Effects of two dosages of continuous infusion of ketamine on the intraocular pressure (IOP) of 18 dogs, subjected to hypovolemia and anesthesia with desflurane were studied. Hypovolemia was induced in all dogs by withdrawal of 40ml of blood/kg of body weight. Initially, anesthesia was induced through face mask and then by tracheal intubation. After a delay of 30 minutes, for parameters stabilization, continuous infusion of ketamine was initiated. Dogs were randomly allotted in three groups (n =6): group I (control group) received continuous infusion of saline solution, group II received 100mug/kg/min of ketamine and group III received 200mug/kg/min of ketamine. IOP was measured by applanation tonometry. It was not possible to establish direct correlation between alterations of the mean arterial pressure and central venous pressure to those obtained to intraocular pressure. Desflurane did not affected values of intraocular pressure, however, direct action of ketamine was observed in all groups. It was possible to establish direct correlation between values of intraocular pressure and values of exhaled CO2.
desflurane; ketamine; hypovolemia; intraocular pressure; anesthesia
