Influence of the dilution method on the intraocular duration of C<sub>3</sub>F<sub>8</sub> in vitrectomy for macular hole: a randomized clinical trial

Pinto, Alexandre Paashaus da Costa; Soares, Daniel Tenório Camelo; Costa, Marília Rocha; Lira, Rodrigo Pessoa Cavalcanti

doi:10.5935/0004-2749.2022-0336

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ORIGINAL ARTICLE • Arq. Bras. Oftalmol. 87 (2) • 2024 • https://doi.org/10.5935/0004-2749.2022-0336 copy

Influence of the dilution method on the intraocular duration of C₃F₈ in vitrectomy for macular hole: a randomized clinical trial

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Purpose:

To compare the injection of small amounts of undiluted C₃F₈ with the traditional gas injection in vitrectomy for macular hole treatment.

Methods:

This clinical trial included 26 individuals divided into two groups. Group 1 received an intravitreal injection of 0.9-1.0 mL of 100% C₃F₈, and Group 2 received 15-20 mL of 20% C₃F₈.

Results:

The median intraocular gas duration was 31 days in Group 1 and 34 in Group 2. The median letter gains in corrected distance visual acuity for the 26^th postoperative week were 20 letters in Group 1 and 12.5 in Group 2. The median intraocular pressure was normal in both groups. Primary anatomical success was 11/13 in both groups.

Conclusions:

The use of C₃F₈ gas in a small undiluted volume is an alternative that slightly reduces the duration of the gas without negatively affecting the anatomical and visual response.

Keywords:
Retinal perforations/surgery; Vitrectomy; Sulfur hexafluoride/administration & dosage; Fluorocarbons/administration & dosage; Gases; Tomography; optical coherence

	Group 1 0.9-1.0 mL 100% C3F8	Group 2 15-20 mL 20% C3F8	p-value
Age (years) ^a	72 ± 4	70 ± 6	0.397^c c = independent samples t-test;
Female	7/13	8/13	0.691^d d = chi-square test;
Right eye	7/13	6/13	0.695^d d = chi-square test;
Macular hole size (μm) ^a a = mean ± standard deviation;	333 ± 107	330 ± 123	0.952^c c = independent samples t-test;
Macular hole classification:			0.895^d d = chi-square test;
Small (<250 μm)	4/13	5/13
Medium (250-400 μm)	5/13	4/13
Large (>400 μm)	4/13	4/13
Axial length (mm)^a a = mean ± standard deviation;	24.01 ± 0.81	24.04 ± 0.61	0.918^c c = independent samples t-test;
Vitreous cavity volume (mL)^a a = mean ± standard deviation;	5.21 ± 0.58	5.23 ± 0.43	0.918^c c = independent samples t-test;
Concentration of intravitreal gas (%)^a a = mean ± standard deviation;	15.1 ± 0.6	15.3 ± 0.3	0.341^c c = independent samples t-test;
Preoperative CDVA (letters)^b b = median (interquartile range);	43 (15)	43 (10)	0.342^e e = Mann-Whitney U-test. CDVA= corrected distance visual acuity (based on ETDRS charts); IOP = intraocular pressure.
Preoperative CDVA (Snellen)	± 20/160	± 20/160
Preoperative IOP (mmHg)^b b = median (interquartile range);	15 (1)	14 (2)	0.254^e e = Mann-Whitney U-test. CDVA= corrected distance visual acuity (based on ETDRS charts); IOP = intraocular pressure.

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[1] Disclosure of potential conflicts of interest: None of the authors have any potential conflicts of interest to disclose.

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Influence of the dilution method on the intraocular duration of C3F8 in vitrectomy for macular hole: a randomized clinical trial

ABSTRACT

Purpose:

Methods:

Results:

Conclusions:

Influence of the dilution method on the intraocular duration of C₃F₈ in vitrectomy for macular hole: a randomized clinical trial