INTRODUCTION: Although the therapeutic effects of GnRH analogues (GnRHa) in central precocious puberty (CPP) have been established, clinical aspects may vary according to racial groups. OBJECTIVE AND METHODS: To describe the profile of 175 girls from Bahia, Brazil, treated with GnRHa for idiopathic CPP. RESULTS: The mulatto racial group predominated in the sample. The chronological age at puberty was 6.3 ± 0.1 years. At diagnosis, height was 2.2 ± 0.1 SD and body mass index (BMI) was 1.5 ± 0.1 SD (> 2 SD in 32%), this one, inversely associated with age at onset of puberty (R= -0.20, p= 0.008). At treatment, chronological and bone ages were 8.4±0.1 years and 10.3 ± 0.1 years, respectively. At the end of treatment (n= 52) age, BMI and height were 10.6 ± 0.1 years, 1.6 ± 0.2 SD and 1.9 ± 0.2 SD, respectively. CONCLUSION: Clinical presentation and evolution were similar to other studies, independently of racial characteristics. In this sample, treatment with GnRHa was not associated to significant weight gain.
Epidemiology; Puberty; Precocious puberty; Girls; GnRH analogues
