Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?

Çelik, Havva Hilal Ayvaz; Kuyumcu, Mevlüt Serdar; Şirin, Fevziye Burcu; Cirit, Mehmet; Korkmaz, Selma; Erturan, İjlal; Çelik, Seda; Yıldırım, Mehmet

doi:10.1016/j.abd.2022.08.012

Havva Hilal Ayvaz Çelik ^** Corresponding author. E-mail:drhhilalayvaz@gmail.com (H.H. Ayvaz Çelik).

Approval of the final version of the manuscript

critical literature review

data collection

analysis and interpretation

effective participation in research orientation

ıntellectual participation in propaedeutic and/or therapeutic

management of studied cases

preparation and writing of the manuscript

manuscript has been read and approved by all the authors and has not been published

Department of Dermatology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey

https://orcid.org/0000-0002-6576-2431

Mevlüt Serdar Kuyumcu

Approval of the final version of the manuscript

critical literature review

data collection

analysis and interpretation

effective participation in research orientation

ıntellectual participation in propaedeutic and/or therapeutic

management of studied cases

manuscript critical review

statistical analysis

study conception and planning

manuscript has been read and approved by all the authors and has not been published

Department of Cardiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey

https://orcid.org/0000-0003-1934-5773

Fevziye Burcu Şirin

Approval of the final version of the manuscript

data collection

analysis and interpretation

manuscript critical review

study conception and planning

manuscript has been read and approved by all the authors and has not been published

Department of Biochemistry, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey

https://orcid.org/0000-0001-5304-1007

Mehmet Cirit

Data collection

analysis and interpretation

effective participation in research orientation

manuscript has been read and approved by all the authors and has not been published

Department of Dermatology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey

https://orcid.org/0000-0002-1775-8139

Selma Korkmaz

Manuscript critical review

manuscript has been read and approved by all the authors and has not been published

Department of Dermatology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey

https://orcid.org/0000-0003-3877-3976

İjlal Erturan

Manuscript critical review

manuscript has been read and approved by all the authors and has not been published

Department of Dermatology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey

https://orcid.org/0000-0002-0640-2292

Seda Çelik

Data collection

analysis and interpretation

manuscript has been read and approved by all the authors and has not been published

Department of Biochemistry, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey

https://orcid.org/0000-0002-0003-0651

Mehmet Yıldırım

Manuscript critical review

manuscript has been read and approved by all the authors and has not been published

Department of Dermatology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey

https://orcid.org/0000-0003-3373-9074

☆
Study conducted at the Dermatology and Biochemistry Departments of Suleyman Demirel University, Isparta, Turkey.

* Corresponding author. E-mail:drhhilalayvaz@gmail.com (H.H. Ayvaz Çelik).

Conflicts of interest

None declared.

	Patient group	Control group	p-value
	(n = 46)	(n = 43)
Age, years	40.3 ± 13.8	39.9 ± 11.6	0.890^a a Independent samples t-test.
BMI, kg/m²	25.9 ± 4.8	24.6 ± 3.2	0.154^a a Independent samples t-test.
Female, n (%)	19 (41.3)	18 (41.9)	0.958^b b Chi-Square.
Smoking, n (%)	25 (54.3)	20 (46.5)	0.460^b b Chi-Square.
Alcohol use, n (%)	9 (19.6)	13 (30.2)	0.244^b b Chi-Square.
Systolic blood pressure, mmHg	121.8 ± 18.7	115.1 ± 11.9	0.044 ^c c p < 0.05.
Diastolic blood pressure, mmHg	77.7 ± 9.7	74.0 ± 9.7	0.070^a a Independent samples t-test.
Pulse, per minute	79.2 ± 8.9	76.1 ± 6.5	0.067^a a Independent samples t-test.
Waist circumference, cm	94.8 ± 14.2	87.9 ± 7.2	0.005 ^c c p < 0.05.

	Patient group	Control group	p-value
	(n = 46)	(n = 43)
Glucose, mg/dL	110.1 ± 31.1	93.4 ± 14.2	0.021 ^a a p < 0.05, Mann-Whitney U-test.
Total cholesterol, mg/dL	191.3 ± 36.1	183.4 ± 36.5	0.365
Triglyceride, mg/dL	141.0 ± 67.0	102.6 ± 46.5	0.002 ^a a p < 0.05, Mann-Whitney U-test.
LDL, mg/dL	118.3 ± 27.4	110.8 ± 27.7	0.200
HDL, mg/dL	47.0 ± 13.1	51.8 ± 13.4	0.088
Hs-CRP, mg/L	4.1 ± 3.1	1.8 ± 2.1	0.002 ^a a p < 0.05, Mann-Whitney U-test.

	Patient group	Control group	p-value
	(n = 46)	(n = 43)
SCUBE-1 score	4.47 ± 2.40	2.66 ± 2.49	<0.001 ^a a p < 0.001, Mann-Whitney U-test.
Right CIMT	0.81 ± 0.07	0.75 ± 0.04	<0.001 ^a a p < 0.001, Mann-Whitney U-test.
Left CIMT	0.81 ± 0.08	0.74 ± 0.04	<0.001 ^a a p < 0.001, Mann-Whitney U-test.
Mean CIMT	0.81 ± 0.07	0.75 ± 0.04	<0.001 ^a a p < 0.001, Mann-Whitney U-test.

