The importance of biomaterials in medicine embraces several surgical areas. To compare the tissue reaction concerning silicone implantation, one of the most utilized, with the implantation of expanded polytetrafluoroethyllene (E-PTFE), of recent use, we have proposed this study. Thirty rats (Rattus norvegicus albinus) males, have been distributed in three groups, with implants of discoids fragments of the materials, at the back of the each one. The groups differed as to the time period of euthanasya, 3, 7 and 30 days. Based on the experimental model utilized, from the histologic point of view there has been no important acute inflamatory reaction that could be corelated to the implanted materials. The vascular proliferation and the presence of fibrosis were prolonged in relation to normal repair. The irregularity of E-PTFE was probably related to the greater amount of blood vassels and late fibrosis found in this material when compared to the silicone implant.
Silicone; Politetrafluoroetilene; Wound healing; Rats
