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Tropical/Infectoparasitary Dermatology • An. Bras. Dermatol. 96 (2) • Mar-Apr 2021 • https://doi.org/10.1016/j.abd.2020.04.013   copy

Sporotrichosis refractory to conventional treatment: therapeutic success with potassium iodide☆ ☆ How to cite this article: Lyra MR, Sokoloski V, de Macedo PM, Azevedo ACP. Sporotrichosis refractory to conventional treatment: therapeutic success with potassium iodide. An Bras Dermatol. 2021;96:231-3. ,☆☆ ☆☆ Study conducted at the Laboratory of Clinical Research and Surveillance in Leishmaniasis, Instituto Nacional de Infectologia, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.

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Abstract

Sporotrichosis is a subcutaneous mycosis caused by dimorphic fungi of the genus Sporothrix. The authors report a case of fixed cutaneous sporotrichosis with therapeutic failure after 18 months of itraconazole and terbinafine associated with cryosurgery. The patient was cured after the introduction of saturated potassium iodide solution. Sporothrix brasiliensis was the identified species, presenting a susceptibility profile to itraconazole and terbinafine. This fact suggests that therapeutic failure is probably related to the host-fungus interaction rather than drug resistance. It is possible that the immunomodulatory action of the saturated potassium iodide solution may have played an important role in curing this patient.

KEYWORDS
Cryosurgery; Itraconazole; Potassium iodide; Sporothrix; Sporotrichosis

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