Optical coherence tomography angiography artifactual choroidal neovascularization in optic disc pit maculopathy

Artefato de neovascularização de coroide na angiografia por tomografia de coerência óptica em pit de disco óptico

ABSTRACT

This case report describes a 19-year-old Caucasian man presented with decreased visual acuity in the right eye for 3 months. Dilated funds exam revealed optic disk pit associated with serous macular detachment. Optical coherence tomography identified communication between the optic disk pit and the macular serous detachment, and optical coherence tomography angiography displayed a subfoveal area suggestive of subfoveal choroidal neovascularization. However, there was no evidence of leakage in the fluorescein angiogram and no evidence of choroidal neovascularization in optical coherence tomography in the area corresponding to the suspicious subfoveal choroidal neovascularization. The patient underwent 23-gauge pars plana vitrectomy in the right eye. Six weeks after surgery, multimodal imaging was repeated and there was near-complete resorption of the subretinal fluid. Optical coherence tomography angiography signal superimposed on optical coherence tomography B-scan also demonstrated normal choriocapillaris signal throughout the macula. In conclusion, optical coherence tomography angiography may produce artifacts in optic disk pit maculopathy that simulate choroidal neovascularization.

Keywords:
Optic disk; Tomography, optical coherence; Fluorescein angiography; Vitrectomy; Retinal detachment; Artifacts

RESUMO

O presente estudo relatou o caso de um homem caucasiano de 19 anos com diminuição da acuidade visual no olho direito há 3 meses. Na fundoscopia havia um pit de papila associado ao descolamento seroso macular. A tomografia de coerência óptica identificou uma comunicação entre o pit e o descolamento seroso e a angiografia por tomografia de coerência óptica demonstrou uma área subfoveal sugestiva de membrana neovascular sub-retiniana. No entanto, não houve evidência de vazamento na angiofluoresceínografia com contraste e nem de membrana neovascular sub-retiniana na tomografia de coerência óptica na área suspeita. O paciente foi submetido a vitrectomia pars plana 23-gauge no olho direito. Seis semanas após a cirurgia, os exames foram repetidos e houve reabsorção quase completa do líquido sub-retiniano. O sinal da angiografia por tomografia de coerência óptica sobreposto à tomografia de coerência óptica B-scan era normal na região da mácula. Em conclusão, a angiografia por tomografia de coerência óptica pode produzir artefatos em maculopatia secundária a pit de papila que simulam uma membrana neovascular sub-retiniana.

Descritores:
Disco óptico; Tomografia de coerência óptica; Angiofluoresceínografia; Vitrectomia; Descolamento retiniano; Artefatos

INTRODUCTION

Optical coherence tomography angiography (OCTA) is a novel technology that generates volumetric angiography images with applicability for the diagnosis and follow-up of a wide range of retinal diseases. However, OCTA image artifacts can alter vascular appearance, leading to false clinical interpretations¹. Optic disc pit (ODP) is a rare clinical entity characterized by a congenital cavity of the optic nerve head². The disease may be complicated by serous macular detachment, causing progressive visual loss. ODP may be rarely asso ciated with peripapillary choroidal neovascularization (CNV)³. We report a case of ODP maculopathy in which preoperative OCTA revea led artifactual subfoveal CNV and postoperative OCTA was normal.

CASE REPORT

A 19-year-old caucasian, otherwise healthy man presented with decreased visual acuity in the right eye for 3 months. Best-corrected visual acuity (BCVA) was 20/60 in the right eye and 20/20 in the left eye. Intraocular pressures were 12 mmHg and 10 mmHg in the right and left eyes, respectively. Pupillary reflexes were normal in both eyes. Anterior segment slit-lamp exam was unremarkable in both eyes. Dilated funds exam revealed ODP associated with serous macular detachment in the right eye. Dilated funds exam of the left eye was normal. Multimodal imaging was performed (OCTA; RTVueXR Avanti device; Optovue Inc.; Fremont, CA, USA. Retinography; Topcon Retinal Camera TRC 50DX; Topcon Corp., Tokyo, Japan. Fluorescein angiography; Heidelberg HRA Spectralis/HRA2; Heidelberg Engi neering, Heidelberg, Germany) (Figure 1). OCT identified communication between the optic disc and the macular serous detachment. OCTA displayed a small, discrete subfoveal area suggestive of CNV surrounded by an area of relatively decreased choriocapillaris vessel density (Figure 1 E). OCTA signal superimposed on OCT B-scan de monstrated choriocapillaris detection underneath the center of the fovea, surrounded by areas of no detection on each side (Figure 1 F) There was no evidence of leakage in the fluorescein angiogram and no evidence of CNV on OCT in the area corresponding to the suspicious subfoveal CNV.

