Purpose: To analyze the influence of cicloplegia on latanoprost ocular hypotensive effect in normal subjects. Patients, material and methods: The study included 17 normal volunteers without previous ocular diseases, trauma or surgeries. One drop of 0.005% latanoprost was given to both eyes and after 20 minutes one drop of 1% ciclopentolate was instilled only in right eyes. Intraocular pressure (IOP) was measured using Goldmann tonometry in both eyes at the following time points: before latanoprost, after 20 minutes, 1 hour and 20 minutes, 3 hours and 20 minutes and 4 hours and 20 minutes. IOP was compared between right and left eyes (Wilcoxon test) and among the different times of study for each eye (Friedman test). Percentual IOP change from initial reading was calculated and compared between OD and OS. Results: No statistical differences were detected regarding the initial, 20 minute, 1 hour and 20 minute and 3 hours and 20 minute measurements. For the 4 hours and 20 minute readings the comparison of IOP levels and their percentual change between OD and OS showed statistical differences. The mean IOP was lower in OD (IOPOD = 10.9 ± 2.2; IOPOS = 11.8 ± 2.2; p = 0.009). The right eyes showed statistically higher IOP percentual reduction than left eyes (delta%OD = -28.1±7.4; delta%OS = -21.6 ± 9.6; p = 0.006). Conclusion: The results showed a higher short-term latanoprost IOP reduction in eyes treated with ciclopento-late 1%, as compared to the contralateral eyes.
Prostaglandins; Intraocular pressure; Mydriatics
