Purpose: To evaluate the success in reducing intraocular pressure (IOP) using trabeculectomy without antifibro-blastic drugs and trabeculectomy with adjunct 5-fluorou-racil or mitomycin-C as well as to assess if the time of mito-mycin-C exposure modifies this success rate. Methods: 171 consecutive eyes operated between January 1989 and March 1998 were retrospectively analyzed, 16 eyes having been submitted to simple trabeculectomy, 38 eyes to trabeculectomy and postoperative application of 5-fluorouracil and 117 eyes to trabeculectomy and intra-operative application of mitomycin-C. Results: There was a significant reduction in IOP with the use of antifibroblastic drugs (p<0.05). Exposure time to mitomycin-C did not present a statistically significant difference (p>0.05). Conclusions: Trabeculectomy associated with antifibro-blastic drugs significantly reduces IOP and promotes short-term stability.
Trabeculectomy; 5-Fluoruracil; Mitomycin-C
