Congenital ocular toxoplasmosis in consecutive siblings

Silva, Milena Simões F.; Yamamoto, Aparecida Y.; Carvalheiro, Cristina G.; Grigg, Michael E.; Medeiros, Ana Leonor A. de; Mussi-Pinhata, Marisa M.; Furtado, João M.

doi:10.5935/0004-2749.20220079

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LETTERS • Arq. Bras. Oftalmol. 85 (6) • 2022 • https://doi.org/10.5935/0004-2749.20220079 copy

Congenital ocular toxoplasmosis in consecutive siblings

Toxoplasmose ocular congênita em irmãos consecutivos

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Toxoplasma gondii infection can cause ocular manifestations after acquired and congenital disease. We report two cases of symptomatic congenital toxoplasmosis with ocular involvement in non-twin siblings, with a 2-year interval between pregnancies. Vertical transmission of toxoplasmosis in successive pregnancies, which was once considered impossible, is now found to be plausible even in immunocompetent subjects.

Keywords:
Toxoplasmosis, ocular/congenital; Toxoplasmosis, ocular/genetics; Toxoplasmosis, congenital; Toxoplasma gondii ; Uveitis

Peptide^a a= peptides are named as follows: “6” or “7,” peptides derived from the genotypic markers GRA6 or GRA7; “I/III” or “II,” the archetypal parasite strain from which the peptide was derived; and “d,” a truncated diagnostic peptide;	Mother	Child 1	Child 2	Cutoff^d d= calculated from the mean values + 2 standard deviations obtained from 41 healthy pregnant women who were seronegative for toxoplasmosis.
6 I/III	1.59	2.07	1.15	2,68
d6 I/III	0.94	1.24	0.98	1,53
6 II	4.42^* *= The values refer to the mean optical density index obtained for each sample; positive values are marked with an asterisk.	4.81^* *= The values refer to the mean optical density index obtained for each sample; positive values are marked with an asterisk.	3.28^* *= The values refer to the mean optical density index obtained for each sample; positive values are marked with an asterisk.	1,47
7 II	5.41^* *= The values refer to the mean optical density index obtained for each sample; positive values are marked with an asterisk.	3.28^* *= The values refer to the mean optical density index obtained for each sample; positive values are marked with an asterisk.	1.17	1,58
SAG1^b b= SAG1 indicates the presence of anti-Toxoplasma antibodies;	6.57^* *= The values refer to the mean optical density index obtained for each sample; positive values are marked with an asterisk.	7.28^* *= The values refer to the mean optical density index obtained for each sample; positive values are marked with an asterisk.	6.52^* *= The values refer to the mean optical density index obtained for each sample; positive values are marked with an asterisk.	0,88
Toxoplasma serotype ^c c= infections by type I/III strains produce antibodies that react with either or both 6 I/III and d6 I/III peptides. Infections by the type II strains produce antibodies that react with either or both 6 II and 7 II peptides. Atypical serotypes react with both type I/III and II peptides or do not react with any peptide;	II	II	II	-

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[1] Corresponding author: João M. Furtado. E-mail: furtadojm@gmail.com