Fecal microbiota characterization in a swine model undergoing experimental bariatric surgery sand clock with gastro-jejunal bypass

[Caracterização da microbiota fecal em modelo suíno submetido à cirurgia bariátrica experimental relógio de areia com bypass gastrojejunal]

ABSTRACT

Bariatric surgery induces a variety of changes, including changes in the composition of the gut microbiota. The investigation evaluated the effect of the experimental gastrojejunal bypass bariatric surgery hourglass (EBSSC G-YB) on the fecal bacterial microbiota in obese Landrace pigs. Twelve six-month-old animals were used, which were supplemented with energy from 2.5 months for a period of 120 days, enough time to reach the condition. Subsequently, they were intervened with the EBSSC G-YB and the changes in the microbiota were characterized, comparing an experimental group with two control groups in a period of 30 days. The result was that the microbiota of the three groups showed Proteobacteria, Firmicutes and Bacteroidetes as the ones with the highest relative abundance, however, at the end of the experiment a difference is highlighted, where the Phylum Spirochaetes was constant and more frequently in the experimental group, while for control groups 1 and 2 it was the Phylum Tenericutes. Although the differences were not significant, qualitatively there was greater diversity in the experimental group, with greater abundance of Escherichia-Shigella and Pseudohongiella, which may be useful as quantifiable biomarkers of weight loss in future research.

Keywords:
bariatric surgery; gastrointestinal microbiome; metabolic surgery; microbiota; obesity