ABSTRACT
The aim of this study was to determine changes in the carnitine and amino acid profile of goats with clinical pregnancy toxemia. The study included a total of 40 Aleppo breed goats, 20 with clinical pregnancy toxemia and 20 healthy goats. The goats with low glucose level and BHBA of 1.6-5mmol/L formed the group with clinical pregnancy toxemia, and goats with high glucose level and BHBA <0.8mmol/L formed the control group. Carnitine and amino acid profiles were determined in the groups. The results showed that the serum BHBA level was significantly higher, and the glucose level was lower in the clinical pregnancy toxemia group (p<0.001). From the serum amino acid profiles, the levels of Methyl Glutaryl, Valine, Methionine, Phenylalanine, Tyrosine, Asparagine, Arginine, Glutamic Acid, Alanine and Ornithine were determined to be statistically significantly low in the pregnancy toxemia group (p<0.01), and lysine was determined to be significantly high (p<0.01). It was determined that all serum carnitine profiles, except Decenoylcarnitine and Propionylcarnitine, were higher in goats with clinical pregnancy toxemia (p<0.05). In conclusion, it was concluded that these two profiles can be used as biomarkers in the diagnosis of pregnancy toxemia.
Keywords:
pregnancy toxemia; amino acid; carnitine; goat
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