Through physical examination, blood gas and the electrocardiographic effects of salbutamol and fenoterol, administered by inhalation in dogs was assessed. Twelve dogs were distributed into two groups: EF group animals received a fenoterol dose of 2 drops/5kg bodyweight, diluted in sodium chloride 0.9% inhalation device and animals in the SA group received salbutamol through aerosol feeder at a dose of 100µg. Rectal temperature (RT), heart rate (HR), respiratory rate (RR), systolic blood pressure (SBP), blood gas and electrocardiogram before and after 30min., 2h and 6 h after drug were evaluated. Mild cardiac stimulation occurred in SA group animals 2 hours after its administration compared to the control group, and tremors were predominant in these animals. A decrease in SBP and an increase in RR were observed in both animal groups and no significant alteration of the T wave in the electrocardiogram and blood gas analysis in both groups were observed. The fenoterol caused less cardiac pacing and shivering compared to salbutamol, which was more secure. However, there was more ease, lower cost and less time spent in the administration of salbutamol administered through metered-dose inhaler compared to fenoterol nebulization.
dog; fenoterol; salbutamol; inhalation
