PURPOSE: In order to determine the behavior of the hepatic function in spontaneously hipertensive Rats Which underiwent low pressure and high pressure pneumoperitoneum. METHODS: 60 rats were studied two groups of 30 rats, each formed by 15 Wistar EPM-1 and 15 SHR, were subjmitted to 4mmHg and 10mmHg pressure respectively, for 1 hour plus peritoneal pressure normalization time of 1 hour. Immediately after being weighed the rats were given an anesthetic (cetamine and xylazine) intramuscular. Blood samples for hepatic function evaluation were taken immediately after the insertion of a catheter in the left femural artery as well as after 1 hour insufflation and after the one-hour pressure normalization. The significance coeficient was 5 %. RESULTS: Animals submitted to 4mmHg pressure had inicial AST and ALT levels lower than after insuflation and after pressure normalization. DHL, BT and BD levels did not change for both strains. Animals submitte to 10mmHg pressure AST and DHL levels modification for normotensive rats but increased for hypertensive ones; BD did not change; ALT and BT changed for Wistar and SHR. CONCLUSION: Our study shows that pneumoperitoneum has changed the hepatic function of the animals and suggests that one-hour peritoneal pressure normalization seems to be too short to allow hepatic function normalization in both hyper and normotensive animals.
Pneumoperitoneum, artificial; Rats, inbred SHR; Liver