	PASI score ≤ 10	PASI score > 10	p-value
	(n = 16)	(n = 30)
SCUBE-1 score	4.80 ± 2.35	4.28 ± 2.44	0.487
Right CIMT	0.82 ± 0.07	0.81 ± 0.06	0.714
Left CIMT	0.84 ± 0.08	0.78 ± 0.14	0.138
Mean CIMT	0.83 ± 0.07	0.80 ± 0.08	0.153

	BMI	Duration of disease	Smoking	Systolic BP	Diastolic BP	Waist circumference	Total cholesterol	LDL	SCUBE1	CIMT	PASI
BMI
PC	1
Sig. (2-tailed)
Duration of disease
PC	0.130	1
Sig. (2-tailed)	0.389
Smoking
PC	0.013	−0.193	1
Sig. (2-tailed)	0.906	0.199
Systolic BP
PC	0.381^a a Correlation significant at 0.01 level (2-tailed).	−0.043	0.048	1
Sig. (2-tailed)	0.000^a a Correlation significant at 0.01 level (2-tailed).	0.778	0.658
Diastolic BP
PC	0.299^a a Correlation significant at 0.01 level (2-tailed).	0.171	−0.059	0.661^a a Correlation significant at 0.01 level (2-tailed).	1
Sig. (2-tailed)	0.004^a a Correlation significant at 0.01 level (2-tailed).	0.255	0.585	0.000^a a Correlation significant at 0.01 level (2-tailed).
Waist circumference
PC	0.676^a a Correlation significant at 0.01 level (2-tailed).	0.213	0.079	0.404^a a Correlation significant at 0.01 level (2-tailed).	0.330^a a Correlation significant at 0.01 level (2-tailed).	1
Sig. (2-tailed)	0.000^a a Correlation significant at 0.01 level (2-tailed).	0.155	0.464	0.000^a a Correlation significant at 0.01 level (2-tailed).	0.002^a a Correlation significant at 0.01 level (2-tailed).
Total cholesterol
PC	0.213^b b Correlation significant at 0.05 level (2-tailed).	0.028	0.010	0.198	0.097	0.166	1
Sig. (2-tailed)	0.045^b b Correlation significant at 0.05 level (2-tailed).	0.855	0.925	0.063	0.365	0.120
LDL
PC	0.222^b b Correlation significant at 0.05 level (2-tailed).	0.019	0.067	0.177	0.127	0.151	0.923^a a Correlation significant at 0.01 level (2-tailed).	1
Sig. (2-tailed)	0.037^b b Correlation significant at 0.05 level (2-tailed).	0.902	0.532	0.097	0.235	0.158	0.000^a a Correlation significant at 0.01 level (2-tailed).
SCUBE-1
PC	0.135	−0.204	0.091	0.294^a a Correlation significant at 0.01 level (2-tailed).	0.316^a a Correlation significant at 0.01 level (2-tailed).	0.205	0.156	0.203	1
Sig. (2-tailed)	0.208	0.175	0.398	0.005^a a Correlation significant at 0.01 level (2-tailed).	0.003^a a Correlation significant at 0.01 level (2-tailed).	0.053	0.146	0.057
CIMT
PC	−0.037	0.109	0.019	0.363^a a Correlation significant at 0.01 level (2-tailed).	0.272^a a Correlation significant at 0.01 level (2-tailed).	0.055	0.144	0.203	0.286^a a Correlation significant at 0.01 level (2-tailed).	1
Sig. (2-tailed)	0.727	0.472	0.856	0.000^a a Correlation significant at 0.01 level (2-tailed).	0.010^a a Correlation significant at 0.01 level (2-tailed).	0.611	0.179	0.057	0.007^a a Correlation significant at 0.01 level (2-tailed).
PASI
PC	0.171	0.130	0.198	0.079	0.097	0.010	−0.059	−0.193	0.028	0.144	1
Sig. (2-tailed)	0.255	0.389	0.063	0.464	0.365	0.925	0.585	0.199	0.855	0.357

	Univariable	p‒value	Multivariable	p-value
	OR (95% Cl)		OR (95% Cl)
Systolic blood pressure	0.970 (0.941‒1.000)	0.052
Waist circumference	0.947 (0.909‒0.986)	0.008 ^a a p < 0.05.	0.968 (0.919‒1.019)	0.212
Glucose level	0.965 (0.936‒0.994)	0.019 ^a a p < 0.05.	0.996 (0.969‒1.023)	0.764
Hs-CRP	0.733 (0.579‒0.927)	0.010 ^a a p < 0.05.	0.848 (0.649‒1.107)	0.225
Triglyceride	0.988 (0.980‒0.996)	0.005 ^a a p < 0.05.	0.992 (0.981‒1.003)	0.155
CIMT	0.960 (0.940‒0.981)	<0.001 ^b b p < 0.001.	0.965 (0.945‒0.976)	0.003 ^a a p < 0.05.
SCUBE-1	0.729 (0.598‒0.888)	0.002 ^a a p < 0.05.	0.828 (0.652‒1.051)	0.031 ^a a p < 0.05.

[1] ☆
Study conducted at the Dermatology and Biochemistry Departments of Suleyman Demirel University, Isparta, Turkey.

Brasil

Brasil

Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?^☆ ☆ Study conducted at the Dermatology and Biochemistry Departments of Suleyman Demirel University, Isparta, Turkey.

Abstract

Background

Objectives

Methods

Results

Study limitations

Conclusion

Brasil

Brasil

Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?☆ ☆ Study conducted at the Dermatology and Biochemistry Departments of Suleyman Demirel University, Isparta, Turkey.

Abstract

Background

Objectives

Methods

Results

Study limitations

Conclusion

Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?^☆ ☆ Study conducted at the Dermatology and Biochemistry Departments of Suleyman Demirel University, Isparta, Turkey.