Toxoplasmose ocular congênita em irmãos consecutivos

Silva, Milena Simões F.; Yamamoto, Aparecida Y.; Carvalheiro, Cristina G.; Grigg, Michael E.; Medeiros, Ana Leonor A. de; Mussi-Pinhata, Marisa M.; Furtado, João M.

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LETTERS • Arq. Bras. Oftalmol. 85 (6) • 2022 • https://doi.org/10.5935/0004-2749.20220079 copiar

Toxoplasmose ocular congênita em irmãos consecutivos

Autoria SCIMAGO INSTITUTIONS RANKINGS

RESUMO

A infecção pelo Toxoplasma gondii pode causar manifestações oculares tanto após a sua forma congênita quanto a sua forma adquirida. Reportamos aqui dois casos de toxoplasmose congênita sintomática com envolvimento ocular em irmãos não gêmeos, com intervalo de 2 anos entre gestações. A transmissão vertical da toxoplasmose em gestações sucessivas, outrora considerada impossível, é um evento plausível mesmo em indivíduos imunocompetentes.

Descritores:
Toxoplasmose ocular/congênita; Toxoplasmose ocular/genética; Toxoplasmose congênita; Toxoplasma gondii ; Uveite

Peptide^a a= peptides are named as follows: “6” or “7,” peptides derived from the genotypic markers GRA6 or GRA7; “I/III” or “II,” the archetypal parasite strain from which the peptide was derived; and “d,” a truncated diagnostic peptide;	Mother	Child 1	Child 2	Cutoff^d d= calculated from the mean values + 2 standard deviations obtained from 41 healthy pregnant women who were seronegative for toxoplasmosis.
6 I/III	1.59	2.07	1.15	2,68
d6 I/III	0.94	1.24	0.98	1,53
6 II	4.42^* *= The values refer to the mean optical density index obtained for each sample; positive values are marked with an asterisk.	4.81^* *= The values refer to the mean optical density index obtained for each sample; positive values are marked with an asterisk.	3.28^* *= The values refer to the mean optical density index obtained for each sample; positive values are marked with an asterisk.	1,47
7 II	5.41^* *= The values refer to the mean optical density index obtained for each sample; positive values are marked with an asterisk.	3.28^* *= The values refer to the mean optical density index obtained for each sample; positive values are marked with an asterisk.	1.17	1,58
SAG1^b b= SAG1 indicates the presence of anti-Toxoplasma antibodies;	6.57^* *= The values refer to the mean optical density index obtained for each sample; positive values are marked with an asterisk.	7.28^* *= The values refer to the mean optical density index obtained for each sample; positive values are marked with an asterisk.	6.52^* *= The values refer to the mean optical density index obtained for each sample; positive values are marked with an asterisk.	0,88
Toxoplasma serotype ^c c= infections by type I/III strains produce antibodies that react with either or both 6 I/III and d6 I/III peptides. Infections by the type II strains produce antibodies that react with either or both 6 II and 7 II peptides. Atypical serotypes react with both type I/III and II peptides or do not react with any peptide;	II	II	II	-

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[1] Corresponding author: João M. Furtado. E-mail: furtadojm@gmail.com