Combined
Biological &
Clinical Therapy |
NK1R antagonists Lanepitant and
Befetupitant for corneal neovascularization |
Reduction of corneal hemangiogenesis, lymphangiogenesis,
and leukocyte infiltration |
Bignami et al., 2014(185185 Bignami F, Giacomini C, Lorusso A, Aramini A, Rama P, Ferrari G. NK1 receptor antagonists as a new treatment for corneal neovascularization. Invest Ophthalmol Vis Sci. 2014;55(10):6783-94.)
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Contact lenses for the culture and delivery
of corneal epithelial cells for the treatment
of limbal stem cell deficiency |
Reconstruction of the recipient corneal surface |
Brown et al., 2014(186186 Brown KD, Low S, Mariappan I, Abberton KM, Short R, Zhang H, et al. Plasma polymer-coated contact lenses for the culture and transfer of corneal epithelial cells in the treatment of limbal stem cell deficiency. Tissue Eng Part A. 2014;20(3-4):646-55.)
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| Topical AMA0526 after corneal trauma |
Inhibition of angiogenesis in vitro, reduction of
corneal opacity, and neovascularization |
Sijnave et al., 2015(187187 Sijnave D, Van Bergen T, Castermans K, Kindt N, Vandewalle E, Stassen JM, et al. Inhibition of Rho-associated kinase prevents pathological wound healing and neovascularization after corneal trauma. Cornea. 2015;34(9):1120-9.)
|
Topical applied cell-permeable FK506BP
on corneal alkali burn injury |
Corneal opacity and corneal
neovascularization were significantly decreased |
Kim et al., 2015(188188 Kim DW, Lee SH, Shin MJ, Kim K, Ku SK, Youn JK, et al. PEP-1-FK506BP inhibits alkali burn-induced corneal inflammation on the rat model of corneal alkali injury. BMB Rep. 2015;48(11):618-23.)
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| Topical β-1,3-glucan in corneal alkali burn |
Epithelial wound healing in vitro and
suppression of acute inflammatory reaction |
Choi et al., 2013(189189 Choi JA, Oh TH, Choi JS, Chang DJ, Joo CK. Impact of beta-1,3-glucan isolated from Euglena gracilis on corneal epithelial cell migration and on wound healing in a rat alkali burn model. Curr Eye Res. 2013;38(12):1207-13.)
|
Downregulation of vimentin by pharmacological
agent withaferin A in corneal alkali injury |
Vimentin deficiency alters the fibrotic response to corneal
alkali injury and instead engages a reparative healing
mechanism to restore corneal clarity |
Bargagna-Mohan
et al., 2012(190190 Bargagna-Mohan P, Paranthan RR, Hamza A, Zhan CG, Lee DM, Kim KB, et al. Corneal antifibrotic switch identified in genetic and pharmacological deficiency of vimentin. J Biol Chem. 2012; 287(2):989-1006.)
|
Inhibitory oligonucleotides of miR-206,
miR-206-I, intrastromally injected into alkali-burned
corneas. The possible binding of miR-206 on its
molecular target Cx43 was assessed |
Ameliorated inflammatory responses both in vivo
and in vitro. Cx43 was directly targeted by miR-206 |
Li et al., 2015(191191 Li X, Zhou H, Tang W, Guo Q, Zhang Y. Transient downregulation of microRNA-206 protects alkali burn injury in mouse cornea by regulating connexin 43. Int J Clin Exp Pathol. 2015;8(3):2719-27.)
|
Injection of a naked plasmid expressing green
fluorescent protein (GFP; pCMV-GFP) into an
unwounded mouse corneal stroma. Injection of
pCMV-GFP or plasmids expressing small hairpin
RNA in the corneal wound injury model |
In the corneal wound injury model, the GFP-positive
cells demonstrated extensive dendritic-like processes that
extended to adjacent cells, whereas the vimentin knockdown
model showed significantly reduced corneal opacity |
Das et al., 2014(192192 Das SK, Gupta I, Cho YK, Zhang X, Uehara H, Muddana SM, et al. Vimentin knockdown decreases corneal opacity. Invest Ophthalmol Vis Sci. 2014;55(7):4030-40.)