Figure 1
Preoperative multimodal imaging of the right eye: optic disc pit maculopathy in a 19-year-old man. A) Color image shows an optic disk pit associated with serous macular detachment. B) Fluorescein angiography. C) En-face OCT (superficial retina). D) Fundus autofluorescence. E) OCTA: image suggesting CNV (white arrow). F) OCT B-scan indicating the presence of communication between the optic nerve and serous retinal detachment. G) OCT showing subretinal fluid (yellow arrow).

The patient underwent 23-gauge pars plana vitrectomy in the right eye. Triamcinolone-assisted posterior hyaloid detachment, as well as fluid-air exchange, was performed. No laser or peeling was performed during the surgery and air was used as the vitreous substitute. Six weeks after surgery, multimodal imaging was repeated (Figure 2). There was subtotal resorption of the subretinal fluid. BCVA improved to 20/20 in the right eye. OCTA demonstrated normal choriocapillaris signal throughout the macula (Figure 2 E). OCTA signal superimposed on OCT B-scan also demonstrated normal choriocapillaris signal throughout the macula (Figure 2 F).

Figure 2
Postoperative multimodal imaging of the right eye: resolution of optic disc pit maculopathy in a 19-year-old man. A) Color image. B) Fluorescein angiography. C) En-face OCT (superficial retina). D) Fundus autofluorescence. E) OCTA: disappearance of suspicious CNV image. F and G) OCT B-scan indicating near-complete absorption of subretinal fluid.

DISCUSSION

OCTA images can produce both positive and negative artifacts, which are important to recognize when interpreting clinical images. For instance, reflection artifacts may project superficial vessels into deeper layers and shadowing or eye movement artifacts may create areas devoid of vessels¹.

We presented a case of a young patient diagnosed with ODP maculopathy whose preoperative OCTA suggested subfoveal CNV. Note that OCTA displayed a ring of relatively decreased choriocapillaris signal surrounding a small, subfoveal area of relatively increased choriocapillaris signal (Figure 1 E). The same phenomenon was present in the OCTA signal superimposed on the OCT B-scan (Figure 1 F). However, fluorescein angiogram and OCT did not demonstrate any signs of CNV in the same area, which suggests an artifactual lesion.

The patient was scheduled for PPV, which caused near-complete resolution of subretinal fluid 6 weeks postoperatively. Postoperative OCTA revealed normal choriocapillaris, confirming the artifactual na ture of the suspected subfoveal CNV. Possible mechanisms for the abovementioned artifactual CNV include light scattering by the elevated retina and/or presence of subretinal fluid.

In conclusion, optical coherence tomography angiography may produce artifacts in optic disc pit maculopathy that simulate choroidal neovascularization. Multimodal imaging is important to accurately interpret unusual optical coherence tomography angiography findings.

• Funding: No specific financial support was available for this study.

REFERENCES

• ¹
  Spaide RF, Fujimoto JG, Waheed NK. Image Artifacts in Optical Coherence Tomography Angiography. Retina. 2015;35(11):2163-80.
• ²
  Georgalas I, Ladas I, Georgopouls G, Petrou P. Optic disc pit: a review. Arch Clin Exp Ophthalmol. 2011;249(8):1113-22.
• ³
  Borodic GE, Gragoudas ES, Edward WO, Brockhurst RJ. Peripapillary subretinal neovascularization and serous macular detachment. Association with congenital optic nerve pits. Arch Ophthalmol. 1984;102(2):229-31.

Publication Dates

• Publication in this collection
  Jul-Aug 2017

History

• Received
  10 Jan 2017
• Accepted
  07 Mar 2017