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The effects of posterior subtenon injection of corticosteroids in patients with uveitis

PURPOSE: To determine the effects of posterior subtenon steroid injection (PSSI) according to intraocular pressure and visual acuity, in patients with uveitis. METHODS: Eighteen patients with diagnosis of uveitis were analized and submitted to posterior subtenon steroid injection of triancinolone acetonide (Kenalog® 40mg - 9 patients, 14 injections) or of methyl- prednisolone acetate (Depomedrol® 40mg - 9 patients, 15 in- jections) for the treatment of chronic eye inflammation or cystoid macular edema. RESULTS: Final visual acuity improved in 92% of the patients after the first injection; 50% improved one line, and 42% improved at least three lines. The mean time for improvement was three weeks. Increase of IOP occurred in 44% of the patients (8 patients), who showed a mean intraocular pressure of 31 mmHg and a range of 21 to 38 mmHg. It was more frequent among young patients, and in the Kenalog® group, with onset after 2.5 weeks on average. CONCLUSION: A subtenoninjection of corticosteroids appears to be an effective treatment for decreased vision associated with some types of uveitis, such as intermediate uveitis, Behçet's disease, Vogt-Koyanagi-Harada syndrome, retinal vasculitis and rheumatoid arthritis. However, it may contribute to increase in intraocular pressure in some cases, specially in children and young patients.

Uveitis; Injections; Adrenal cortex hormones; Visual acuity; Glaucoma; Intraocular pressure; Cystoid macular edema; Triamcinolone


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