Cyanoacrylate derivates have been used as surgical adhesives, like ethyl-cyanoacrylate(Super-Bonder) and buthyl-cyanoacrylate(Histoacryl) for many years.In this study, the histotoxicity and binding ability of Super-Bonder and Histoacryl were compared.32 rats were operated, and distributed in 3 groups :A, B and C. Each group was subdivived in 2 subgroups , to be studied after 7 and 14 days postoperatory .2 longitudinals incisions with 3 centimetre in lenght, were done in each animal. The left incision was sutured with Nylon 5.0 (group C) as controls and the right incision was sutured with ethil-cyanoacrylate (group A) and buthil-cyanoacrylaty (group B). Our results allowed us to clearly study tissue acute inflammation, the presence of dehiscense and fibrosis that eventualy occured. Throughtout the study period, there was no statistical difference in the viability of buthyl-cyanoacrylate and Nylon. Buthyl-cyanoacrylate showed mild acute inflammation, and mild foreign body giant cell reaction, and had minimal histotoxic effect when compared with ethyl-cyanoacrylate. There was non intolerance to the adhesive nor dehiscense. This method is easy and without side effects on the skin.
Cyanoacrylates; Rats; Adhesives
