Effects of robenacoxib on the minimum alveolar concentration of isofluorane in domestic felines

[Efeitos do robenacoxibe na concentração alveolar mínima do isofluorano em felinos domésticos]

ABSTRACT

Robenacoxib is a selective non-steroidal anti-inflammatory drug indicated for pain control in felines. The objective was to evaluate the effect of robenacoxib on the minimum alveolar concentration of isoflurane in cats. There were 30 cats that used one of the 3 treatments through therapy: GM - meloxicam (0.2 mg/kg), GR - robenacoxib (2 mg/kg) or GC - 0.9% saline solution (0.1 ml/kg) kg). We waited 30 minutes, and the animals were induced to general anesthesia with isoflurane in an induction box, intubated and anesthetized with 1.5 V% isoflurane. All animals were secured to a supramaximal nociceptive stimulus (tail pinch). Positive response was defined as proposed movement of the head and/or limbs. The method for determining MAC was up and down to Dixon, and calculation of the average of crossover values according to Monteiro (2016). The mean and standard deviation of ISO_MAC was 2.10±0.15%, 1.95±0.14%, and 1.7±0.15% in GC, GM, and GR, respectively. Robenacoxib reduced to 19.1% and 12.8% ISO_MAC when compared to a control group and a group that received meloxicam, respectively.

Keywords:
cats; robenacoxib; CAM; NSAIDs