-40.
|
1995 |
29 |
F |
No |
7 years |
Yes |
Face and upper trunk |
1:2560 HN |
Yes |
No |
Yes |
Tetracycline and erythromycin |
No improvement |
Chang et al.55 Chang YH, Wang SH, Chi CC. Discoid lupus erythematosus presenting as acneiform pitting scars. Int J Dermatol. 2006;45:944-5.
|
2006 |
32 |
F |
No |
3 years |
No |
Face (nasolabial fold) |
Negative |
No |
Yes |
No |
Not reported |
Not reported |
El Sayed et al.66 El Sayed F, Dhaybi R, Ammoury A, Bazex J. Lupus comédonien [Lupus comedonicus]. Ann Dermatol Venereol. 2007;134:897-8. French.
|
2007 |
60 |
M |
No |
8 years |
Yes |
Face (malar) |
1:80 FSN |
No |
No |
No |
Hydroxychloroquine 400 mg/day, photoprotection, topical clobetasol and tazarotene |
Improvement |
Stavrakoglou et al.22 Stavrakoglou A, Hughes J, Coutts I. A case of discoid lupus erythematosus masquerading as acne. Acta Derm Venereol. 2008;88:175-6.
|
2008 |
38 |
M |
No |
7 years |
Yes |
Face, back and anterior thorax |
Negative |
No |
No |
Yes |
Hydroxychloroquine 400 mg/day, photoprotection |
Complete improvement in 1 year |
Hemmati et al.77 Hemmati I, Otberg N, Martinka M, Alzolibani A, Restrepo I, Shapiro J. Discoid lupus erythematosus presenting with cysts, comedones, and cicatricial alopecia on the scalp. J Am Acad Dermatol. 2009;60:1070-2.
|
2009 |
33 |
F |
No |
1,5 years |
No |
Scalp |
Not informed |
No |
Yes |
Yes |
Hydroxychloroquine 400 mg/day, photoprotection, triamcinolone infiltration, manual extraction |
Improvement |
Farias et al.88 Farias DF, Gondim RM, Redighieri IP, Muller H, Petri V. Comedonic lupus: a rare presentation of discoid lupus erythematosus. An Bras Dermatol. 2011;86:S89-91.
|
2011 |
35 |
F |
No |
2 years |
Yes |
Face (nasal dorsum, mentum) and ears |
Not informed |
No |
Yes |
Yes |
Hydroxychloroquine 400 mg/day, tetracycline, photoprotection |
Improvement in 6 months |
Ugarte et al.99 Ugarte C, Cheng F, Anodal M, Marcucci C, Hidalgo G, Sánchez G, et al. Lupus discoide: patrón de cicatrización acneiforme. A propósito de un caso. Arch Argent Dermatol. 2014;64:114-6.
|
2014 |
41 |
F |
- |
11 years |
No |
Face, pre-auricular and scalp regions |
1:320
|
No |
No |
- |
Hydroxychloroquine 400mg/day and prednisone 20mg/day |
Remission |
Deruelle-Khazaal et al.1010 Deruelle-Khazaal R, Ségard M, Cottencin-Charrière AC, Carotte-Lefebvre I, Thomas P. Lésions acnéiformes révélatrices d’un lupus érythémateux chronique [Chronic lupus erythematosus presenting as acneiform lesions]. Ann Dermatol Venereol. 2002;129:883-5.
|
2017 |
32 |
F |
No |
2 years |
Yes |
Face (mentum) and ear |
Positive
|
No |
Yes |
Yes |
Prednisone and chloroquine diphosphate |
Pruritus improvement |
Vieira et al.1111 Vieira ML, Marques ERMC, Leda YLA, Noriega LF, Bet DL, Pereira GAAM. Chronic cutaneous lupus erythematosus presenting as atypical acneiform and comedonal plaque: case report and literature review. Lupus. 2018;27:853-7.
|
2018 |
32 |
F |
No |
2 years |
Yes |
Face (mentum) |
Negative |
No |
Yes |
Yes |
Prednisone and chloroquine diphosphate |
Improvement in 3 months |
Mohanty et al.1212 Mohanty B, Kumar B. Systemic lupus erythematosus camouflaging: As refractory acne in a young girl. J Family Med Prim Care. 2019;8:276-9.
|
2019 |
20 |
F |
No |
8 months |
No |
Face, cervical, dorsum and abdomen |
Positive
|
Yes |
No |
Yes |
Methotrexate 15 mg/week, and hydroxychloroquine 200mg/day |
Not reported |
Droesch et al.11 Droesch C, Magro C. A comedonal variant of chronic cutaneous lupus erythematosus: case report and literature review. JAAD Case Rep. 2019;5:801-5.
|
2019 |
57 |
F |
No |
1 year |
No |
Face (malar, mentum, forehead) and cervical regions |
1:80 speckled nuclear |
No |
Yes |
Yes |
Hydroxychloroquine 200mg/day |
Lost to follow-up |
Zhou et al.1313 Zhou MY, Tan C. Comedonic discoid lupus erythematous. Scand J Rheumatol. 2019;48:331-2.
|
2019 |
54 |
M |
No |
2 years |
No |
Scalp |
Negative |
No |
Yes |
Yes |
Oral hydroxychloroquine and topical isotretinoin 0.01% |
Reduction of comedones in 3 months |
Cozzani et al.1414 Cozzani E, Herzum A, Burlando M, ParodiA. Comedonal variant of chronic cutaneous lupus erythematosus causing mutilation of the earlobe. JAAD Case Rep. 2020;6:843-4.
|
2020 |
45 |
F |
No |
1 year |
Yes |
Ears |
Negative |
No |
Yes |
No |
Photoprotection |
Stability |
Gaitibi et al.1515 El Gaitibi FA, Belcadi J, Ali SO, Znati K, Senouci K, Ismaili N. Comedonal plaque on the scalp. JAAD Case Rep. 2021;11:90-2.
|
2021 |
50 |
F |
- |
1 year |
No |
Scalp |
Negative |
No |
No |
No |
Not reported |
Not reported |
Chessé et al.1616 Chessé C, Fernández-Tapia M, Borzotta F. Lupus comedónico: presentación inusual de lupus cutáneo. Actas Dermosifiliogr. 2020;112:370-1.
|
2021 |
48 |
F |
- |
2 months |
- |
Mentum |
Positive
|
Yes |
Yes |
No |
Minocycline 100mg and topical tretinoin |
Good response |