|
Application of angiogenin eye drops in
neovascularization and corneal opacity |
Reduction of the inflammatory response
induced by TNF-α or LPS |
Lee et al., 2016(193193 Lee SH, Kim KW, Joo K, Kim JC. Angiogenin ameliorates corneal opacity and neovascularization via regulating immune response in corneal fibroblasts. BMC Ophthalmol. 2016;16:57.)
|
Keratocytes in culture and within intact
normal and diseased tissue were induced
to produce collagen type II upon treatment
with TGFβ3 and dexamethasone |
Collagen type II deposition and a threefold
increase in corneal hardness and elasticity |
Greene et al., 2016(194194 Greene CA, Green CR, Dickinson ME, Johnson V, Sherwin T. Keratocytes are induced to produce collagen type II: a new strategy for in vivo corneal matrix regeneration. Exp Cell Res. 2016;347(1):241-9.)
|
Fresh isolated omental cells were injected
subconjunctivally in limbal corneal alkali injury |
Reduction of corneal neovascularization
and neutrophil infiltration |
Bu et al., 2014(195195 Bu P, Vin AP, Sethupathi P, Ambrecht LA, Zhai Y, Nikolic N, et al. Effects of activated omental cells on rat limbal corneal alkali injury. Exp Eye Res. 2014;121:143-6.)
|
Deep corneal neovessels treated with
intrastromal injections of bevacizumab |
Complete regression of neovessels in 16 patients, partial
regression in 6 patients, and reduced opacity and
improved visual acuity in 5 patients |
Sarah et al., 2016(196196 Sarah B, Ibtissam H, Mohammed B, Hasna S, Abdekhakuk M. Intrastromal injection of bevacizumab in the management of corneal neovascularization: about 25 eyes. J Ophthalmol. 2016;2016:6084270.)
|
Combined
Biological &
Surgical Therapy |
Allogeneic limbal mesenchymal stem cell
therapy after severe corneal chemical burn |
Reduction of corneal opacity, neovascularization, and
corneal fluorescein staining |
Acar et al., 2015(197197 Acar U, Pinarli FA, Acar DE, Beyazyldiz E, Sobaci G, Ozgermen BB, et al. Effect of allogeneic limbal mesenchymal stem cell therapy in corneal healing: role of administration route. Ophthalmic Res. 2015;53(2):82-9.)
|
Autologous or allogenic cultivated limbal
stem cell transplantation using a standardized
protocol free from xenogenic products |
Reduction in corneal neovascularization |
Zakaria et al., 2014(198198 Zakaria N, Possemiers T, Dhubhghaill SN, Leysen I, Rozema J, Koppen C, et al. Results of a phase I/II clinical trial: standardized, non-xenogenic, cultivated limbal stem cell transplantation. J Transl Med. 2014;12:58.)
|
The transplantation of CECs in combination
with the selective ROCK inhibitor Y-27632
in corneal endothelial dysfunction |
Endothelium with a monolayer hexagonal cell
shape with a normal expression of function-related
markers; recovery of corneal transparency |
Okumura et al., 2012(199199 Okumura N, Koizumi N, Ueno M, Sakamoto Y, Takahashi H, Tsuchiya H, et al. ROCK inhibitor converts corneal endothelial cells into a phenotype capable of regenerating in vivo endothelial tissue. Am J Pathol. 2012;181(1):268-77.),
Kinoshita et al.,(158158 Kinoshita S, Koizumi N, Ueno M, Okumura N, Imai K, Tanaka H, Yamamoto L, et al. Injection of cultured cells with a ROCK inhibitor for bullous keratopathy. N Engl J Med. 2018;378(11):995-1003.)
|
Autologous and allogeneic limbal epithelial cells
cultivated on amniotic membranes and transplanted
in cases of limbal stem cell deficiency |
Improvement in corneal epithelium
quality, with subsequent improvement
in symptoms, quality of life, and vision |
Ramirez et al., 2015(200200 Ramírez BE, Sanchez A, Herreras JM, Fernández I, Gárcia-Sancho J, Nieto-Miguel T, et al. Stem cell therapy for corneal epithelium regeneration following good manufacturing and clinical procedures. Biomed Res Int. 2015;2015:408495.)
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