Stem cells from adipose tissue improve the time of wound healing in rats

Nine male Wistar rats were randomly distributed into three groups I) 7 days of healing; II) 14 days of healing; III) 21 days of healing. Four incisions were made on the dorsal surface of each rat and then treated with intralesional ACS, meloxicam, and no treatment and ACS+meloxicam. Macroscopic evaluation was measured by percentage of healing and histopathological by hematoxylin-eosin was performed.

RESULTS:

All groups have the wound reduced during the three weeks (p<0.001) and after 14 days of healing had greater reduction than others. Wounds treated with ASC had accelerated healing in relation to no treatment and only meloxicam (p<0.001), excepting the ASC+Meloxicam that was similar (p=0.13). There was no difference in histopathological analysis between lesions.

CONCLUSION:

Adipose stem cell have benefits in reducing time of healing of experimental model of wound in rats, observed 7 days of after application.

Key words:
Adipose Tissue; Wound Healing; Stem Cells; Rats

Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia https://actacirbras.com.br/ - São Paulo - SP - Brazil
E-mail: actacirbras@gmail.com

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[1] Correspondence: Edson Yuzur Yasojima Travessa Arciprestes Manoel Teodoro, 772/1102 66015040 Belém-PA Brasil Tel.: (91)99991-8882 yasojima@globo.com

Groups	Time of healing
Groups	7 days ^a,b	14 days ^a,c	21 days ^b,c
ASCs ^d,e	53.25	82.82	76.26
ASCs + Meloxicam ^f,g	56.54	88.12	78.51
Control ^d,f	41.02	75.39	62.33
Meloxicam ^e,g	35.07	75.01	58.56

Brasil

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Stem cells from adipose tissue improve the time of wound healing in rats1 1 Research performed at Universidade Federal do Pará (UFPA), Laboratory of In Vitro Fertilization, and Laboratory of Experimental Surgery, Universidade Estadual do Pará, Belem-PA, Brazil.

ABSTRACT

PURPOSE:

METHODS:

RESULTS:

CONCLUSION:

Stem cells from adipose tissue improve the time of wound healing in rats^¹ 1 Research performed at Universidade Federal do Pará (UFPA), Laboratory of In Vitro Fertilization, and Laboratory of Experimental Surgery, Universidade Estadual do Pará, Belem-PA, Brazil.