Effect of n-3 fatty acids in glycemic and lipid profiles, oxidative stress and total antioxidant capacity in patients with the metabolic syndrome

OBJECTIVE: Metabolic syndrome (MS) is a cluster of factors which favors the development of cardiovascular diseases. Previous studies have shown that polyunsaturated fatty acids (PUFAs) can improve some of these factors. This study aimed to evaluate the effect of fish oil on glucose and lipid profiles, oxidative stress and total antioxidant capacity (TRAP) in patients with MS. SUBJECTS AND METHODS: We conducted a clinical trial in 40 patients with the MS (20 controls and 20 patients receiving 3 g/day of PUFAs). SUBJECTS AND RESULTS: The group that received treatment showed a significant decrease in levels of triglycerides and increased in TRAP, but they had a significant increase in LDL, glucose and insulin resistance. CONCLUSION: We conclude that intake of fish oil resulted in decreased levels of triglycerides and increased the TRAP of patients with MS; however, increased LDL levels and insulin resistance, were observed.

Metabolic syndrome; serum lipids; fish oil; oxidative stress; insulin resistance